Protein: SAP
Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]

Gene: SAP, PSAP
Organism: Homo sapiens
Interactions: 79
UniProt ID: P07602

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0005543 - phospholipid binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

458656

SAP
Prosaposin

2

1

Small-scale

0.790

High

458668

GRN
Progranulin

2

2

High-throughput

0.633

High

458716

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

458685

PAK1
Serine/threonine-protein kinase PAK 1

2

0

High-throughput

0.547

High

410527

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.541

High

458674

HSP13
Heat shock 70 kDa protein 13

1

3

High-throughput

0.541

High

458667

CALX
Calnexin

1

1

High-throughput

0.536

High

458687

SGCG
Gamma-sarcoglycan

1

0

High-throughput

0.518

High

458714

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

0

High-throughput

0.518

High

458658

CATB
Cathepsin B

1

2

High-throughput

0.515

High

421321

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

458675

KC1D
Casein kinase I isoform delta

1

3

High-throughput

0.515

High

361062

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

458663

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

458691

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.513

High

458710

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

458692

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.508

High

458690

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.494

High

458659

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.493

High

458682

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.486

High

458715

NLGN3
Neuroligin-3

1

0

Small-scale

0.486

High

458672

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.481

High

239673

PCDH7
Protocadherin-7

1

1

High-throughput

0.479

High

370137

CYTN
Cystatin-SN

1

1

Small-scale

0.479

High

400136

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

456175

CATD
Cathepsin D

1

3

Small-scale

0.479

High

458661

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

458662

MPRI
Cation-independent mannose-6-phosphate receptor

1

1

High-throughput

0.479

High

458679

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

458708

SORL
Sortilin-related receptor

1

1

High-throughput

0.479

High

181850

SMAD9
Mothers against decapentaplegic homolog 9

1

1

High-throughput

0.464

High

458684

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

Small-scale

0.460

High

164221

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

217725

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

327677

UBL3
Ubiquitin-like protein 3

1

0

Small-scale

0.458

High

458657

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

458664

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

458666

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

458671

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

458678

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

458689

CUL3
Cullin-3

1

0

High-throughput

0.458

High

458703

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

458705

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

1

0

High-throughput

0.458

High

458693

HSPB2
Heat shock protein beta-2

1

2

High-throughput

0.457

High

458670

TRY3
Trypsin-3

1

1

Small-scale

0.445

High

458676

KLK7
Kallikrein-7

1

1

Small-scale

0.445

High

458695

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

458698

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

Small-scale

0.437

High

458660

LEG1
Galectin-1

1

0

High-throughput

0.426

High

458665

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

458683

FGL1
Fibrinogen-like protein 1

1

0

High-throughput

0.426

High

458686

STF1
Steroidogenic factor 1

1

0

Small-scale

0.426

High

458700

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.426

High

458701

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.426

High

458711

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

458718

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

170622

CLGN
Calmegin

1

1

High-throughput

0.407

High

458681

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.407

High

354201

ZBED1
E3 SUMO-protein ligase ZBED1

3

0

High-throughput

0.348

High

458677

PEX5
Peroxisomal targeting signal 1 receptor

2

0

High-throughput

0.316

High

458707

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.316

High

458712

FBX6
F-box only protein 6

2

0

High-throughput

0.305

High

458696

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.282

High

458699

PRAG1
Inactive tyrosine-protein kinase PRAG1

1

0

High-throughput

0.282

High

458717

MAFF
Transcription factor MafF

1

0

High-throughput

0.282

High

458697

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

0

Small-scale

0.251

Low

370949

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

458669

CASPE
Caspase-14

1

0

Small-scale

0.249

Low

458673

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

458680

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.249

Low

458706

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.249

Low

458713

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

269986

XYLK
Glycosaminoglycan xylosylkinase

1

0

High-throughput

0.232

Low

458688

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

458694

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low

458702

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.232

Low

458704

NAT14
Probable N-acetyltransferase 14

1

0

High-throughput

0.232

Low

458709

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025