Protein: UTP6
U3 small nucleolar RNA-associated protein 6 (U3 snoRNA-associated protein 6) (U three protein 6)

Gene: UTP6
Organism: Saccharomyces cerevisiae S288C
Interactions: 155
UniProt ID: Q02354

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1036410

UTP21
U3 small nucleolar RNA-associated protein 21

10

5

Small-scale

0.758

High

678443

PWP2
Periodic tryptophan protein 2

9

2

Small-scale

0.754

High

1036409

UTP13
U3 small nucleolar RNA-associated protein 13

7

5

Small-scale

0.751

High

823373

UTP18
U3 small nucleolar RNA-associated protein 18

11

0

Small-scale

0.727

High

1036401

DHR1
Probable ATP-dependent RNA helicase DHR1

6

6

Small-scale

0.727

High

1036432

UTP12
U3 small nucleolar RNA-associated protein 12

5

2

Small-scale

0.720

High

1036417

NOC4
Nucleolar complex protein 4

9

0

Small-scale

0.720

High

798290

ENP1
Essential nuclear protein 1

8

0

Small-scale

0.715

High

1036437

NOP58
Nucleolar protein 58

5

1

Small-scale

0.714

High

677532

KRR1
KRR1 small subunit processome component

6

0

High-throughput

0.705

High

865156

MPP10
U3 small nucleolar RNA-associated protein MPP10

5

0

Small-scale

0.698

High

817614

UTP7
U3 small nucleolar RNA-associated protein 7

4

2

High-throughput

0.697

High

1036419

UTP4
U3 small nucleolar RNA-associated protein 4

4

2

Small-scale

0.694

High

1036397

UTP6
U3 small nucleolar RNA-associated protein 6

4

1

Small-scale

0.693

High

918805

UTP22
U3 small nucleolar RNA-associated protein 22

5

0

High-throughput

0.691

High

844582

UTP10
U3 small nucleolar RNA-associated protein 10

5

0

High-throughput

0.684

High

747039

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

3

1

High-throughput

0.667

High

754321

DCA13
Protein SOF1

3

3

High-throughput

0.667

High

1036398

UTP17
NET1-associated nuclear protein 1

3

3

High-throughput

0.667

High

1036402

UTP15
U3 small nucleolar RNA-associated protein 15

3

2

High-throughput

0.667

High

1036406

RRP5
rRNA biogenesis protein RRP5

3

3

High-throughput

0.667

High

1036416

RRP9
Ribosomal RNA-processing protein 9

3

4

High-throughput

0.667

High

924611

NAT10
RNA cytidine acetyltransferase

4

0

High-throughput

0.657

High

1036429

SAS10
Something about silencing protein 10

3

0

Small-scale

0.649

High

753537

RS3A1
Small ribosomal subunit protein eS1A

3

0

High-throughput

0.638

High

763612

UTP20
U3 small nucleolar RNA-associated protein 20

3

0

High-throughput

0.638

High

806561

UTP9
U3 small nucleolar RNA-associated protein 9

3

0

High-throughput

0.638

High

1036414

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

3

0

High-throughput

0.638

High

1036405

UTP14
U3 small nucleolar RNA-associated protein 14

3

0

High-throughput

0.630

High

1036427

BMS1
Ribosome biogenesis protein BMS1

3

0

High-throughput

0.630

High

852592

ROK1
ATP-dependent RNA helicase ROK1

3

0

High-throughput

0.628

High

871042

NOL10
Ribosome biogenesis protein ENP2

3

0

High-throughput

0.628

High

1036412

SGD1
Suppressor of glycerol defect protein 1

2

1

High-throughput

0.614

High

513168

RS8A
Small ribosomal subunit protein eS8A

3

0

High-throughput

0.613

High

919157

UTP8
U3 small nucleolar RNA-associated protein 8

3

0

Small-scale

0.613

High

818332

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

2

0

High-throughput

0.588

High

923241

ESF2
Pre-rRNA-processing protein ESF2

2

0

High-throughput

0.588

High

1036415

ESF1
Pre-rRNA-processing protein ESF1

2

0

High-throughput

0.588

High

1036436

RRP36
rRNA biogenesis protein RRP36

2

0

High-throughput

0.588

High

1036441

NOP14
Nucleolar complex protein 14

2

0

High-throughput

0.588

High

819560

SSB2
Ribosome-associated molecular chaperone SSB2

3

3

High-throughput

0.587

High

1036411

MRD1
Multiple RNA-binding domain-containing protein 1

2

0

Small-scale

0.585

High

864500

MTR4
ATP-dependent RNA helicase DOB1

2

5

Small-scale

0.584

High

1036435

NOP56
Nucleolar protein 56

2

1

High-throughput

0.584

High

427412

RLA0
Large ribosomal subunit protein uL10

2

0

High-throughput

0.576

High

585350

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.576

High

782418

RPF2
Ribosome biogenesis protein RPF2

2

0

High-throughput

0.576

High

923974

CSL4
Exosome complex component CSL4

2

0

High-throughput

0.559

High

779152

DHR2
Probable ATP-dependent RNA helicase DHR2

1

8

High-throughput

0.541

High

503195

RS22A
Small ribosomal subunit protein uS8A

2

1

High-throughput

0.533

High

851010

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.518

High

918610

SLX9
Ribosome biogenesis protein SLX9

1

0

High-throughput

0.518

High

924127

SQS1
Protein SQS1

1

0

High-throughput

0.518

High

524892

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.504

High

757409

TFC3
Transcription factor tau 138 kDa subunit

1

0

High-throughput

0.493

High

722185

XPO1
Exportin-1

1

3

High-throughput

0.489

High

149909

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

802895

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.479

High

863125

RRP41
Exosome complex component SKI6

1

2

High-throughput

0.479

High

918883

RRP46
Exosome complex component RRP46

1

2

High-throughput

0.479

High

918959

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

924178

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

High-throughput

0.479

High

1036400

UTP5
U3 small nucleolar RNA-associated protein 5

1

3

High-throughput

0.479

High

1036408

RRP45
Exosome complex component RRP45

1

2

High-throughput

0.479

High

1036418

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

1036433

RRP42
Exosome complex component RRP42

1

2

High-throughput

0.479

High

1036434

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.479

High

481733

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.470

