Protein: IF5
Eukaryotic translation initiation factor 5 (eIF-5)

Gene: IF5, EIF5
Organism: Homo sapiens
Interactions: 170
UniProt ID: P55010

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005092 - GDP-dissociation inhibitor activity
GO:0005096 - GTPase activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

831972

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

7

High-throughput

0.691

High

835102

EIF1
Eukaryotic translation initiation factor 1

1

2

High-throughput

0.691

High

933294

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.691

High

933309

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

5

High-throughput

0.691

High

867770

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

1

Small-scale

0.653

High

933366

DUS12
Dual specificity protein phosphatase 12

3

0

High-throughput

0.646

High

166283

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

3

0

High-throughput

0.638

High

933353

CLPB
Mitochondrial disaggregase

2

4

High-throughput

0.628

High

627625

IF2B
Eukaryotic translation initiation factor 2 subunit 2

2

3

Small-scale

0.619

High

295123

EIF3G
Eukaryotic translation initiation factor 3 subunit G

2

4

Small-scale

0.611

High

933285

1433E
14-3-3 protein epsilon

2

1

Small-scale

0.611

High

345565

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

395757

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

933323

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

1

High-throughput

0.571

High

440464

FYN
Tyrosine-protein kinase Fyn

2

0

High-throughput

0.547

High

81688

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

3

High-throughput

0.536

High

187920

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

5

High-throughput

0.536

High

293428

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.536

High

303470

SRP72
Signal recognition particle subunit SRP72

1

2

High-throughput

0.536

High

426235

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

6

High-throughput

0.536

High

476611

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.536

High

550193

PABP1
Polyadenylate-binding protein 1

1

1

High-throughput

0.536

High

586598

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.536

High

625267

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.536

High

658054

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.536

High

785026

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

809545

RS19
Small ribosomal subunit protein eS19

1

3

High-throughput

0.536

High

824057

RL13A
Large ribosomal subunit protein uL13

1

3

High-throughput

0.536

High

840654

RS27
Small ribosomal subunit protein eS27

1

2

High-throughput

0.536

High

858853

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

866933

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

875598

PRC2A
Protein PRRC2A

1

1

High-throughput

0.536

High

890107

EI2BB
Translation initiation factor eIF2B subunit beta

1

7

High-throughput

0.536

High

933269

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

5

High-throughput

0.536

High

933272

IF4A1
Eukaryotic initiation factor 4A-I

1

2

High-throughput

0.536

High

933273

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.536

High

933276

ABCE1
ATP-binding cassette sub-family E member 1

1

3

High-throughput

0.536

High

933279

1433G
14-3-3 protein gamma

1

2

High-throughput

0.536

High

933280

RS7
Small ribosomal subunit protein eS7

1

3

High-throughput

0.536

High

933281

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.536

High

933282

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.536

High

933283

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

933286

RS14
Small ribosomal subunit protein uS11

1

3

High-throughput

0.536

High

933288

RS18
Small ribosomal subunit protein uS13

1

1

High-throughput

0.536

High

933289

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.536

High

933290

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.536

High

933291

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.536

High

933292

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.536

High

933295

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.536

High

933300

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

933306

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.536

High

933312

PABP4
Polyadenylate-binding protein 4

1

1

High-throughput

0.536

High

933313

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

4

High-throughput

0.536

High

933315

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

2

High-throughput

0.536

High

933317

EI2BA
Translation initiation factor eIF2B subunit alpha

1

7

High-throughput

0.536

High

933322

PRC2B
Protein PRRC2B

1

2

High-throughput

0.536

High

933329

RS27L
Ribosomal protein eS27-like

1

2

High-throughput

0.536

High

933330

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.536

High

933340

PSPC1
Paraspeckle component 1

1

3

High-throughput

0.536

High

933350

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

3

High-throughput

0.536

High

933357

EI2BG
Translation initiation factor eIF2B subunit gamma

1

5

High-throughput

0.536

High

933360

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

High-throughput

0.536

High

933365

EI2BD
Translation initiation factor eIF2B subunit delta

1

5

High-throughput

0.536

High

933369

CD2AP
CD2-associated protein

1

1

High-throughput

0.536

High

105642

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

415459

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

933320

PUM1
Pumilio homolog 1

1

0

High-throughput

0.518

High

933343

NEUG
Neurogranin

1

0

High-throughput

0.518

High

843417

HD
Huntingtin

1

2

High-throughput

0.515

High

187672

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.513

High

295306

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.513

High

389185

FINC
Fibronectin

1

0

High-throughput

0.513

High

428097

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.513

High

428334

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.513

High

445517

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

693618

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

770114

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.513

High

842278

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

859542

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.513

High

933271

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.513

High

933287

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.513

High

933296

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.513

High

933297

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.513

High

933298

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.513

High

933301

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.513

High

933302

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.513

High

933303

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

933304

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.513

High

933305

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.513

High

933318

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

933332

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.513

High

933361

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.513

High

933363

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

933367

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.513

High

933368

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

185559

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

421789

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

933347

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

933348

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

933274

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

172616

XPO1
Exportin-1

1

5

High-throughput

0.479

High

241203

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

247273

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.479

High

256810

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

411651

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

536831

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

605610

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

5

Small-scale

0.479

High

606499

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

686042

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.479

High

713976

PML
Protein PML

1

3

High-throughput

0.479

High

830416

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

933270

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.479

High

933277

RS3A
Small ribosomal subunit protein eS1

1

3

High-throughput

0.479

High

933284

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

933293

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

933299

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.479

High

933307

RL6
Large ribosomal subunit protein eL6

1

1

High-throughput

0.479

High

933308

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

933311

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

933314

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

933325

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

933326

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

933327

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

933328

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

933333

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

933336

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

933342

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

933344

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.479

High

933354

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.479

High

933355

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

933356

ANLN
Anillin

1

1

High-throughput

0.479

High

933358

BRWD1
Bromodomain and WD repeat-containing protein 1

1

3

High-throughput

0.479

High

933362

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

933364

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

136859

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

370174

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

385594

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

555976

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

642750

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

933275

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

933310

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.458

High

933316

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

933319

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

933334

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

933338

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

933341

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

933345

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

933346

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

933349

NECD
Necdin

1

0

High-throughput

0.458

High

94417

D6RAT0
Small ribosomal subunit protein eS1

1

3

High-throughput

0.445

High

429586

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

529422

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

563479

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

933335

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

933352

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

377472

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

588306

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

695035

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

767795

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

933278

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

933331

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

933339

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.437

High

171423

S27A2
Long-chain fatty acid transport protein 2

1

0

High-throughput

0.426

High

116385

H3BUK8
Large ribosomal subunit protein eL13

1

1

High-throughput

0.407

High

933321

R39L5
Putative ribosomal protein eL39-like 5

1

1

High-throughput

0.407

High

886677

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

933359

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.279

Low

933324

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

933337

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

933351

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025