Protein: SPT20
SAGA complex subunit SPT20 (Suppressor of Ty protein 20) (Transcription factor SPT20)

Gene: SPT20
Organism: Saccharomyces cerevisiae S288C
Interactions: 115
UniProt ID: P50875

Gene Ontology (top 5):
GO:0000124 - SAGA complex
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006325 - chromatin organization
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

898200

HFI1
SAGA complex subunit HFI1

14

0

Small-scale

0.933

High

793955

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

12

0

Small-scale

0.928

High

898194

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

11

0

Small-scale

0.925

High

762988

SPT7
SAGA complex subunit SPT7

18

1

Small-scale

0.763

High

898185

ADA2
SAGA complex subunit ADA2

18

0

Small-scale

0.732

High

898181

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

13

0

Small-scale

0.728

High

898188

GCN5
Histone acetyltransferase GCN5

12

0

Small-scale

0.727

High

807245

SPT8
SAGA complex subunit SPT8

12

0

Small-scale

0.727

High

898182

SGF73
SAGA complex subunit SGF73

12

0

Small-scale

0.726

High

449462

SPT3
SAGA complex subunit SPT3

12

0

Small-scale

0.726

High

898191

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

12

0

Small-scale

0.726

High

738163

NGG1
SAGA complex subunit NGG1

10

0

Small-scale

0.725

High

805197

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

11

0

Small-scale

0.725

High

898199

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

11

0

Small-scale

0.723

High

893314

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

10

0

Small-scale

0.720

High

898187

SGF11
SAGA complex subunit SGF11

9

0

Small-scale

0.719

High

676656

SGF29
SAGA complex subunit SGF29

8

0

Small-scale

0.718

High

898207

SUS1
SAGA complex subunit SUS1

7

0

Small-scale

0.714

High

898180

SPT20
SAGA complex subunit SPT20

3

0

Small-scale

0.628

High

561500

TBP
TATA-box-binding protein

3

0

Small-scale

0.606

High

734445

BTAF1
TATA-binding protein-associated factor MOT1

2

1

Small-scale

0.584

High

626521

AP1
AP-1-like transcription factor YAP1

2

0

High-throughput

0.576

High

545540

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

Small-scale

0.571

High

524540

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.552

High

707627

TF2B
Transcription initiation factor IIB

2

0

High-throughput

0.551

High

359036

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.536

High

452748

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.513

High

619438

MED14
Mediator of RNA polymerase II transcription subunit 14

1

0

High-throughput

0.513

High

898203

HAL9
Halotolerance protein 9

1

0

High-throughput

0.513

High

359501

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.489

High

383157

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.489

High

427720

RLA2
Large ribosomal subunit protein P2A

1

1

High-throughput

0.489

High

408483

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

735524

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

Small-scale

0.480

High

858443

TAF1
Transcription initiation factor TFIID subunit 1

1

0

Small-scale

0.480

High

527157

HSP72
Heat shock protein SSA2

1

2

Small-scale

0.479

High

745809

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

800732

RCK1
Serine/threonine-protein kinase RCK1

1

1

High-throughput

0.479

High

395254

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.458

High

736680

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

737907

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.458

High

744320

CHD1
Chromo domain-containing protein 1

1

0

Small-scale

0.458

High

763939

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

865673

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

898183

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

898190

TAF8
Transcription initiation factor TFIID subunit 8

1

0

High-throughput

0.458

High

898192

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

898196

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

898202

YRA1
RNA annealing protein YRA1

1

0

Small-scale

0.458

High

898206

NOT5
General negative regulator of transcription subunit 5

1

0

Small-scale

0.458

High

481687

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

504606

YL12B
Transposon Ty1-LR2 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

741966

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

819248

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

898201

YG11B
Transposon Ty1-GR1 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

402055

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.426

High

419808

H2A2
Histone H2A.2

1

0

High-throughput

0.426

High

448193

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.426

High

453972

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.426

High

564665

STE12
Protein STE12

1

0

High-throughput

0.426

High

584928

TRM1
tRNA

1

0

High-throughput

0.426

High

590675

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

597208

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

645620

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

670296

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.426

High

671537

SWI4
Regulatory protein SWI4

1

0

High-throughput

0.426

High

679867

CDC48
Cell division control protein 48

1

0

High-throughput

0.426

High

694592

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

754223

MSN4
Zinc finger protein MSN4

1

0

High-throughput

0.426

High

779080

EF1G2
Elongation factor 1-gamma 2

1

0

High-throughput

0.426

High

781766

SET3
SET domain-containing protein 3

1

0

High-throughput

0.426

High

811351

CAJ1
Protein CAJ1

1

0

High-throughput

0.426

High

898184

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.426

High

898186

IMA1
Importin subunit alpha

1

0

High-throughput

0.426

High

898193

PPN1
Endopolyphosphatase

1

0

High-throughput

0.426

High

898197

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.426

High

898198

THP1
Nuclear mRNA export protein THP1

1

0

Small-scale

0.426

High

898204

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

898205

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.426

High

427588

RLA1
Large ribosomal subunit protein P1A

1

1

High-throughput

0.407

High

510650

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

528844

RLA3
Large ribosomal subunit protein P1B

1

1

High-throughput

0.407

High

577323

NSP1
Nucleoporin NSP1

1

1

High-throughput

0.407

High

738489

NUP2
Nucleoporin NUP2

1

1

High-throughput

0.407

High

763464

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.407

High

898195

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

4

High-throughput

0.407

High

427358

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.279

Low

569819

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.279

Low

781220

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.279

Low

898189

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.279

Low

692400

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.261

Low

376320

YPT1
GTP-binding protein YPT1

1

0

Small-scale

0.249

Low

513722

RL2A
Large ribosomal subunit protein uL2A

1

0

High-throughput

0.249

Low

514316

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.249

Low

780618

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.238

Low

358273

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.232

Low

386784

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

477592

MYO1
Myosin-1

1

0

High-throughput

0.232

Low

511987

RS30B
Small ribosomal subunit protein eS30B

1

0

High-throughput

0.232

Low

572619

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.232

Low

579731

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

597506

EF3A
Elongation factor 3A

1

0

High-throughput

0.232

Low

603511

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.232

Low

605328

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

626811

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

639450

DIT1
Spore wall maturation protein DIT1

1

0

High-throughput

0.232

Low

656332

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

0

High-throughput

0.232

Low

672330

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.232

Low

734152

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

738406

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.232

Low

752501

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

864298

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low

865001

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

868428

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025