Protein: RPC4
DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog)

Gene: RPC4, POLR3D
Organism: Homo sapiens
Interactions: 90
UniProt ID: P05423

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005654 - nucleoplasm
GO:0005666 - RNA polymerase III complex
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

430652

RPC5
DNA-directed RNA polymerase III subunit RPC5

8

4

Small-scale

0.972

High

430653

RPC2
DNA-directed RNA polymerase III subunit RPC2

7

3

Small-scale

0.962

High

186358

RPC7
DNA-directed RNA polymerase III subunit RPC7

7

1

Small-scale

0.747

High

430663

RPC8
DNA-directed RNA polymerase III subunit RPC8

7

2

Small-scale

0.746

High

430645

RPC6
DNA-directed RNA polymerase III subunit RPC6

6

1

Small-scale

0.735

High

164998

RPC1
DNA-directed RNA polymerase III subunit RPC1

6

3

Small-scale

0.733

High

180208

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

6

3

Small-scale

0.733

High

430661

RPC10
DNA-directed RNA polymerase III subunit RPC10

6

3

Small-scale

0.729

High

430603

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

5

1

Small-scale

0.722

High

287429

RPC9
DNA-directed RNA polymerase III subunit RPC9

5

1

High-throughput

0.718

High

430620

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

5

1

Small-scale

0.718

High

430641

RPC3
DNA-directed RNA polymerase III subunit RPC3

5

1

Small-scale

0.718

High

430622

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

5

1

High-throughput

0.712

High

430640

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

4

1

High-throughput

0.697

High

430664

TF3C3
General transcription factor 3C polypeptide 3

3

2

High-throughput

0.662

High

430616

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

2

Small-scale

0.656

High

430659

GPN3
GPN-loop GTPase 3

5

1

High-throughput

0.654

High

430598

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

4

2

High-throughput

0.650

High

430656

UXT
Protein UXT

3

0

High-throughput

0.638

High

316338

RMP
Unconventional prefoldin RPB5 interactor 1

3

0

Small-scale

0.628

High

430609

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

3

High-throughput

0.618

High

430618

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

1

High-throughput

0.611

High

430646

RPAP3
RNA polymerase II-associated protein 3

2

1

High-throughput

0.611

High

430610

HXA10
Homeobox protein Hox-A10

1

1

High-throughput

0.541

High

430611

HXC9
Homeobox protein Hox-C9

1

1

High-throughput

0.541

High

64418

BDP1
Transcription factor TFIIIB component B'' homolog

1

1

High-throughput

0.536

High

430605

TBP
TATA-box-binding protein

1

1

High-throughput

0.536

High

430644

MAF1
Repressor of RNA polymerase III transcription MAF1 homolog

1

1

High-throughput

0.536

High

430648

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.536

High

211257

RFOX2
RNA binding protein fox-1 homolog 2

1

0

High-throughput

0.518

High

430601

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

0

High-throughput

0.518

High

430608

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.518

High

430613

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.518

High

430634

ZN496
Zinc finger protein 496

1

0

High-throughput

0.518

High

430638

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

0

High-throughput

0.518

High

430665

NR2E3
Photoreceptor-specific nuclear receptor

1

0

High-throughput

0.518

High

430604

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

430615

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

430630

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

430623

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.486

High

430624

MK11
Mitogen-activated protein kinase 11

1

0

High-throughput

0.486

High

185350

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

172403

XPO1
Exportin-1

1

1

High-throughput

0.479

High

339920

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

3

High-throughput

0.479

High

370922

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

405677

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

430602

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

430606

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

High-throughput

0.479

High

430614

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

3

High-throughput

0.479

High

430617

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

2

High-throughput

0.479

High

430621

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

2

High-throughput

0.479

High

430626

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

2

High-throughput

0.479

High

430636

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.479

High

430647

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

3

High-throughput

0.479

High

430650

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

2

High-throughput

0.479

High

430655

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

3

High-throughput

0.479

High

430660

KLH20
Kelch-like protein 20

1

0

Small-scale

0.460

High

190790

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

192774

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.458

High

259300

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

315014

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

430599

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

430600

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

430607

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

430612

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

430619

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

430625

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.458

High

430629

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

430632

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.458

High

430633

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

430643

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

430649

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

430657

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

430658

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.458

High

132904

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.426

High

430597

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

430631

RN169
E3 ubiquitin-protein ligase RNF169

1

0

Small-scale

0.426

High

430637

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

430654

PIHD1
PIH1 domain-containing protein 1

4

0

High-throughput

0.362

High

389594

RET4
Retinol-binding protein 4

2

0

High-throughput

0.328

High

430651

PDRG1
p53 and DNA damage-regulated protein 1

2

0

High-throughput

0.318

High

430639

RHXF2
Rhox homeobox family member 2

1

0

High-throughput

0.282

High

430596

DC8L2
DDB1- and CUL4-associated factor 8-like protein 2

1

0

High-throughput

0.279

Low

430628

TRM1L
tRNA

1

0

High-throughput

0.279

Low

430662

T22D4
TSC22 domain family protein 4

1

0

High-throughput

0.279

Low

182075

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.249

Low

293055

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

430627

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

430635

DAA10
Dynein axonemal assembly factor 10

1

0

High-throughput

0.249

Low

430642

S39A8
Metal cation symporter ZIP8

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025