Protein: SEA4
SEH-associated protein 4

Gene: SEA4
Organism: Saccharomyces cerevisiae S288C
Interactions: 90
UniProt ID: P38164

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005774 - vacuolar membrane
GO:0015031 - protein transport
GO:0035859 - Seh1-associated complex
GO:1903432 - regulation of TORC1 signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

794715

SEH1
Nucleoporin SEH1

4

5

Small-scale

0.878

High

794724

WDR59
Maintenance of telomere capping protein 5

3

6

Small-scale

0.834

High

794733

RTC1
Restriction of telomere capping protein 1

3

6

Small-scale

0.834

High

794718

2ABA
Protein phosphatase PP2A regulatory subunit B

2

0

High-throughput

0.770

High

794729

SEC13
Protein transport protein SEC13

2

5

Small-scale

0.767

High

579264

HSC82
ATP-dependent molecular chaperone HSC82

4

1

High-throughput

0.673

High

794706

NPR2
Nitrogen permease regulator 2

3

3

Small-scale

0.646

High

794713

IML1
Vacuolar membrane-associated protein IML1

3

3

Small-scale

0.646

High

794702

NPR3
Nitrogen permease regulator 3

3

0

Small-scale

0.619

High

794700

SEA4
SEH-associated protein 4

1

1

High-throughput

0.575

High

794709

LST8
Target of rapamycin complex subunit LST8

1

1

High-throughput

0.575

High

794705

MET30
F-box protein MET30

1

0

High-throughput

0.560

High

560685

KIN2
Serine/threonine-protein kinase KIN2

1

0

High-throughput

0.513

High

642370

MCK1
Protein kinase MCK1

1

0

High-throughput

0.513

High

709362

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

794707

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

0

High-throughput

0.513

High

794711

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.481

High

392612

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

460332

SYV
Valine--tRNA ligase, mitochondrial

1

0

High-throughput

0.460

High

149720

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

435038

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

435920

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

438674

SC160
Protein SCP160

1

0

High-throughput

0.458

High

674577

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

726965

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

747813

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

778285

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

794701

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

794714

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

794716

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

794720

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

794725

FIN1
Filament protein FIN1

1

0

Small-scale

0.458

High

794726

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

794732

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

794735

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

523715

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526495

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

592191

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

598850

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

1

High-throughput

0.445

High

599001

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.445

High

794736

CDC53
Cell division control protein 53

1

1

High-throughput

0.445

High

420918

PMA1
Plasma membrane ATPase 1

1

0

High-throughput

0.426

High

450572

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

453554

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

544599

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

572563

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.426

High

639007

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.426

High

647758

RFA1
Replication factor A protein 1

1

0

High-throughput

0.426

High

737401

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

0

High-throughput

0.426

High

762810

TOR1
Serine/threonine-protein kinase TOR1

1

0

High-throughput

0.426

High

794703

KOG1
Target of rapamycin complex 1 subunit KOG1

1

0

High-throughput

0.426

High

452888

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.407

High

603455

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.407

High

626705

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.407

High

794737

NOP56
Nucleolar protein 56

1

1

High-throughput

0.407

High

794738

NOP58
Nucleolar protein 58

1

1

High-throughput

0.407

High

794708

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

794721

LGE1
Transcriptional regulatory protein LGE1

2

0

High-throughput

0.298

High

744104

BRR2
Pre-mRNA-splicing helicase BRR2

1

0

High-throughput

0.279

Low

794719

AP1M1
AP-1 complex subunit mu-1-I

1

0

High-throughput

0.279

Low

794722

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.279

Low

794731

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.279

Low

794734

DIA2
Protein DIA2

1

0

High-throughput

0.279

Low

433597

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

441866

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

689010

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.249

Low

689409

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

706888

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

747319

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

748359

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

779210

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

794712

SET4
SET domain-containing protein 4

1

0

Small-scale

0.249

Low

794723

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

794727

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

794728

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low

368647

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.232

Low

448444

RAD52
DNA repair and recombination protein RAD52

1

0

High-throughput

0.232

Low

534255

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

High-throughput

0.232

Low

584226

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

0

High-throughput

0.232

Low

585261

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.232

Low

585547

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.232

Low

618578

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.232

Low

644759

CLH
Clathrin heavy chain

1

0

High-throughput

0.232

Low

692560

NSR1
Nuclear localization sequence-binding protein

1

0

High-throughput

0.232

Low

744746

MG101
Mitochondrial genome maintenance protein MGM101

1

0

High-throughput

0.232

Low

794704

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

794710

COPB
Coatomer subunit beta

1

0

High-throughput

0.232

Low

794717

ACT
Actin

1

0

High-throughput

0.232

Low

794730

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025