Protein: NLRP3
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)

Gene: NLRP3
Organism: Mus musculus
Interactions: 45
UniProt ID: Q8R4B8

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002523 - leukocyte migration involved in inflammatory response
GO:0002526 - acute inflammatory response
GO:0002674 - negative regulation of acute inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1246900

ASC
Apoptosis-associated speck-like protein containing a CARD

12

16

Small-scale

0.971

High

1246901

NEK7
Serine/threonine-protein kinase Nek7

5

3

Small-scale

0.906

High

978116

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

5

Small-scale

0.665

High

1206793

KC1A
Casein kinase I isoform alpha

1

1

Small-scale

0.618

High

1246896

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

15

Small-scale

0.618

High

1246902

FLII
Protein flightless-1 homolog

1

8

Small-scale

0.618

High

805578

BRCC3
Lys-63-specific deubiquitinase BRCC36

2

4

Small-scale

0.584

High

1145356

SQSTM
Sequestosome-1

2

5

Small-scale

0.584

High

1246903

AMFR
E3 ubiquitin-protein ligase AMFR

1

2

Small-scale

0.561

High

1246904

PRKN
E3 ubiquitin-protein ligase parkin

1

13

Small-scale

0.561

High

667128

CASP1
Caspase-1

1

20

Small-scale

0.515

High

1246897

MAVS
Mitochondrial antiviral-signaling protein

1

2

Small-scale

0.515

High

57639

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

2

Small-scale

0.479

High

193448

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

2

Small-scale

0.479

High

580884

GSTP1
Glutathione S-transferase P 1

1

2

Small-scale

0.479

High

588732

BIP
Endoplasmic reticulum chaperone BiP

1

10

Small-scale

0.479

High

619025

IRF8
Interferon regulatory factor 8

1

7

High-throughput

0.479

High

780900

RL28
Large ribosomal subunit protein eL28

1

1

Small-scale

0.479

High

880548

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

3

Small-scale

0.479

High

884377

PCBP3
Poly(rC)-binding protein 3

1

4

Small-scale

0.479

High

923907

YBOX1
Y-box-binding protein 1

1

2

Small-scale

0.479

High

1112066

CBLB
E3 ubiquitin-protein ligase CBL-B

1

1

Small-scale

0.479

High

1112452

Q3UCL2
RING-type E3 ubiquitin transferase

1

12

Small-scale

0.479

High

1112920

FBW1A
F-box/WD repeat-containing protein 1A

1

2

Small-scale

0.479

High

1130846

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

4

Small-scale

0.479

High

1143836

TIF1B
Transcription intermediary factor 1-beta

1

6

Small-scale

0.479

High

1186458

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

Small-scale

0.479

High

1194997

TRI50
E3 ubiquitin-protein ligase TRIM50

1

13

Small-scale

0.479

High

1206333

TRI65
E3 ubiquitin-protein ligase TRIM65

1

20

Small-scale

0.479

High

1206347

ACTBL
Beta-actin-like protein 2

1

2

Small-scale

0.479

High

1206386

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.479

High

1207374

TRI14
Tripartite motif-containing protein 14

1

20

Small-scale

0.479

High

1207564

TRI47
E3 ubiquitin-protein ligase TRIM47

1

20

Small-scale

0.479

High

1246775

TRI31
E3 ubiquitin-protein ligase TRIM31

1

16

Small-scale

0.479

High

1246899

RN125
E3 ubiquitin-protein ligase RNF125

1

16

Small-scale

0.479

High

1195026

MFN1
Mitofusin-1

1

0

Small-scale

0.458

High

1246905

NFS1
Cysteine desulfurase

1

0

Small-scale

0.458

High

1246906

CLIC1
Chloride intracellular channel protein 1

1

0

Small-scale

0.458

High

815742

KSYK
Tyrosine-protein kinase SYK

1

5

Small-scale

0.445

High

1129552

DIRA2
GTP-binding protein Di-Ras2

1

1

Small-scale

0.437

High

1141118

MYL6
Myosin light polypeptide 6

1

1

Small-scale

0.437

High

1152672

OTU6A
OTU domain-containing protein 6A

1

1

Small-scale

0.437

High

1207990

Q8C788
Sorting nexin

1

0

Small-scale

0.249

Low

1246898

RFIP1
Rab11 family-interacting protein 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024