Protein: BOP1
Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein)

Gene: BOP1
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q14137

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

139530

PESC
Pescadillo homolog

11

4

Small-scale

0.976

High

1121081

WDR12
Ribosome biogenesis protein WDR12

6

20

Small-scale

0.943

High

1121035

RL7L
Ribosomal protein uL30-like

3

6

Small-scale

0.847

High

182293

WDR46
WD repeat-containing protein 46

2

18

High-throughput

0.789

High

1121067

DDX27
Probable ATP-dependent RNA helicase DDX27

2

14

Small-scale

0.754

High

1121089

ANLN
Anillin

2

5

High-throughput

0.754

High

975687

RL7A
Large ribosomal subunit protein eL8

1

6

High-throughput

0.691

High

1121053

WDR48
WD repeat-containing protein 48

1

19

High-throughput

0.691

High

1121105

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.691

High

447005

NPM
Nucleophosmin

3

4

High-throughput

0.667

High

1121071

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.656

High

978924

RS6
Small ribosomal subunit protein eS6

3

2

High-throughput

0.643

High

259933

BRD4
Bromodomain-containing protein 4

3

13

High-throughput

0.640

High

345797

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

12

High-throughput

0.640

High

371997

MYC
Myc proto-oncogene protein

3

14

High-throughput

0.640

High

288648

NPM3
Nucleoplasmin-3

2

4

High-throughput

0.628

High

1121086

WDR55
WD repeat-containing protein 55

2

19

High-throughput

0.628

High

194186

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.618

High

224287

BUB3
Mitotic checkpoint protein BUB3

1

19

Small-scale

0.618

High

980757

H2B1C
Histone H2B type 1-C/E/F/G/I

1

7

High-throughput

0.618

High

998305

H31
Histone H3.1

1

10

High-throughput

0.618

High

1016845

H33
Histone H3.3

1

10

High-throughput

0.618

High

1121022

BOP1
Ribosome biogenesis protein BOP1

1

16

Small-scale

0.618

High

1121024

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.618

High

1121038

WDR74
WD repeat-containing protein 74

1

20

Small-scale

0.618

High

1121052

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1121064

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

19

High-throughput

0.618

High

1121079

DDX23
Probable ATP-dependent RNA helicase DDX23

1

7

High-throughput

0.618

High

1121087

RC3H2
Roquin-2

1

12

High-throughput

0.618

High

1121092

NLE1
Notchless protein homolog 1

1

18

High-throughput

0.618

High

1121096

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

6

High-throughput

0.618

High

1121103

FBW1A
F-box/WD repeat-containing protein 1A

1

17

High-throughput

0.618

High

1121030

IF16
Gamma-interferon-inducible protein 16

2

7

High-throughput

0.611

High

169249

CASQ2
Calsequestrin-2

3

9

High-throughput

0.609

High

1121068

PRR11
Proline-rich protein 11

2

0

High-throughput

0.602

High

72772

B0UZZ8
WD repeat-containing protein 46

1

18

High-throughput

0.575

High

396088

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

157355

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.553

High

418978

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.553

High

1121040

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

1121047

AHI1
Jouberin

1

19

Small-scale

0.553

High

1121085

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.553

High

1121098

FBW1B
F-box/WD repeat-containing protein 11

1

18

High-throughput

0.553

High

286979

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

12

High-throughput

0.536

High

428759

RLA0
Large ribosomal subunit protein uL10

1

7

High-throughput

0.536

High

521681

H14
Histone H1.4

1

6

High-throughput

0.536

High

595770

H13
Histone H1.3

1

6

High-throughput

0.536

High

615784

RL17
Large ribosomal subunit protein uL22

1

2

High-throughput

0.536

High

624056

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

3

High-throughput

0.536

High

625373

CSK22
Casein kinase II subunit alpha'

