Protein: UBP22
Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)

Gene: UBP22, USP22
Organism: Homo sapiens
Interactions: 153
UniProt ID: Q9UPT9

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000124 - SAGA complex
GO:0003713 - transcription coactivator activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1062121

AT7L3
Ataxin-7-like protein 3

13

4

Small-scale

0.981

High

1342573

ENY2
Transcription and mRNA export factor ENY2

5

3

Small-scale

0.919

High

267805

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

3

11

High-throughput

0.855

High

64224

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

2

13

High-throughput

0.776

High

1357755

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

2

12

Small-scale

0.754

High

1271469

KAT2A
Histone acetyltransferase KAT2A

11

15

Small-scale

0.754

High

1289478

SIR1
NAD-dependent protein deacetylase sirtuin-1

11

2

Small-scale

0.753

High

174002

ATX7
Ataxin-7

7

9

Small-scale

0.748

High

1243320

SP20H
Transcription factor SPT20 homolog

7

3

Small-scale

0.745

High

1290315

SGF29
SAGA-associated factor 29

6

3

Small-scale

0.732

High

1357757

TRRAP
Transformation/transcription domain-associated protein

6

8

Small-scale

0.729

High

1349389

PD1L1
Programmed cell death 1 ligand 1

5

3

Small-scale

0.721

High

348252

MYC
Myc proto-oncogene protein

5

8

Small-scale

0.713

High

266511

SUPT3
Transcription initiation protein SPT3 homolog

5

4

Small-scale

0.712

High

267718

TADA3
Transcriptional adapter 3

5

3

Small-scale

0.712

High

1285677

TADA1
Transcriptional adapter 1

4

3

High-throughput

0.697

High

599832

5NTD
5'-nucleotidase

4

3

Small-scale

0.694

High

1270219

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

10

High-throughput

0.691

High

1198587

TAD2B
Transcriptional adapter 2-beta

4

6

High-throughput

0.691

High

1021646

TAF10
Transcription initiation factor TFIID subunit 10

4

1

Small-scale

0.676

High

826094

FAS
Fatty acid synthase

3

1

Small-scale

0.667

High

777086

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

13

High-throughput

0.665

High

297945

ST65G
STAGA complex 65 subunit gamma

3

2

High-throughput

0.662

High

905265

1433G
14-3-3 protein gamma

3

20

High-throughput

0.662

High

1083711

TAF9
Transcription initiation factor TFIID subunit 9

3

5

High-throughput

0.662

High

1357758

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

3

3

High-throughput

0.662

High

1335544

TAF9B
Transcription initiation factor TFIID subunit 9B

3

5

Small-scale

0.656

High

476579

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

1240393

MINY2
Ubiquitin carboxyl-terminal hydrolase MINDY-2

3

0

High-throughput

0.638

High

232595

KDM1A
Lysine-specific histone demethylase 1A

3

0

Small-scale

0.636

High

330604

ZBED1
E3 SUMO-protein ligase ZBED1

2

1

High-throughput

0.628

High

1168542

RN19B
E3 ubiquitin-protein ligase RNF19B

2

10

High-throughput

0.628

High

1285299

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

1

High-throughput

0.628

High

1017468

CDC20
Cell division cycle protein 20 homolog

1

8

Small-scale

0.618

High

1174034

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

15

High-throughput

0.618

High

1082089

TAF12
Transcription initiation factor TFIID subunit 12

2

2

High-throughput

0.611

High

1101558

KIF7
Kinesin-like protein KIF7

2

3

High-throughput

0.611

High

1127211

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

4

High-throughput

0.606

High

1217291

UN5CL
UNC5C-like protein

2

0

High-throughput

0.602

High

1292919

A7L3B
Ataxin-7-like protein 3B

2

3

Small-scale

0.601

High

245100

BRD4
Bromodomain-containing protein 4

2

14

Small-scale

0.584

High

1271514

KAT2B
Histone acetyltransferase KAT2B

2

14

High-throughput

0.584

High

314175

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

722989

PGH2
Prostaglandin G/H synthase 2

1

1

Small-scale

0.578

High

259513

LRRN2
Leucine-rich repeat neuronal protein 2

2

3

High-throughput

0.574

High

1083504

C3AR
C3a anaphylatoxin chemotactic receptor

2

1

High-throughput

0.574

High

1165591

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

2

1

High-throughput

0.574

High

1356909

AT7L1
Ataxin-7-like protein 1

2

10

High-throughput

0.574

High

538628

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.561

High

718324

BMI1
Polycomb complex protein BMI-1

1

15

Small-scale

0.561

High

740621

PPARG
Peroxisome proliferator-activated receptor gamma

1

8

Small-scale

0.561

High

741105

ZEB1
Zinc finger E-box-binding homeobox 1

1

2

Small-scale

0.561

High

1205496

PALB2
Partner and localizer of BRCA2

1

1

Small-scale

0.561

High

1283868

FUBP1
Far upstream element-binding protein 1

1

2

Small-scale

0.554

High

1134050

AT7L2
Ataxin-7-like protein 2

2

9

High-throughput

0.549

High

181363

ARPC5
Actin-related protein 2/3 complex subunit 5

1

1

High-throughput

0.536

High

454781

TACD2
Tumor-associated calcium signal transducer 2

1

1

High-throughput

0.536

High

568832

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

3

High-throughput

0.536

High

647384

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

896851

ARP3
Actin-related protein 3

1

1

High-throughput

0.536

High

897000

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

970751

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

1

High-throughput

0.536

High

982625

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1073187

SF3B3
Splicing factor 3B subunit 3

1

2

High-throughput

0.536

High

1308643

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

1

High-throughput

0.536

High

865124

RCAN1
Calcipressin-1

1

0

Small-scale

0.529

High

986872

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.518

High

1192940

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.518

High

1035295

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

Small-scale

0.515

High

1116995

PPCEL
Prolyl endopeptidase-like

1

1

High-throughput

0.515

High

168989

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.513

High

362313

