Protein: H1
Histone H1

Gene: H1, HHO1
Organism: Saccharomyces cerevisiae S288C
Interactions: 167
UniProt ID: P53551

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0003676 - nucleic acid binding
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

921183

H2AZ
Histone H2A.Z

4

1

Small-scale

0.885

High

921151

H3
Histone H3

3

0

Small-scale

0.801

High

364669

CDK1
Cyclin-dependent kinase 1

8

0

Small-scale

0.716

High

419822

H2A2
Histone H2A.2

2

0

High-throughput

0.699

High

547813

NHP6A
Non-histone chromosomal protein 6A

2

1

Small-scale

0.613

High

814352

NOC2
Nucleolar complex protein 2

2

0

High-throughput

0.587

High

921149

MOT3
Transcriptional activator/repressor MOT3

2

0

High-throughput

0.583

High

823011

ATAD2
ATPase histone chaperone YTA7

2

1

High-throughput

0.571

High

646483

RAD53
Serine/threonine-protein kinase RAD53

2

0

Small-scale

0.569

High

826707

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

382247

H4
Histone H4

2

0

High-throughput

0.547

High

381191

H2B1
Histone H2B.1

1

0

High-throughput

0.546

High

149879

RS9A
Small ribosomal subunit protein uS4A

2

1

High-throughput

0.533

High

433762

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.533

High

504334

RL31A
Large ribosomal subunit protein eL31A

2

1

High-throughput

0.533

High

921152

ARP4
Actin-related protein 4

1

0

Small-scale

0.529

High

656987

BUR1
Serine/threonine-protein kinase BUR1

1

1

High-throughput

0.515

High

644667

MAG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.513

High

921154

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

921163

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.513

High

645958

DBF2
Cell cycle protein kinase DBF2

1

1

Small-scale

0.501

High

740601

IME2
Meiosis induction protein kinase IME2/SME1

1

1

Small-scale

0.501

High

653797

APN1
Apurinic-apyrimidinic endonuclease 1

1

0

High-throughput

0.493

High

805519

ORC6
Origin recognition complex subunit 6

1

0

High-throughput

0.493

High

807682

HRB1
Serine/arginine

1

0

High-throughput

0.493

High

547880

NHP6B
Non-histone chromosomal protein 6B

1

1

Small-scale

0.481

High

667106

CG22
G2/mitotic-specific cyclin-2

1

0

Small-scale

0.480

High

805831

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.480

High

921171

RT109
Histone acetyltransferase RTT109

1

0

Small-scale

0.480

High

531826

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.479

High

885036

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.479

High

917300

INO80
Chromatin-remodeling ATPase INO80

1

1

Small-scale

0.479

High

921148

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.479

High

408430

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.460

High

921179

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.460

High

448322

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

594490

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

617809

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.458

High

641438

RCC1
Guanine nucleotide exchange factor SRM1

1

0

Small-scale

0.458

High

647176

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

672922

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

679919

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

684798

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

735084

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

739427

ZUO1
Zuotin

1

0

High-throughput

0.458

High

745825

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

763953

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

792167

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

804337

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.458

High

806482

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

808872

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

809378

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

850374

IOC3
ISWI one complex protein 3

1

0

Small-scale

0.458

High

921147

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

921159

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

921164

POB3
FACT complex subunit POB3

1

0

High-throughput

0.458

High

921168

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

921173

SGO1
Shugoshin

1

0

High-throughput

0.458

High

921177

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.458

High

921184

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.458

High

921185

RL11B
Large ribosomal subunit protein uL5B

1

0

High-throughput

0.458

High

734317

DBF20
Serine/threonine-protein kinase DBF20

1

1

Small-scale

0.457

High

444862

SIR3
Regulatory protein SIR3

1

1

High-throughput

0.445

High

488978

SWI6
Regulatory protein SWI6

1

1

High-throughput

0.445

High

545741

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

671542

SWI4
Regulatory protein SWI4

1

1

High-throughput

0.445

High

754172

MSN2
Zinc finger protein MSN2

1

1

High-throughput

0.445

High

754230

MSN4
Zinc finger protein MSN4

1

1

High-throughput

0.445

High

819378

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

921156

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

2

High-throughput

0.445

High

921166

SWR1
Helicase SWR1

1

1

High-throughput

0.445

High

921167

FKBP4
FK506-binding protein 4

1

0

High-throughput

0.438

High

383169

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.437

High

427593

RLA1
Large ribosomal subunit protein P1A

1

1

High-throughput

0.437

High

427731

RLA2
Large ribosomal subunit protein P2A

1

1

High-throughput

0.437

High

432651

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.437

High

432887

RL9A
Large ribosomal subunit protein uL6A

1

1

High-throughput

0.437

High

433054

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.437

High

433254

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.437

High

434623

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.437

High

435610

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.437

High

504542

RL31B
Large ribosomal subunit protein eL31B

1

1

High-throughput

