Protein: VPS16
Vacuolar protein sorting-associated protein 16 homolog (hVPS16)

Gene: VPS16
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q9H269

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0005768 - endosome
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1383671

VP33A
Vacuolar protein sorting-associated protein 33A

11

4

Small-scale

0.982

High

1431583

VPS18
Vacuolar protein sorting-associated protein 18 homolog

6

13

Small-scale

0.740

High

888815

VPS41
Vacuolar protein sorting-associated protein 41 homolog

6

13

Small-scale

0.736

High

1431575

VPS11
Vacuolar protein sorting-associated protein 11 homolog

6

13

Small-scale

0.736

High

1356707

TGFA1
Transforming growth factor-beta receptor-associated protein 1

5

11

Small-scale

0.716

High

1325278

VPS8
Vacuolar protein sorting-associated protein 8 homolog

3

2

Small-scale

0.667

High

901559

RAB7A
Ras-related protein Rab-7a

2

2

Small-scale

0.595

High

1431585

UVRAG
UV radiation resistance-associated gene protein

2

0

Small-scale

0.559

High

640286

EPHA1
Ephrin type-A receptor 1

2

1

High-throughput

0.549

High

943129

STX17
Syntaxin-17

1

1

Small-scale

0.536

High

1051054

FAK1
Focal adhesion kinase 1

1

1

High-throughput

0.536

High

270683

ATP9A
Probable phospholipid-transporting ATPase IIA

1

0

High-throughput

0.513

High

839367

MTOR
Serine/threonine-protein kinase mTOR

1

0

High-throughput

0.513

High

957009

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.513

High

1177085

INF2
Inverted formin-2

1

0

High-throughput

0.513

High

1369653

PMM1
Phosphomannomutase 1

1

0

High-throughput

0.513

High

1420217

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1431580

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

1431594

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

Small-scale

0.513

High

1398892

RILP
Rab-interacting lysosomal protein

1

0

Small-scale

0.505

High

508608

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

1159634

STX1A
Syntaxin-1A

1

3

Small-scale

0.501

High

973585

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.489

High

1397650

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

1403422

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

1315129

EXOC8
Exocyst complex component 8

1

1

High-throughput

0.481

High

226197

STX6
Syntaxin-6

1

3

High-throughput

0.479

High

242895

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

560516

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

902061

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

933052

SNAA
Alpha-soluble NSF attachment protein

1

1

High-throughput

0.479

High

1031539

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1291580

HOOK3
Protein Hook homolog 3

1

2

Small-scale

0.479

High

1388857

HOOK2
Protein Hook homolog 2

1

2

Small-scale

0.479

High

1394866

VPS39
Vam6/Vps39-like protein

1

11

Small-scale

0.479

High

1431587

HOOK1
Protein Hook homolog 1

1

2

Small-scale

0.479

High

1431589

STX8
Syntaxin-8

1

4

High-throughput

0.479

High

218758

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

373124

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

412590

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

1431579

AKTIP
AKT-interacting protein

1

0

Small-scale

0.458

High

1347730

ZN417
Zinc finger protein 417

1

1

High-throughput

0.439

High

1431584

GBG13

1

1

High-throughput

0.439

High

1431574

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

Small-scale

0.438

High

280819

PR40A
Pre-mRNA-processing factor 40 homolog A

1

1

High-throughput

0.437

High

1193527

TTC31
Tetratricopeptide repeat protein 31

1

1

High-throughput

0.437

High

1431592

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.437

High

166412

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

437789

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

530367

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

564353

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

877719

SL9A3
Sodium/hydrogen exchanger 3

1

0

High-throughput

0.426

High

1227438

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1279083

RIC3
Protein RIC-3

1

0

High-throughput

0.426

High

1329191

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.426

High

1366227

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

1431591

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

109546

G5E9H3
Tetratricopeptide repeat domain 31

1

1

High-throughput

0.407

High

116523

H7C2N3
Pre-mRNA processing factor 40 homolog A

1

1

High-throughput

0.407

High

116740

I3L0E3
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.407

High

938183

PKNX1
Homeobox protein PKNOX1

3

0

High-throughput

0.347

High

1356623

CT55
Cancer/testis antigen 55

3

0

High-throughput

0.347

High

175529

TCPR2
Tectonin beta-propeller repeat-containing protein 2

2

0

High-throughput

0.328

High

1248583

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1396448

F167A
Protein FAM167A

2

0

High-throughput

0.328

High

1384957

CC127
Coiled-coil domain-containing protein 127

2

0

High-throughput

0.313

High

1431586

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.305

High

216815

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.279

Low

247165

TBCD4
TBC1 domain family member 4

1

0

High-throughput

0.279

Low

261556

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

296828

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

297687

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.279

Low

334903

IPO7
Importin-7

1

0

High-throughput

0.279

Low

335707

MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

1

0

High-throughput

0.279

Low

472350

CFAH
Complement factor H

1

0

High-throughput

0.279

Low

787340

ACV1B
Activin receptor type-1B

1

0

High-throughput

0.279

Low

884702

SYHM
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1012362

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.279

Low

1029550

SRSF2
Serine/arginine-rich splicing factor 2

1

0

High-throughput

0.279

Low

1109386

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.279

Low

1180354

ZN800
Zinc finger protein 800

1

0

High-throughput

0.279

Low

1192207

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

1207263

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1240543

RM54
Large ribosomal subunit protein mL54

1

0

High-throughput

0.279

Low

1257297

STXB4
Syntaxin-binding protein 4

1

0

High-throughput

0.279

Low

1325837

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1381281

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.279

Low

1382661

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.279

Low

1394981

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

1400582

CIB3
Calcium and integrin-binding family member 3

1

0

High-throughput

0.279

Low

1406984

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1415626

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.279

Low

1416810

C1QT6
Complement C1q tumor necrosis factor-related protein 6

1

0

High-throughput

0.279

Low

1417875

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.279

Low

1420841

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

1431577

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.279

Low

1431578

ESRP2
Epithelial splicing regulatory protein 2

1

0

High-throughput

0.279

Low

1431588

HSPB8
Heat shock protein beta-8

1

0

High-throughput

0.279

Low

1271334

MON1B
Vacuolar fusion protein MON1 homolog B

1

0

Small-scale

0.275

Low

1431593

FBX7
F-box only protein 7

1

0

High-throughput

0.261

Low

106636

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

260443

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

414598

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

573249

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.249

Low

589659

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696476

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769146

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1100369

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

1115421

CUL4B
Cullin-4B

1

0

High-throughput

0.249

Low

1255496

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1276774

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1380157

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.249

Low

1380655

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

1383403

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.249

Low

1385389

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.249

Low

1390535

CDCA5
Sororin

1

0

High-throughput

0.249

Low

1399026

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

1431576

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1431581

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1431590

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

0

High-throughput

0.249

Low

143759

WN10B
Protein Wnt-10b

1

0

High-throughput

0.232

Low

171577

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.232

Low

835386

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.232

Low

896452

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.232

Low

1153436

CD226
CD226 antigen

1

0

High-throughput

0.232

Low

1167113

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low

1219545

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low

1239294

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1289151

OSTA
Organic solute transporter subunit alpha

1

0

High-throughput

0.232

Low

1332135

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low

1334410

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.232

Low

1359316

SSMM1
Serine-rich single-pass membrane protein 1

1

0

High-throughput

0.232

Low

1415666

TR61B
tRNA

1

0

High-throughput

0.232

Low

1431240

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.232

Low

1431582

CEP72
Centrosomal protein of 72 kDa

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025