1

9

High-throughput

0.536

High

635316

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

1

High-throughput

0.536

High

686152

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.536

High

785158

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.536

High

809631

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.536

High

824138

RL13A
Large ribosomal subunit protein uL13

1

3

High-throughput

0.536

High

833107

MNDA
Myeloid cell nuclear differentiation antigen

1

7

High-throughput

0.536

High

842367

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

898645

RL14
Large ribosomal subunit protein eL14

1

2

High-throughput

0.536

High

985654

RL11
Large ribosomal subunit protein uL5

1

3

High-throughput

0.536

High

997707

CSK21
Casein kinase II subunit alpha

1

9

High-throughput

0.536

High

1006390

SRPK2
SRSF protein kinase 2

1

13

High-throughput

0.536

High

1099072

SRSF5
Serine/arginine-rich splicing factor 5

1

9

High-throughput

0.536

High

1099341

SRSF6
Serine/arginine-rich splicing factor 6

1

13

High-throughput

0.536

High

1112013

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.536

High

1113075

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1121045

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

9

High-throughput

0.536

High

1121059

RAD50
DNA repair protein RAD50

1

14

High-throughput

0.536

High

1121066

AURKB
Aurora kinase B

1

4

High-throughput

0.536

High

1121095

LYAR
Cell growth-regulating nucleolar protein

1

3

High-throughput

0.536

High

1121099

ZN346
Zinc finger protein 346

1

1

High-throughput

0.536

High

1121101

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

272158

OBSL1
Obscurin-like protein 1

2

4

High-throughput

0.533

High

1121029

ACAP1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

1

0

Small-scale

0.517

High

566665

PDIA4
Protein disulfide-isomerase A4

1

10

High-throughput

0.515

High

732584

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.515

High

882487

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.515

High

179345

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.513

High

344936

WIZ
Protein Wiz

1

0

High-throughput

0.513

High

788652

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

1121065

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

191639

MAGB2
Melanoma-associated antigen B2

1

3

High-throughput

0.489

High

239060

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.489

High

391250

FRIL
Ferritin light chain

1

3

High-throughput

0.489

High

849166

KSYK
Tyrosine-protein kinase SYK

1

3

High-throughput

0.489

High

1050991

FAK1
Focal adhesion kinase 1

1

6

High-throughput

0.489

High

1121043

PNM8A
Paraneoplastic antigen-like protein 8A

1

3

High-throughput

0.489

High

1121050

SYT2
Synaptotagmin-2

1

1

High-throughput

0.489

High

1121097

IL17B
Interleukin-17B

1

1

High-throughput

0.489

High

1121104

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.489

High

129067

MEN1
Menin

1

4

High-throughput

0.479

High

140911

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

190901

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

223025

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

274573

DNJB6
DnaJ homolog subfamily B member 6

1

8

High-throughput

0.479

High

330952

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

406167

MYCN
N-myc proto-oncogene protein

1

13

High-throughput

0.479

High

413812

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

429871

JUN
Transcription factor Jun

1

9

High-throughput

0.479

High

472731

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.479

High

588667

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

643831

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.479

High

695426

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

768159

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

770179

RL22
Large ribosomal subunit protein eL22

1

2

High-throughput

0.479

High

772793

MYH9
Myosin-9

1

2

Small-scale

0.479

High

810091

RL3
Large ribosomal subunit protein uL3

1

6

High-throughput

0.479

High

830714

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

879074

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

899894

FXR1
RNA-binding protein FXR1

1

10

High-throughput

0.479

High

951670

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.479

High

964937

WDR5
WD repeat-containing protein 5

1

15

High-throughput

0.479

High

984755

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

1035607

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.479

High

1121028

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

1121031

DUS5
Dual specificity protein phosphatase 5

1

1

High-throughput

0.479

High

1121033

HABP4
Intracellular hyaluronan-binding protein 4

1

2

High-throughput

0.479

High

1121034

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

1121036

IFIX
Pyrin and HIN domain-containing protein 1

1

7

High-throughput

0.479

High

1121037

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

4

Small-scale

0.479

High

1121042

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

1121044

ZCH18
Zinc finger CCCH domain-containing protein 18

1

12

High-throughput

0.479

High

1121049

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

1121051

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1121055

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1121056

NOC3L
Nucleolar complex protein 3 homolog

1

6

High-throughput

0.479

High

1121057

DNJC9
DnaJ homolog subfamily C member 9

1

10

High-throughput

0.479

High

1121058

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1121062

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

1121069

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

1121070

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

10

Small-scale

0.479

High

1121073

RANB9
Ran-binding protein 9

1

5

High-throughput

0.479

High

1121074

RING2
E3 ubiquitin-protein ligase RING2

1

14

High-throughput

0.479

High

1121075

NECD
Necdin

1

3

High-throughput

0.479

High

1121076

MBB1A
Myb-binding protein 1A

1

2

Small-scale

0.479

High

1121077

MTG1
Mitochondrial ribosome-associated GTPase 1

1

9

High-throughput

0.479

High

1121082

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1121088

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

6

High-throughput

0.479

High

1121090

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.479

High

1121091

MDN1
Midasin

1

13

Small-scale

0.479

High

1121093

RBM28
RNA-binding protein 28

1

6

High-throughput

0.479

High

1121102

NUDC
Nuclear migration protein nudC

1

9

High-throughput

0.479

High

1121106

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

3

High-throughput

0.470

High

1095084

KLF10
Krueppel-like factor 10

1

5

High-throughput

0.464

High

982658

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

1121032

MIDN
Midnolin

1

0

High-throughput

0.458

High

1121094

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

983387

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

2

High-throughput

0.445

High

1121023

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.445

High

76522

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

1

High-throughput

0.437

High

174757

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

4

High-throughput

0.437

High

241648

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.437

High

271705

HIP1R
Huntingtin-interacting protein 1-related protein

1

5

Small-scale

0.437

High

319754

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.437

High

400817

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.437

High

411908

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

1049148

RON
Macrophage-stimulating protein receptor

1

3

High-throughput

0.437

High

1121025

CUL7
Cullin-7

1

2

High-throughput

0.437

High

1121039

SYT10
Synaptotagmin-10

1

1

Small-scale

0.437

High

1121041

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1121054

NEK9
Serine/threonine-protein kinase Nek9

1

3

High-throughput

0.437

High

1121060

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.437

High

1121063

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.437

High

1121080

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1121100

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.437

High

58817

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.407

High

1121072

CI072
Guanine nucleotide exchange factor C9orf72

1

1

Small-scale

0.407

High

1121046

FMR1N
FMR1 neighbor protein

2

0

High-throughput

0.328

High

137441

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.279

Low

1121026

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1121027

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.249

Low

1121048

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1121061

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.249

Low

1121078

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

0

Small-scale

0.249

Low

1121083

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

1121084

MTRFR
Mitochondrial translation release factor in rescue

1

0

High-throughput

0.249

Low

516091

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025