0.437

High

528850

RLA3
Large ribosomal subunit protein P1B

1

1

High-throughput

0.437

High

601093

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.437

High

689089

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.437

High

689255

RL16B
Large ribosomal subunit protein uL13B

1

1

High-throughput

0.437

High

712631

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.437

High

747495

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

781233

RL14A
Large ribosomal subunit protein eL14A

1

1

High-throughput

0.437

High

803417

RL14B
Large ribosomal subunit protein eL14B

1

1

High-throughput

0.437

High

820928

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.437

High

825886

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.437

High

858036

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.437

High

863857

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.437

High

902657

RL9B
Large ribosomal subunit protein uL6B

1

1

High-throughput

0.437

High

918309

RL26B
Large ribosomal subunit protein uL24B

1

1

High-throughput

0.437

High

921150

RL22B
Large ribosomal subunit protein eL22B

1

1

High-throughput

0.437

High

921153

RL34A
Large ribosomal subunit protein eL34A

1

1

High-throughput

0.437

High

921157

RL6A
Large ribosomal subunit protein eL6A

1

1

High-throughput

0.437

High

921169

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

1

Small-scale

0.437

High

921178

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.437

High

921180

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

921182

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.437

High

448201

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.426

High

524700

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

645629

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

649994

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

694602

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

736690

ASF1
Histone chaperone ASF1

1

0

High-throughput

0.426

High

739706

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.426

High

746336

RGT1
Glucose transport transcription regulator RGT1

1

0

High-throughput

0.426

High

781149

SWD2
COMPASS component SWD2

1

0

High-throughput

0.426

High

781775

SET3
SET domain-containing protein 3

1

0

High-throughput

0.426

High

820428

RT106
Histone chaperone RTT106

1

0

High-throughput

0.426

High

921160

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.426

High

921161

HOS3
Histone deacetylase HOS3

1

0

High-throughput

0.426

High

921162

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

921165

RCO1
Transcriptional regulatory protein RCO1

1

0

High-throughput

0.426

High

921170

BRE1
E3 ubiquitin-protein ligase BRE1

1

0

High-throughput

0.426

High

921172

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

921174

ESA1
Histone acetyltransferase ESA1

1

0

High-throughput

0.426

High

921181

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.426

High

410253

RL25
Large ribosomal subunit protein uL23

2

0

High-throughput

0.305

High

700265

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.282

High

921176

ENV7
Serine/threonine-protein kinase ENV7

1

0

Small-scale

0.261

Low

149219

FOB1
DNA replication fork-blocking protein FOB1

1

0

Small-scale

0.249

Low

154202

RL36B
Large ribosomal subunit protein eL36B

1

0

High-throughput

0.249

Low

383816

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

427384

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.249

Low

434057

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.249

Low

434415

RL15A
Large ribosomal subunit protein eL15A

1

0

High-throughput

0.249

Low

436081

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

442033

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

455181

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

482065

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.249

Low

503160

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

503941

RL27B
Large ribosomal subunit protein eL27B

1

0

High-throughput

0.249

Low

511245

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

511459

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.249

Low

512564

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

513132

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514038

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

514332

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.249

Low

514753

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

515143

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

515293

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

570091

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.249

Low

663702

RL24B
Large ribosomal subunit protein eL24B

1

0

High-throughput

0.249

Low

674747

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

677504

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

682351

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

689576

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

778456

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

795127

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

802297

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

812092

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.249

Low

812523

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

835847

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

858280

ARC1
tRNA-aminoacylation cofactor ARC1

1

0

High-throughput

0.249

Low

874441

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

879829

RL37A
Large ribosomal subunit protein eL37A

1

0

High-throughput

0.249

Low

921145

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.249

Low

921155

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

921158

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

921175

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

858389

STU2
Protein STU2

1

0

High-throughput

0.232

Low

921146

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025