Protein: MED9
Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9)

Gene: MED9
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q9NWA0

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1446524

MED4
Mediator of RNA polymerase II transcription subunit 4

9

1

Small-scale

0.977

High

1151299

MED1
Mediator of RNA polymerase II transcription subunit 1

9

0

Small-scale

0.923

High

1108407

MED21
Mediator of RNA polymerase II transcription subunit 21

9

0

Small-scale

0.922

High

881615

CDK8
Cyclin-dependent kinase 8

13

2

Small-scale

0.761

High

1416406

CDK19
Cyclin-dependent kinase 19

8

2

High-throughput

0.752

High

1372205

MED12
Mediator of RNA polymerase II transcription subunit 12

6

1

Small-scale

0.732

High

1451137

MED13
Mediator of RNA polymerase II transcription subunit 13

6

1

Small-scale

0.730

High

49025

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.722

High

1414147

MED18
Mediator of RNA polymerase II transcription subunit 18

7

0

Small-scale

0.720

High

219522

MED7
Mediator of RNA polymerase II transcription subunit 7

7

0

Small-scale

0.717

High

1450380

MED17
Mediator of RNA polymerase II transcription subunit 17

7

0

Small-scale

0.715

High

239622

MED14
Mediator of RNA polymerase II transcription subunit 14

5

1

Small-scale

0.712

High

666919

CCNC
Cyclin-C

5

1

High-throughput

0.712

High

1259073

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

5

1

Small-scale

0.712

High

1149715

MED22
Mediator of RNA polymerase II transcription subunit 22

6

0

Small-scale

0.705

High

336034

MED26
Mediator of RNA polymerase II transcription subunit 26

6

0

Small-scale

0.701

High

1413635

MED10
Mediator of RNA polymerase II transcription subunit 10

6

0

Small-scale

0.701

High

1436780

MED20
Mediator of RNA polymerase II transcription subunit 20

6

0

Small-scale

0.701

High

1451133

MED29
Mediator of RNA polymerase II transcription subunit 29

5

0

Small-scale

0.691

High

1391341

MED8
Mediator of RNA polymerase II transcription subunit 8

5

0

Small-scale

0.688

High

1431400

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.688

High

282424

MED24
Mediator of RNA polymerase II transcription subunit 24

5

0

Small-scale

0.686

High

287824

MED6
Mediator of RNA polymerase II transcription subunit 6

5

0

Small-scale

0.682

High

621991

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

0

High-throughput

0.670

High

1451135

MED11
Mediator of RNA polymerase II transcription subunit 11

4

0

Small-scale

0.670

High

1393383

MED30
Mediator of RNA polymerase II transcription subunit 30

4

0

Small-scale

0.667

High

1451147

MED31
Mediator of RNA polymerase II transcription subunit 31

4

0

Small-scale

0.667

High

667481

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

0

High-throughput

0.664

High

723117

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

0

High-throughput

0.664

High

1401571

MED15
Mediator of RNA polymerase II transcription subunit 15

4

0

High-throughput

0.664

High

1241417

MED27
Mediator of RNA polymerase II transcription subunit 27

4

0

Small-scale

0.661

High

1451139

MED23
Mediator of RNA polymerase II transcription subunit 23

4

0

Small-scale

0.661

High

1451145

MED16
Mediator of RNA polymerase II transcription subunit 16

4

0

Small-scale

0.661

High

621770

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

0

High-throughput

0.638

High

976163

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

0

High-throughput

0.638

High

1259286

MED25
Mediator of RNA polymerase II transcription subunit 25

3

0

Small-scale

0.634

High

1295679

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

1

High-throughput

0.611

High

192871

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.602

High

912248

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.585

High

912140

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

0

High-throughput

0.559

High

1313063

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.559

High

138776

IMA4
Importin subunit alpha-4

1

1

High-throughput

0.536

High

1451132

MED9
Mediator of RNA polymerase II transcription subunit 9

2

0

Small-scale

0.528

High

801556

HSPA9
Stress-70 protein, mitochondrial

2

2

High-throughput

0.521

High

316452

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.513

High

923555

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

959074

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

1025151

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.513

High

1163245

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1239679

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.513

High

1287328

TAD2B
Transcriptional adapter 2-beta

1

0

High-throughput

0.513

High

1293426

CARM1
Histone-arginine methyltransferase CARM1

1

0

High-throughput

0.513

High

1353695

ZN384
Zinc finger protein 384

1

0

High-throughput

0.513

High

1387115

REPS1
RalBP1-associated Eps domain-containing protein 1

1

0

High-throughput

0.513

High

1438399

TAF9B
