Protein: B4DEF8
Large ribosomal subunit protein mL45 (39S ribosomal protein L45, mitochondrial)

Gene: B4DEF8
Organism: Homo sapiens
Interactions: 187
UniProt ID: B4DEF8

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005840 - ribosome
GO:1990904 - ribonucleoprotein complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

76029

RM04
Large ribosomal subunit protein uL4m

4

1

High-throughput

0.686

High

76056

RM39
Large ribosomal subunit protein mL39

4

1

High-throughput

0.686

High

75933

RS8
Small ribosomal subunit protein eS8

3

1

High-throughput

0.656

High

75952

RM28
Large ribosomal subunit protein bL28m

3

1

High-throughput

0.656

High

75996

RM50
Large ribosomal subunit protein mL50

3

1

High-throughput

0.656

High

76032

RM37
Large ribosomal subunit protein mL37

3

1

High-throughput

0.656

High

76046

RM47
Large ribosomal subunit protein uL29m

3

1

High-throughput

0.656

High

76047

RT30
Large ribosomal subunit protein mL65

3

1

High-throughput

0.656

High

75929

RM12
Large ribosomal subunit protein bL12m

2

1

High-throughput

0.611

High

75989

RM10
Large ribosomal subunit protein uL10m

2

1

High-throughput

0.611

High

75993

RM41
Large ribosomal subunit protein mL41

2

1

High-throughput

0.611

High

76059

RM35
Large ribosomal subunit protein bL35m

2

1

High-throughput

0.611

High

76070

RM42
Large ribosomal subunit protein mL42

2

1

High-throughput

0.611

High

75943

RL6
Large ribosomal subunit protein eL6

3

1

High-throughput

0.599

High

76035

RM18
Large ribosomal subunit protein uL18m

2

0

High-throughput

0.585

High

76061

RM27
Large ribosomal subunit protein bL27m

2

0

High-throughput

0.585

High

75949

GRSF1
G-rich sequence factor 1

2

1

High-throughput

0.584

High

76055

AKIP
Small ribosomal subunit protein mS38

2

1

High-throughput

0.584

High

75907

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.578

High

75891

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

75946

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

Small-scale

0.559

High

75958

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.559

High

75966

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

75913

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.536

High

75936

YBOX1
Y-box-binding protein 1

1

3

High-throughput

0.536

High

75962

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

2

High-throughput

0.536

High

75980

RBMS3
RNA-binding motif, single-stranded-interacting protein 3

1

2

High-throughput

0.536

High

76027

RM13
Large ribosomal subunit protein uL13m

1

1

High-throughput

0.536

High

75900

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

1

High-throughput

0.533

High

75892

RM33
Large ribosomal subunit protein bL33m

1

0

High-throughput

0.513

High

75942

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.513

High

75965

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

75968

RM51
Large ribosomal subunit protein mL51

1

0

High-throughput

0.513

High

75971

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.513

High

75979

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

75990

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.513

High

75998

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.513

High

75999

RM30
Large ribosomal subunit protein uL30m

1

0

High-throughput

0.513

High

76012

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

76013

RM53
Large ribosomal subunit protein mL53

1

0

High-throughput

0.513

High

76037

RM46
Large ribosomal subunit protein mL46

1

0

High-throughput

0.513

High

75940

SRSF3
Serine/arginine-rich splicing factor 3

1

1

High-throughput

0.489

High

75981

LN28B
Protein lin-28 homolog B

1

3

High-throughput

0.489

High

76067

YBOX2
Y-box-binding protein 2

1

3

High-throughput

0.489

High

75976

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.481

High

75893

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

75894

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

75921

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

75948

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

75959

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

High-throughput

0.479

High

75967

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

75977

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

75986

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

75997

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

76003

CELF1
CUGBP Elav-like family member 1

1

1

High-throughput

0.479

High

76004

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

76005

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

76006

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

76008

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

76016

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

76028

RM09
Large ribosomal subunit protein bL9m

1

1

High-throughput

0.479

High

76030

RM01
Large ribosomal subunit protein uL1m

1

1

High-throughput

0.479

High

76034

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

76038

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

76054

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

76057

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

76063

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

61352

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66074

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

75887

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

75896

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

75899

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

75901

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

75903

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

75904

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

75912

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

75914

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

75917

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

75919

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

75924

RM19
Large ribosomal subunit protein bL19m

1

0

High-throughput

0.458

High

75925

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

75931

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.458

High

75941

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

75944

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

75950

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

75954

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.458

High

75955

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

75957

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