High

893032

HSV2
SVP1-like protein 2

1

2

High-throughput

0.470

High

435299

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

436119

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

442067

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

512602

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

514786

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

632722

DBP4
ATP-dependent RNA helicase HCA4

1

0

High-throughput

0.458

High

672933

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

673217

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

674785

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

689270

RL16B
Large ribosomal subunit protein uL13B

1

0

High-throughput

0.458

High

689614

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

747534

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

758399

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

778490

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

782093

RL1D1
Ribosome biogenesis protein UTP30

1

0

High-throughput

0.458

High

802335

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

804739

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.458

High

804948

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

808295

RRP8
25S rRNA

1

0

High-throughput

0.458

High

825072

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

825551

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

826202

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

864947

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

871115

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

874228

TRF5
Poly(A) RNA polymerase protein 1

1

0

Small-scale

0.458

High

874478

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

919754

PXR1
Protein PXR1

1

0

Small-scale

0.458

High

925185

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.458

High

1036399

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

1036407

FCF1
rRNA-processing protein FCF1

1

0

High-throughput

0.458

High

1036420

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

1036421

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

1036422

RRP44
Exosome complex exonuclease DIS3

1

0

High-throughput

0.458

High

1036423

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

1036425

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

1036428

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

1036430

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

1036438

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

1036439

EFG1P
rRNA-processing protein EFG1

1

0

High-throughput

0.458

High

1036442

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

645971

DBF2
Cell cycle protein kinase DBF2

1

2

High-throughput

0.437

High

740001

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

1

High-throughput

0.437

High

792198

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.437

High

925239

ARP5
Actin-related protein 5

1

1

High-throughput

0.437

High

1033513

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

1036440

RS22B
Small ribosomal subunit protein uS8B

1

1

High-throughput

0.437

High

531856

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.407

High

545958

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.407

High

799763

IF5
Eukaryotic translation initiation factor 5

2

0

High-throughput

0.307

High

751625

PPZ2
Serine/threonine-protein phosphatase PP-Z2

1

0

High-throughput

0.269

Low

814257

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.269

Low

863179

YPP1
Cargo-transport protein YPP1

1

0

High-throughput

0.269

Low

1036431

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.269

Low

383851

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

410293

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

432674

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.249

Low

433802

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

455217

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

504374

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

558841

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

694165

CDC15
Cell division control protein 15

1

0

High-throughput

0.249

Low

709936

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

804867

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.249

Low

808542

TEM1
Protein TEM1

1

0

High-throughput

0.249

Low

812586

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

826057

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.249

Low

918432

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

924997

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.249

Low

1036403

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

1036413

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

1036424

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

1036426

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

780631

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.238

Low

830017

LYS14
Lysine biosynthesis regulatory protein LYS14

1

0

High-throughput

0.238

Low

365158

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low

393200

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.232

Low

394835

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

531387

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.232

Low

575504

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

592446

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

816737

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

824525

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.232

Low

835870

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.232

Low

836855

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

1036404

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025