Transcription initiation factor TFIID subunit 9B

1

0

High-throughput

0.513

High

1451148

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

508715

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

244021

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

1

High-throughput

0.489

High

143295

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

474333

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.479

High

537998

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

765068

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

987240

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

1

High-throughput

0.479

High

1088058

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1133697

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.479

High

1153932

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

1154014

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

1212048

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

1

High-throughput

0.479

High

260528

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

397061

ESR1
Estrogen receptor

1

0

Small-scale

0.458

High

418755

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

0

High-throughput

0.458

High

463799

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.458

High

552711

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.458

High

687524

PTBP1
Polypyrimidine tract-binding protein 1

1

0

High-throughput

0.458

High

773290

MYH10
Myosin-10

1

0

High-throughput

0.458

High

787800

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

959996

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

980430

H4
Histone H4

1

0

High-throughput

0.458

High

986246

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.458

High

1089036

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1127194

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1257830

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1380199

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1434833

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1451142

RUVB1
RuvB-like 1

1

0

High-throughput

0.458

High

507390

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

High-throughput

0.445

High

761524

HS71L
Heat shock 70 kDa protein 1-like

1

1

High-throughput

0.445

High

899609

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.445

High

911132

IMA1
Importin subunit alpha-1

1

1

High-throughput

0.445

High

1134749

NUMA1
Nuclear mitotic apparatus protein 1

1

2

High-throughput

0.445

High

1141973

EEA1
Early endosome antigen 1

1

1

High-throughput

0.437

High

175792

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.426

High

447503

NPM
Nucleophosmin

1

0

High-throughput

0.426

High

837420

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

0

High-throughput

0.426

High

913412

MSH6
DNA mismatch repair protein Msh6

1

0

High-throughput

0.426

High

974483

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.426

High

996364

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.426

High

1144487

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.426

High

1160593

SMN
Survival motor neuron protein

1

0

High-throughput

0.426

High

1451136

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.426

High

1451141

DICER
Endoribonuclease Dicer

1

0

High-throughput

0.426

High

1451144

DDX52
Probable ATP-dependent RNA helicase DDX52

1

0

High-throughput

0.426

High

1451146

NOP58
Nucleolar protein 58

1

0

High-throughput

0.426

High

76442

B4DUB1
cyclin-dependent kinase

1

2

High-throughput

0.407

High

95761

E5RFK5
Cyclin-C

1

1

High-throughput

0.407

High

882188

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

1451138

GPN3
GPN-loop GTPase 3

2

0

High-throughput

0.313

High

352646

TCL1B
T-cell leukemia/lymphoma protein 1B

1

0

High-throughput

0.279

Low

452412

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.279

Low

567097

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

1366730

NEUG
Neurogranin

1

0

High-throughput

0.279

Low

1451140

STX8
Syntaxin-8

1

0

High-throughput

0.269

Low

423306

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

387567

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

569224

CD59
CD59 glycoprotein

1

0

High-throughput

0.249

Low

983596

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

0

High-throughput

0.249

Low

1232031

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1451134

TMOD3
Tropomodulin-3

1

0

High-throughput

0.249

Low

1451143

PKHA6
Pleckstrin homology domain-containing family A member 6

1

0

High-throughput

0.249

Low

347368

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.232

Low

533008

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.232

Low

954013

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.232

Low

1010727

DCD
Dermcidin

1

0

High-throughput

0.232

Low

1365775

GCN1
Stalled ribosome sensor GCN1

1

0

High-throughput

0.232

Low

1450536

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025