75961

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

75963

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

75964

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.458

High

75969

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

75975

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

75978

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

75984

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

75985

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

75988

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.458

High

75992

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

76007

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

76009

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.458

High

76010

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

76011

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

76015

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

76017

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

76021

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

76022

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

76023

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

76024

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

76025

TR61B
tRNA

1

0

High-throughput

0.458

High

76026

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

76031

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

76033

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

76036

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

76040

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

76041

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

76042

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

76044

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.458

High

76048

NGRN
Neugrin

1

0

High-throughput

0.458

High

76050

RM17
Large ribosomal subunit protein bL17m

1

0

High-throughput

0.458

High

76051

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.458

High

76052

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

76053

RT18A
Large ribosomal subunit protein mL66

1

0

High-throughput

0.458

High

76060

RM15
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.458

High

76062

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

76068

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

76069

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

75911

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.439

High

75926

EMD
Emerin

1

1

High-throughput

0.439

High

76018

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.439

High

76045

PKHA3
Pleckstrin homology domain-containing family A member 3

1

1

High-throughput

0.439

High

66853

SPDE4
Speedy protein E4

1

1

High-throughput

0.437

High

75889

FOXS1
Forkhead box protein S1

1

5

High-throughput

0.437

High

75897

PDGFB
Platelet-derived growth factor subunit B

1

1

High-throughput

0.437

High

75906

EGLN
Endoglin

1

1

High-throughput

0.437

High

75915

KPCI
Protein kinase C iota type

1

2

High-throughput

0.437

High

75916

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.437

High

75920

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.437

High

75930

FGF8
Fibroblast growth factor 8

1

1

High-throughput

0.437

High

75945

KPCZ
Protein kinase C zeta type

1

2

High-throughput

0.437

High

75951

FOXL1
Forkhead box protein L1

1

5

High-throughput

0.437

High

75953

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.437

High

75956

CUL3
Cullin-3

1

1

High-throughput

0.437

High

75973

Z324B
Zinc finger protein 324B

1

1

High-throughput

0.437

High

75974

Q6ICH2
single-stranded DNA cytosine deaminase

1

1

High-throughput

0.437

High

75991

THOC4
THO complex subunit 4

1

1

High-throughput

0.437

High

76000

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

1

High-throughput

0.437

High

76001

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.437

High

76002

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.437

High

76019

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.437

High

76049

ZN331
Zinc finger protein 331

1

1

High-throughput

0.437

High

75934

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.426

High

75970

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

75888

NUP42
Nucleoporin NUP42

1

0

High-throughput

0.279

Low

75902

GLI4
Zinc finger protein GLI4

1

0

High-throughput

0.279

Low

75908

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.279

Low

75918

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.279

Low

75922

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.279

Low

75932

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.279

Low

75937

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

75939

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.279

Low

75947

SRSF4
Serine/arginine-rich splicing factor 4

1

0

High-throughput

0.279

Low

75983

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.279

Low

76014

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.279

Low

76020

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.279

Low

76058

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.279

Low

76066

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.279

Low

75890

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

75895

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

75898

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.249

Low

75905

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

75909

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

75910

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

75923

PRC2A
Protein PRRC2A

1

0

High-throughput

0.249

Low

75927

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

75928

ZN131
Zinc finger protein 131

1

0

High-throughput

0.249

Low

75938

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

75960

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

75972

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

75982

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

75987

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

High-throughput

0.249

Low

75994

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.249

Low

75995

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

76039

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.249

Low

76043

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

76064

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

76065

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.249

Low

75935

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025