Protein: TET2
Methylcytosine dioxygenase TET2 (EC 1.14.11.80)

Gene: TET2
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q6N021

Gene Ontology (top 5):
GO:0002521 - leukocyte differentiation
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

174965

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

5

5

Small-scale

0.727

High

909681

1433E
14-3-3 protein epsilon

3

1

Small-scale

0.656

High

927169

1433Z
14-3-3 protein zeta/delta

3

10

Small-scale

0.656

High

1069708

NONO
Non-POU domain-containing octamer-binding protein

2

5

High-throughput

0.628

High

1154488

EGLN3
Prolyl hydroxylase EGLN3

2

3

Small-scale

0.611

High

904716

1433G
14-3-3 protein gamma

3

10

Small-scale

0.593

High

982143

1433F
14-3-3 protein eta

3

10

Small-scale

0.593

High

381009

SEMG1
Semenogelin-1

2

0

High-throughput

0.585

High

585917

WT1
Wilms tumor protein

1

4

Small-scale

0.578

High

647002

1433T
14-3-3 protein theta

3

10

Small-scale

0.578

High

1154494

DCAF1
DDB1- and CUL4-associated factor 1

1

4

Small-scale

0.561

High

210484

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

1

High-throughput

0.552

High

1076165

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

High-throughput

0.552

High

1082498

HLF
Hepatic leukemia factor

1

2

High-throughput

0.552

High

1154472

RAI1
Retinoic acid-induced protein 1

1

1

High-throughput

0.552

High

1154478

ZCH14
Zinc finger CCHC domain-containing protein 14

1

1

High-throughput

0.552

High

1154473

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.549

High

1154477

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

159437

TFEC
Transcription factor EC

1

0

High-throughput

0.529

High

327672

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.529

High

567856

HXB9
Homeobox protein Hox-B9

1

0

High-throughput

0.529

High

786615

STA5A
Signal transducer and activator of transcription 5A

1

0

High-throughput

0.529

High

851256

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.529

High

878131

PKNX1
Homeobox protein PKNOX1

1

0

High-throughput

0.529

High

943068

PHC1
Polyhomeotic-like protein 1

1

0

High-throughput

0.529

High

1049232

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.529

High

1078720

SMAD1
Mothers against decapentaplegic homolog 1

1

0

High-throughput

0.529

High

1079873

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

0

High-throughput

0.529

High

161213

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.518

High

668760

PML
Protein PML

1

1

Small-scale

0.515

High

683446

1433B
14-3-3 protein beta/alpha

1

10

High-throughput

0.489

High

1154487

N62CL
Nucleoporin-62 C-terminal-like protein

1

1

High-throughput

0.489

High

328581

MBD3
Methyl-CpG-binding domain protein 3

1

2

Small-scale

0.479

High

364565

TRFE
Serotransferrin

1

1

Small-scale

0.479

High

364688

TRFL
Lactotransferrin

1

1

Small-scale

0.479

High

382032

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.479

High

399180

IL6
Interleukin-6

1

1

Small-scale

0.479

High

438267

HS90B
Heat shock protein HSP 90-beta

1

2

Small-scale

0.479

High

504251

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.479

High

505236

EGR2
E3 SUMO-protein ligase EGR2

1

3

High-throughput

0.479

High

564093

HSP76
Heat shock 70 kDa protein 6

1

2

Small-scale

0.479

High

682852

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

Small-scale

0.479

High

684120

1433S
14-3-3 protein sigma

1

10

High-throughput

0.479

High

713995

HS71L
Heat shock 70 kDa protein 1-like

1

2

Small-scale

0.479

High

724877

MYH9
Myosin-9

1

2

Small-scale

0.479

High

725181

MYH10
Myosin-10

1

2

Small-scale

0.479

High

727539

HNF1B
Hepatocyte nuclear factor 1-beta

1

1

High-throughput

0.479

High

751685

GRP75
Stress-70 protein, mitochondrial

1

3

Small-scale

0.479

High

772019

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

818157

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

831423

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.479

High

848235

HCFC1
Host cell factor 1

1

2

Small-scale

0.479

High

891836

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

918444

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

Small-scale

0.479

High

980783

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1041362

CUL2
Cullin-2

1

3

Small-scale

0.479

High

1046700

KLF5
Krueppel-like factor 5

1

1

High-throughput

0.479

High

1082232

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.479

High

1154470

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1154483

SOX7
Transcription factor SOX-7

1

1

High-throughput

0.479

High

1154486

EGLN1
Egl nine homolog 1

1

3

Small-scale

0.479

High

1154491

BCLF1
Bcl-2-associated transcription factor 1

1

1

High-throughput

0.479

High

1154495

DNM3A
DNA

1

1

Small-scale

0.479

High

134085

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

Small-scale

0.458

High

197734

CRX
Cone-rod homeobox protein

1

0

High-throughput

0.458

High

211884

TLX3
T-cell leukemia homeobox protein 3

1

0

High-throughput

0.458

High

215142

LANC1
