Protein: SPNS2
Sphingosine-1-phosphate transporter SPNS2 (Protein spinster homolog 2)

Gene: SPNS2
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q8IVW8

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0002920 - regulation of humoral immune response
GO:0003376 - sphingosine-1-phosphate receptor signaling pathway
GO:0005886 - plasma membrane
GO:0006869 - lipid transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

48686

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.445

High

173033

XPO1
Exportin-1

1

5

High-throughput

0.445

High

208532

PJA2
E3 ubiquitin-protein ligase Praja-2

1

4

High-throughput

0.445

High

258971

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.445

High

422517

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.445

High

465570

IGF1R
Insulin-like growth factor 1 receptor

1

3

High-throughput

0.445

High

914097

HXK2
Hexokinase-2

1

1

High-throughput

0.445

High

938583

PSA
Puromycin-sensitive aminopeptidase

1

2

High-throughput

0.445

High

1047619

NOTC2
Neurogenic locus notch homolog protein 2

1

2

High-throughput

0.445

High

1151573

TRIP6
Thyroid receptor-interacting protein 6

1

2

High-throughput

0.445

High

1204755

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

High-throughput

0.445

High

1219294

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.445

High

1309387

MIRO1
Mitochondrial Rho GTPase 1

1

11

High-throughput

0.445

High

1309393

GCN1
Stalled ribosome sensor GCN1

1

1

High-throughput

0.445

High

1309396

PDLI5
PDZ and LIM domain protein 5

1

2

High-throughput

0.445

High

1309398

IPO9
Importin-9

1

2

High-throughput

0.445

High

1309402

CAB45
45 kDa calcium-binding protein

1

1

High-throughput

0.445

High

186428

TM9S1
Transmembrane 9 superfamily member 1

1

0

High-throughput

0.426

High

261218

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

854473

KPB1
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform

1

0

High-throughput

0.426

High

861214

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.426

High

902998

MMP15
Matrix metalloproteinase-15

1

0

High-throughput

0.426

High

905613

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.426

High

943086

STX17
Syntaxin-17

1

0

High-throughput

0.426

High

1159740

OCLN
Occludin

1

0

High-throughput

0.426

High

1218426

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.426

High

1231842

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.426

High

1309388

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

0

High-throughput

0.426

High

1309390

MCLN3
Mucolipin-3

1

0

High-throughput

0.426

High

1309391

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.426

High

1309392

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.426

High

1309394

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.426

High

1309400

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.426

High

1309412

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.426

High

143657

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

1

High-throughput

0.407

High

189212

IPO8
Importin-8

1

2

High-throughput

0.407

High

214311

MSI1H
RNA-binding protein Musashi homolog 1

1

3

High-throughput

0.407

High

220943

XPOT
Exportin-T

1

5

High-throughput

0.407

High

262536

MCE1
mRNA-capping enzyme

1

1

High-throughput

0.407

High

273209

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

1

High-throughput

0.407

High

302885

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

1

High-throughput

0.407

High

621494

HXK1
Hexokinase-1

1

1

High-throughput

0.407

High

655857

TBG1
Tubulin gamma-1 chain

1

2

High-throughput

0.407

High

1177018

INF2
Inverted formin-2

1

1

High-throughput

0.407

High

1216514

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

1

1

High-throughput

0.407

High

1242075

TTC27
Tetratricopeptide repeat protein 27

1

2

High-throughput

0.407

High

1277494

MON2
Protein MON2 homolog

1

2

High-throughput

0.407

High

1277698

MYCPP
C-myc promoter-binding protein

1

1

High-throughput

0.407

High

1288030

PRP39
Pre-mRNA-processing factor 39

1

2

High-throughput

0.407

High

1309389

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

2

High-throughput

0.407

High

1309403

RN126
E3 ubiquitin-protein ligase RNF126

1

4

High-throughput

0.407

High

1309404

CLPB
Mitochondrial disaggregase

1

3

High-throughput

0.407

High

1309405

XPO5
Exportin-5

1

8

High-throughput

0.407

High

1309409

PANK4
4'-phosphopantetheine phosphatase

1

1

High-throughput

0.407

High

1309410

CNIH4
Protein cornichon homolog 4

1

1

High-throughput

0.407

High

1309413

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.407

High

353435

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

124399

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.232

Low

156148

TRAD1
TRAF-type zinc finger domain-containing protein 1

1

0

High-throughput

0.232

Low

209603

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.232

Low

333757

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

1

0

High-throughput

0.232

Low

585806

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

0

High-throughput

0.232

Low

1108594

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.232

Low

1215322

DCAF8
DDB1- and CUL4-associated factor 8

1

0

High-throughput

0.232

Low

1272929

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

0

High-throughput

0.232

Low

1309395

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

1

0

High-throughput

0.232

Low

1309397

ABHEB
Putative protein-lysine deacylase ABHD14B

1

0

High-throughput

0.232

Low

1309399

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.232

Low

1309401

MEP50
Methylosome protein WDR77

1

0

High-throughput

0.232

Low

1309406

INO1
Inositol-3-phosphate synthase 1

1

0

High-throughput

0.232

Low

1309407

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.232

Low

1309408

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.232

Low

1309411

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.232

Low

1309414

PLAP
Phospholipase A-2-activating protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025