Protein: RPC4
DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (C53) (DNA-directed RNA polymerase III 47 kDa polypeptide)

Gene: RPC4, RPC53
Organism: Saccharomyces cerevisiae S288C
Interactions: 73
UniProt ID: P25441

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005666 - RNA polymerase III complex
GO:0006383 - transcription by RNA polymerase III

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

674405

RPC5
DNA-directed RNA polymerase III subunit RPC5

7

0

Small-scale

0.915

High

647020

RPC2
DNA-directed RNA polymerase III subunit RPC2

8

0

Small-scale

0.914

High

459031

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

6

1

Small-scale

0.729

High

402195

RPC1
DNA-directed RNA polymerase III subunit RPC1

8

0

Small-scale

0.715

High

674404

RPC8
DNA-directed RNA polymerase III subunit RPC8

7

0

Small-scale

0.714

High

674394

RPC3
DNA-directed RNA polymerase III subunit RPC3

6

0

Small-scale

0.697

High

674401

RPC6
DNA-directed RNA polymerase III subunit RPC6

5

0

Small-scale

0.684

High

674420

RPC9
DNA-directed RNA polymerase III subunit RPC9

5

0

Small-scale

0.684

High

632129

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

0

Small-scale

0.655

High

609178

RPC7
DNA-directed RNA polymerase III subunit RPC7

3

0

High-throughput

0.634

High

632231

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

0

High-throughput

0.634

High

632308

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

0

High-throughput

0.634

High

674390

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

3

0

High-throughput

0.634

High

674402

TFC4
Transcription factor tau 131 kDa subunit

3

0

Small-scale

0.626

High

594217

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

1

Small-scale

0.584

High

674392

TF3B
Transcription factor IIIB 70 kDa subunit

2

1

High-throughput

0.584

High

645026

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

0

High-throughput

0.576

High

674428

RPC10
DNA-directed RNA polymerase III subunit RPC10

2

0

High-throughput

0.576

High

674438

SMT3
Ubiquitin-like protein SMT3

2

0

High-throughput

0.561

High

561424

TBP
TATA-box-binding protein

2

0

High-throughput

0.559

High

674415

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

543953

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

674432

RRP44
Exosome complex exonuclease DIS3

1

0

High-throughput

0.493

High

642332

MCK1
Protein kinase MCK1

1

0

Small-scale

0.480

High

674395

KNS1
Dual specificity protein kinase KNS1

1

0

Small-scale

0.480

High

380983

H2B1
Histone H2B.1

1

1

High-throughput

0.479

High

381419

H2B2
Histone H2B.2

1

1

High-throughput

0.479

High

674391

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

674399

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

Small-scale

0.460

High

381899

H4
Histone H4

1

0

High-throughput

0.458

High

448286

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

461017

MOD5
tRNA dimethylallyltransferase

1

0

Small-scale

0.458

High

488921

SWI6
Regulatory protein SWI6

1

0

High-throughput

0.458

High

668244

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

674393

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

674397

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

674400

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

674408

STS1
Tethering factor for nuclear proteasome STS1

1

0

High-throughput

0.458

High

674413

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.458

High

674414

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

674416

MAF1
Repressor of RNA polymerase III transcription MAF1

1

0

High-throughput

0.458

High

674417

BUD27
Bud site selection protein 27

1

0

High-throughput

0.458

High

674419

TFC5
Transcription factor TFIIIB component B''

1

0

High-throughput

0.458

High

674421

BUD17
Putative pyridoxal kinase BUD17

1

0

High-throughput

0.458

High

674422

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

674423

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

674424

H3
Histone H3

1

0

High-throughput

0.458

High

674425

SEN1
Helicase SEN1

1

0

Small-scale

0.458

High

674426

CTF4
DNA polymerase alpha-binding protein

1

0

High-throughput

0.458

High

674429

FUS2
Nuclear fusion protein FUS2

1

0

High-throughput

0.458

High

674430

PDR8
Transcription factor PDR8

1

0

High-throughput

0.458

High

674431

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

674434

SGO1
Shugoshin

1

0

High-throughput

0.458

High

674437

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

674439

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

674398

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

674412

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

526024

HSP72
Heat shock protein SSA2

1

0

High-throughput

0.426

High

570789

ABF1
ARS-binding factor 1

1

0

High-throughput

0.426

High

674435

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.426

High

674410

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.279

Low

674403

CASP
Protein CASP

1

0

High-throughput

0.269

Low

674406

BOI1
BEM1-interacting protein 1

1

0

High-throughput

0.261

Low

674418

LSB3
LAS seventeen-binding protein 3

1

0

High-throughput

0.261

Low

646635

VPS15
Serine/threonine-protein kinase VPS15

1

0

High-throughput

0.249

Low

674396

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

674407

KPR2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.249

Low

674409

SAK1
SNF1-activating kinase 1

1

0

High-throughput

0.249

Low

674427

NU100
Nucleoporin NUP100/NSP100

1

0

High-throughput

0.249

Low

674433

YO036
Uncharacterized protein YOL036W

1

0

High-throughput

0.249

Low

674436

UPPS
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.249

Low

574853

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.238

Low

674411

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025