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

1053304

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

1222022

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

1326699

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

0

High-throughput

0.513

High

1334336

RM44
Large ribosomal subunit protein mL44

1

1

High-throughput

0.508

High

391971

H2A1B
Histone H2A type 1-B/E

1

14

Small-scale

0.501

High

707794

H2B1B
Histone H2B type 1-B

1

18

Small-scale

0.501

High

1087135

H2A2C
Histone H2A type 2-C

1

14

Small-scale

0.501

High

1087489

H2B2E
Histone H2B type 2-E

1

18

Small-scale

0.501

High

61501

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.493

High

271714

DEDD
Death effector domain-containing protein

1

0

High-throughput

0.493

High

1183050

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.493

High

1334118

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.493

High

180762

PA2GX
Group 10 secretory phospholipase A2

1

2

High-throughput

0.489

High

1134324

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

3

High-throughput

0.489

High

1301663

RB40C
Ras-related protein Rab-40C

1

1

High-throughput

0.489

High

1330444

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.489

High

169314

MDM4
Protein Mdm4

1

5

Small-scale

0.479

High

177733

BIRC5
Baculoviral IAP repeat-containing protein 5

1

2

Small-scale

0.479

High

214693

MYO1B
Unconventional myosin-Ib

1

2

Small-scale

0.479

High

265733

E2F6
Transcription factor E2F6

1

3

Small-scale

0.479

High

266450

TAD2A
Transcriptional adapter 2-alpha

1

6

Small-scale

0.479

High

272763

OFD1
Centriole and centriolar satellite protein OFD1

1

4

High-throughput

0.479

High

415107

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.479

High

487848

ANDR
Androgen receptor

1

11

Small-scale

0.479

High

516747

PABP1
Polyadenylate-binding protein 1

1

2

Small-scale

0.479

High

523210

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.479

High

554068

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

572578

SPI1
Transcription factor PU.1

1

1

Small-scale

0.479

High

648934

DPP4
Dipeptidyl peptidase 4

1

1

Small-scale

0.479

High

652619

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

776858

STAT3
Signal transducer and activator of transcription 3

1

6

Small-scale

0.479

High

786450

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

6

Small-scale

0.479

High

809028

YAP1
Transcriptional coactivator YAP1

1

7

Small-scale

0.479

High

853127

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

4

Small-scale

0.479

High

944482

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

Small-scale

0.479

High

967097

XPC
DNA repair protein complementing XP-C cells

1

1

Small-scale

0.479

High

1042855

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1080483

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

Small-scale

0.479

High

1085724

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.479

High

1140858

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.479

High

1172289

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1190128

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.479

High

1203593

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.479

High

1284593

E2F7
Transcription factor E2F7

1

3

Small-scale

0.479

High

1305003

KLF6
Krueppel-like factor 6

1

4

High-throughput

0.479

High

1356564

IKZF2
Zinc finger protein Helios

1

1

Small-scale

0.479

High

1239688

KLH23
Kelch-like protein 23

1

2

High-throughput

0.470

High

173625

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

431074

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

Small-scale

0.458

High

551869

DESP
Desmoplakin

1

0

Small-scale

0.458

High

783137

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.458

High

1230568

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.458

High

1356120

CDC23
Cell division cycle protein 23 homolog

1

0

Small-scale

0.458

High

573530

TCPA
T-complex protein 1 subunit alpha

1

4

Small-scale

0.437

High

778334

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

2

Small-scale

0.437

High

846546

BLK
Tyrosine-protein kinase Blk

1

3

High-throughput

0.437

High

831807

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

1344993

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

7

0

High-throughput

0.391

High

310363

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.347

High

661134

CD1B
T-cell surface glycoprotein CD1b

3

0

High-throughput

0.347

High

1190963

RIC3
Protein RIC-3

3

0

High-throughput

0.347

High

170576

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

2

0

High-throughput

0.328

High

702323

CD70
CD70 antigen

2

0

High-throughput

0.328

High

1071858

TMED2
Transmembrane emp24 domain-containing protein 2

2

0

High-throughput

0.328

High

1333296

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

420728

HEXA
Beta-hexosaminidase subunit alpha

1

0

High-throughput

0.282

High

1261669

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.282

High

157819

T4S5
Transmembrane 4 L6 family member 5

1

0

High-throughput

0.279

Low

196897

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.279

Low

454108

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.279

Low

813847

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

1032360

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

1059519

FXYD3
FXYD domain-containing ion transport regulator 3

1

0

High-throughput

0.279

Low

1157928

FXL22
F-box and leucine-rich protein 22

1

0

High-throughput

0.279

Low

1165310

LCTL
Lactase-like protein

1

0

High-throughput

0.279

Low

1261351

TM171
Transmembrane protein 171

1

0

High-throughput

0.279

Low

1265972

CLC2B
C-type lectin domain family 2 member B

1

0

High-throughput

0.279

Low

1328365

F234A
Protein FAM234A

1

0

High-throughput

0.279

Low

1356218

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

1357756

OFUT2
GDP-fucose protein O-fucosyltransferase 2

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024