Protein: PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2)

Gene: PLOD2
Organism: Homo sapiens
Interactions: 106
UniProt ID: O00469

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0005506 - iron ion binding
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

137057

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

10

High-throughput

0.811

High

137015

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

2

10

High-throughput

0.776

High

137008

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

10

Small-scale

0.647

High

137107

COLQ
Acetylcholinesterase collagenic tail peptide

2

20

High-throughput

0.628

High

137099

FBX6
F-box only protein 6

3

6

High-throughput

0.599

High

137108

RUVB2
RuvB-like 2

2

0

High-throughput

0.595

High

137051

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

2

6

High-throughput

0.574

High

137009

FCN1
Ficolin-1

1

2

High-throughput

0.536

High

137020

C1QA
Complement C1q subcomponent subunit A

1

20

High-throughput

0.536

High

137021

C1QB
Complement C1q subcomponent subunit B

1

20

High-throughput

0.536

High

137036

CO8A2
Collagen alpha-2(VIII) chain

1

20

High-throughput

0.536

High

137038

CALX
Calnexin

1

8

High-throughput

0.536

High

137058

COAA1

1

20

High-throughput

0.536

High

137065

ADIPO
Adiponectin

1

20

High-throughput

0.536

High

137075

CONA1

1

20

High-throughput

0.536

High

137077

GT252
Procollagen galactosyltransferase 2

1

10

High-throughput

0.536

High

137090

COLA1

1

20

High-throughput

0.536

High

137092

COL11
Collectin-11

1

20

High-throughput

0.536

High

137093

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

20

High-throughput

0.536

High

137094

C1QT3
Complement C1q tumor necrosis factor-related protein 3

1

20

High-throughput

0.536

High

137100

CBLN4
Cerebellin-4

1

20

High-throughput

0.536

High

137111

COL10
Collectin-10

1

20

High-throughput

0.536

High

137035

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.515

High

137043

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

0

High-throughput

0.513

High

137109

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.513

High

137110

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

73747

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

20

High-throughput

0.489

High

137042

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

6

High-throughput

0.489

High

137050

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.489

High

137063

EPHA7
Ephrin type-A receptor 7

1

9

High-throughput

0.489

High

137012

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

137013

CALU
Calumenin

1

3

High-throughput

0.479

High

137014

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

137017

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

137022

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

137024

CFAH
Complement factor H

1

1

Small-scale

0.479

High

137025

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

High-throughput

0.479

High

137026

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

137030

PDIA4
Protein disulfide-isomerase A4

1

7

High-throughput

0.479

High

137033

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.479

High

137045

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.479

High

137053

SC61B
Protein transport protein Sec61 subunit beta

1

3

High-throughput

0.479

High

137054

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

137055

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

137056

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

137059

DNJC3
DnaJ homolog subfamily C member 3

1

14

High-throughput

0.479

High

137060

OS9
Protein OS-9

1

3

Small-scale

0.479

High

137061

CUL3
Cullin-3

1

7

High-throughput

0.479

High

137062

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.479

High

137066

TECT1
Tectonic-1

1

5

High-throughput

0.479

High

137072

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

137079

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.479

High

137080

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

137081

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

137085

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

137088

CALR3
Calreticulin-3

1

8

High-throughput

0.479

High

137097

RHOJ
Rho-related GTP-binding protein RhoJ

1

5

High-throughput

0.479

High

137102

VAPA
Vesicle-associated membrane protein-associated protein A

1

3

High-throughput

0.479

High

137103

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.479

High

137011

INSI1
Insulin-induced gene 1 protein

1

0

High-throughput

0.458

High

137023

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.458

High

137027

UBL4A
Ubiquitin-like protein 4A

1

0

High-throughput

0.458

High

137039

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

Small-scale

0.458

High

137076

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

137082

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

137084

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

137019

CO1A1
Collagen alpha-1(I) chain

1

20

Small-scale

0.445

High

137028

CO6A2

1

20

High-throughput

0.445

High

137029

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

137083

S39A7
Zinc transporter SLC39A7

1

2

High-throughput

0.445

High

137010

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.437

High

137016

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.437

High

137031

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

137032

EFNA1
Ephrin-A1

1

6

High-throughput

0.437

High

137037

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

137044

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

137047

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.437

High

137048

EFNA4
Ephrin-A4

1

6

High-throughput

0.437

High

137049

TERF1
Telomeric repeat-binding factor 1

1

3

High-throughput

0.437

High

137052

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

2

High-throughput

0.437

High

137064

TERF2
Telomeric repeat-binding factor 2

1

3

High-throughput

0.437

High

137067

EPHAA
Ephrin type-A receptor 10

1

9

High-throughput

0.437

High

137073

SYNE3
Nesprin-3

1

3

High-throughput

0.437

High

137074

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

137098

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

137101

T106B
Transmembrane protein 106B

1

4

High-throughput

0.437

High

137104

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

137018

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.407

High

137034

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

137070

S39A4
Zinc transporter ZIP4

1

2

High-throughput

0.407

High

137071

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

2

High-throughput

0.407

High

137096

ATG5
Autophagy protein 5

1

2

High-throughput

0.407

High

137040

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.279

Low

137069

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.279

Low

137106

ITBP2
Integrin beta-1-binding protein 2

1

0

High-throughput

0.279

Low

137046

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

137078

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

137089

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

137091

ZIM3
Zinc finger imprinted 3

1

0

High-throughput

0.249

Low

137095

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

137105

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

137041

CTR1
High affinity cationic amino acid transporter 1

1

0

High-throughput

0.232

Low

137068

S35F1
Solute carrier family 35 member F1

1

0

High-throughput

0.232

Low

137086

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.232

Low

137087

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025