Glutathione S-transferase LANCL1

1

0

Small-scale

0.458

High

318645

EYA4
Eyes absent homolog 4

1

0

High-throughput

0.458

High

325776

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

334214

LDHA
L-lactate dehydrogenase A chain

1

0

Small-scale

0.458

High

347059

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

363822

ALBU
Albumin

1

0

Small-scale

0.458

High

386928

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

417318

ENOA
Alpha-enolase

1

0

Small-scale

0.458

High

427586

ANXA2
Annexin A2

1

0

Small-scale

0.458

High

428258

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

443202

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.458

High

451471

CLCA
Clathrin light chain A

1

0

Small-scale

0.458

High

487524

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

507448

ERG
Transcriptional regulator ERG

1

0

High-throughput

0.458

High

516558

PABP1
Polyadenylate-binding protein 1

1

0

Small-scale

0.458

High

518385

ADT3
ADP/ATP translocase 3

1

0

Small-scale

0.458

High

551538

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

584989

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.458

High

629141

ZA2G
Zinc-alpha-2-glycoprotein

1

0

Small-scale

0.458

High

867215

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

Small-scale

0.458

High

903305

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

908700

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

910863

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

932750

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.458

High

988772

PAX8
Paired box protein Pax-8

1

0

High-throughput

0.458

High

989322

PRDX1
Peroxiredoxin-1

1

0

Small-scale

0.458

High

1072237

ELOC
Elongin-C

1

0

Small-scale

0.458

High

1072359

ELOB
Elongin-B

1

0

Small-scale

0.458

High

1085149

TBR1
T-box brain protein 1

1

0

High-throughput

0.458

High

1119431

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

1154039

NIPBL
Nipped-B-like protein

1

0

High-throughput

0.458

High

1154475

SP7
Transcription factor Sp7

1

0

High-throughput

0.458

High

1154479

RBP56
TATA-binding protein-associated factor 2N

1

0

Small-scale

0.458

High

1154480

RNF31
E3 ubiquitin-protein ligase RNF31

1

0

High-throughput

0.458

High

1154481

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.458

High

1154482

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1154484

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

1154490

GCM1
Chorion-specific transcription factor GCMa

1

0

High-throughput

0.458

High

1154493

COE1
Transcription factor COE1

1

0

Small-scale

0.458

High

1154496

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

497185

TAU
Microtubule-associated protein tau

1

1

Small-scale

0.445

High

846998

SMCA4
Transcription activator BRG1

1

1

Small-scale

0.445

High

1154474

SMRC2
SWI/SNF complex subunit SMARCC2

1

4

Small-scale

0.445

High

418978

TPM3
Tropomyosin alpha-3 chain

1

2

Small-scale

0.437

High

434393

TPM2
Tropomyosin beta chain

1

2

Small-scale

0.437

High

451269

TPM1
Tropomyosin alpha-1 chain

1

2

Small-scale

0.437

High

580659

ML12A
Myosin regulatory light chain 12A

1

1

Small-scale

0.437

High

624358

MYL9
Myosin regulatory light polypeptide 9

1

1

Small-scale

0.437

High

932997

ACTS
Actin, alpha skeletal muscle

1

1

Small-scale

0.437

High

933236

TBA1B
Tubulin alpha-1B chain

1

1

Small-scale

0.437

High

1154471

MYH14
Myosin-14

1

2

Small-scale

0.437

High

1154476

BPIB1
BPI fold-containing family B member 1

1

1

Small-scale

0.437

High

1154489

BPIA1
BPI fold-containing family A member 1

1

1

Small-scale

0.437

High

1154469

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.426

High

1154485

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

834420

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.288

High

413957

GELS
Gelsolin

1

0

High-throughput

0.268

Low

609356

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

232683

TBCD4
TBC1 domain family member 4

1

0

Small-scale

0.265

Low

275580

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

Small-scale

0.249

Low

361355

APOA1
Apolipoprotein A-I

1

0

Small-scale

0.249

Low

361878

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

Small-scale

0.249

Low

443587

VIME
Vimentin

1

0

Small-scale

0.249

Low

499834

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.249

Low

603186

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

Small-scale

0.249

Low

660566

GRN
Progranulin

1

0

Small-scale

0.249

Low

882365

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

Small-scale

0.249

Low

891543

MYL6
Myosin light polypeptide 6

1

0

Small-scale

0.249

Low

901585

LYSC
Lysozyme C

1

0

Small-scale

0.249

Low

946547

DCD
Dermcidin

1

0

Small-scale

0.249

Low

950506

ARF1
ADP-ribosylation factor 1

1

0

Small-scale

0.249

Low

960839

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.249

Low

1068568

PLEC
Plectin

1

0

Small-scale

0.249

Low

1154492

CALL5
Calmodulin-like protein 5

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024