Protein: GCN4
General control transcription factor GCN4 (Amino acid biosynthesis regulatory protein) (General control protein GCN4)

Gene: GCN4
Organism: Saccharomyces cerevisiae S288C
Interactions: 70
UniProt ID: P03069

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001094 - TFIID-class transcription factor complex binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

395208

GCN4
General control transcription factor GCN4

16

0

Small-scale

0.932

High

395223

MED15
Mediator of RNA polymerase II transcription subunit 15

7

0

Small-scale

0.719

High

395235

SPT7
SAGA complex subunit SPT7

4

1

Small-scale

0.688

High

395225

SNF2
Transcription regulatory protein SNF2

4

1

Small-scale

0.680

High

395220

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

5

0

Small-scale

0.674

High

395261

ADA2
SAGA complex subunit ADA2

4

0

Small-scale

0.669

High

395265

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

4

0

Small-scale

0.660

High

395219

PHO85
Cyclin-dependent protein kinase PHO85

3

1

Small-scale

0.655

High

395264

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

4

0

Small-scale

0.654

High

395211

SPT3
SAGA complex subunit SPT3

3

1

Small-scale

0.647

High

395217

TBP
TATA-box-binding protein

3

0

Small-scale

0.641

High

395253

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.639

High

395241

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

3

0

Small-scale

0.623

High

395238

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

3

0

Small-scale

0.622

High

395213

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

3

0

Small-scale

0.619

High

395233

MED20
Mediator of RNA polymerase II transcription subunit 20

3

0

Small-scale

0.613

High

395243

RPN10
26S proteasome regulatory subunit RPN10

2

0

Small-scale

0.609

High

395246

SSB2
Ribosome-associated molecular chaperone SSB2

3

0

Small-scale

0.597

High

395245

SSN3
Meiotic mRNA stability protein kinase SSN3

2

2

Small-scale

0.595

High

395212

CDC4
Cell division control protein 4

2

0

Small-scale

0.579

High

395232

PRS6A
26S proteasome regulatory subunit 6A

2

0

Small-scale

0.577

High

395222

SNF6
Transcription regulatory protein SNF6

2

0

Small-scale

0.577

High

395256

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

2

0

Small-scale

0.576

High

395216

RAP1
DNA-binding protein RAP1

1

0

Small-scale

0.571

High

395230

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.559

High

395259

SNF12
Transcription regulatory protein SNF12

2

0

Small-scale

0.559

High

395273

AHC1
Protein AHC1

2

0

Small-scale

0.559

High

154292

MBF1
Multiprotein-bridging factor 1

1

0

Small-scale

0.537

High

395247

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

Small-scale

0.537

High

395263

GCN5
Histone acetyltransferase GCN5

1

0

Small-scale

0.494

High

395262

MET31
Transcriptional regulator MET31

1

0

High-throughput

0.486

High

364207

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.481

High

395215

TAF13
Transcription initiation factor TFIID subunit 13

1

1

Small-scale

0.481

High

395260

AF9
Protein AF-9 homolog

1

1

High-throughput

0.481

High

395209

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.480

High

395210

UBC2
Ubiquitin-conjugating enzyme E2 2

1

0

Small-scale

0.480

High

395227

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

Small-scale

0.480

High

395240

YNG2
Chromatin modification-related protein YNG2

1

0

Small-scale

0.480

High

395250

EPL1
Enhancer of polycomb-like protein 1

1

0

Small-scale

0.480

High

395251

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

Small-scale

0.480

High

395258

INO80
Chromatin-remodeling ATPase INO80

1

0

Small-scale

0.480

High

395231

STH1
Nuclear protein STH1/NPS1

1

1

Small-scale

0.479

High

395236

TAF14
Transcription initiation factor TFIID subunit 14

1

1

Small-scale

0.479

High

395218

GCN2
eIF-2-alpha kinase GCN2

1

0

Small-scale

0.460

High

395228

TF2B
Transcription initiation factor IIB

1

0

Small-scale

0.460

High

395237

CCL1
Cyclin CCL1

1

0

Small-scale

0.460

High

395248

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

Small-scale

0.460

High

395257

MCM6
DNA replication licensing factor MCM6

1

0

Small-scale

0.460

High

395267

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.460

High

395269

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.460

High

395214

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

395221

GLN3
Nitrogen regulatory protein GLN3

1

0

Small-scale

0.458

High

395226

CDC48
Cell division control protein 48

1

0

Small-scale

0.458

High

395229

NGG1
SAGA complex subunit NGG1

1

0

Small-scale

0.458

High

395242

SOL3
6-phosphogluconolactonase 3

1

0

High-throughput

0.458

High

395252

TAF1
Transcription initiation factor TFIID subunit 1

1

0

Small-scale

0.458

High

395254

SPT20
SAGA complex subunit SPT20

1

0

Small-scale

0.458

High

395268

MED2
Mediator of RNA polymerase II transcription subunit 2

1

0

Small-scale

0.458

High

395270

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.458

High

395272

ARP7
Actin-related protein 7

1

0

Small-scale

0.458

High

395239

APN2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

0

High-throughput

0.438

High

395255

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.391

High

395244

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.269

Low

395271

RPN6
26S proteasome regulatory subunit RPN6

1

0

High-throughput

0.265

Low

395234

CASP
Protein CASP

1

0

High-throughput

0.251

Low

150121

YH145
Putative uncharacterized protein YHR145C

1

0

High-throughput

0.238

Low

395249

RGD2
Rho-GTPase-activating protein RGD2

1

0

High-throughput

0.238

Low

395266

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.238

Low

395224

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025