Protein: URB2
Nucleolar pre-ribosomal-associated protein 2 (Unhealthy ribosome biogenesis protein 2)

Gene: URB2
Organism: Saccharomyces cerevisiae S288C
Interactions: 109
UniProt ID: P47108

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0006364 - rRNA processing
GO:0016072 - rRNA metabolic process
GO:0042254 - ribosome biogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

865404

DBP6
ATP-dependent RNA helicase DBP6

7

1

Small-scale

0.742

High

758228

URB1
Nucleolar pre-ribosomal-associated protein 1

9

0

Small-scale

0.717

High

865419

RSA3
Ribosome assembly protein 3

6

0

Small-scale

0.706

High

865426

NOP8
60S ribosome subunit biogenesis protein NOP8

4

0

Small-scale

0.648

High

865438

NOP58
Nucleolar protein 58

3

1

High-throughput

0.640

High

865431

YTM1
Ribosome biogenesis protein YTM1

3

0

High-throughput

0.618

High

844522

UTP10
U3 small nucleolar RNA-associated protein 10

3

0

High-throughput

0.613

High

781631

DBP7
ATP-dependent RNA helicase DBP7

2

2

Small-scale

0.584

High

865437

NOP56
Nucleolar protein 56

2

1

High-throughput

0.584

High

677215

SPB1
27S pre-rRNA

2

0

High-throughput

0.569

High

805062

RPF1
Ribosome production factor 1

2

0

High-throughput

0.569

High

570065

RL3
Large ribosomal subunit protein uL3

2

0

High-throughput

0.559

High

798257

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

804627

SSF1
Ribosome biogenesis protein SSF1

2

0

High-throughput

0.559

High

814340

NOC2
Nucleolar complex protein 2

2

0

High-throughput

0.559

High

865402

PESC
Pescadillo homolog

2

0

High-throughput

0.559

High

865422

DBP9
ATP-dependent RNA helicase DBP9

2

0

Small-scale

0.559

High

545415

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.536

High

433238

RL17A
Large ribosomal subunit protein uL22A

2

1

Small-scale

0.533

High

863842

RL17B
Large ribosomal subunit protein uL22B

2

1

Small-scale

0.533

High

722062

XPO1
Exportin-1

1

0

High-throughput

0.513

High

865425

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

677939

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.493

High

757503

NCBP1
Nuclear cap-binding protein complex subunit 1

1

0

High-throughput

0.493

High

779931

YRA2
RNA annealing protein YRA2

1

0

High-throughput

0.493

High

865410

IMA1
Importin subunit alpha

1

0

High-throughput

0.493

High

865421

IMB1
Importin subunit beta-1

1

0

High-throughput

0.493

High

865429

NCBP2
Nuclear cap-binding protein subunit 2

1

0

High-throughput

0.493

High

865432

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.493

High

678417

PWP2
Periodic tryptophan protein 2

1

1

High-throughput

0.479

High

682330

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.479

High

793494

MAK5
ATP-dependent RNA helicase MAK5

1

1

High-throughput

0.479

High

865403

YG5X
Putative methyltransferase YGR283C

1

1

High-throughput

0.479

High

865411

HAS1
ATP-dependent RNA helicase HAS1

1

1

High-throughput

0.479

High

865417

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.479

High

865420

UTP21
U3 small nucleolar RNA-associated protein 21

1

2

High-throughput

0.479

High

865423

NOC4
Nucleolar complex protein 4

1

1

High-throughput

0.479

High

865433

MAK21
Ribosome biogenesis protein MAK21

1

1

High-throughput

0.479

High

865435

UTP12
U3 small nucleolar RNA-associated protein 12

1

1

High-throughput

0.479

High

364620

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.458

High

419797

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

433725

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

435202

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

531796

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.458

High

534122

MAK16
Protein MAK16

1

0

High-throughput

0.458

High

585309

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

684772

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.458

High

707527

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

747931

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

751429

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

763589

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

791071

NOP4
Nucleolar protein 4

1

0

High-throughput

0.458

High

803885

CIC1
Proteasome-interacting protein CIC1

1

0

High-throughput

0.458

High

826629

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

827547

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

830135

NOP2
25S rRNA

1

0

Small-scale

0.458

High

864927

NOP9
Nucleolar protein 9

1

0

High-throughput

0.458

High

865397

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.458

High

865401

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.458

High

865405

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.458

High

865406

NOP13
Nucleolar protein 13

1

0

High-throughput

0.458

High

865407

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

865412

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

865413

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

865414

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

865415

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

865416

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.458

High

865418

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.458

High

865427

SGO1
Shugoshin

1

0

High-throughput

0.458

High

865430

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

865434

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

865436

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

865439

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

865440

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.458

High

524421

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

527064

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

727154

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

741891

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

819152

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

601078

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.437

High

712608

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.437

High

865398

RL37A
Large ribosomal subunit protein eL37A

1

1

Small-scale

0.437

High

865399

RL37B
Large ribosomal subunit protein eL37B

1

1

Small-scale

0.437

High

597195

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

804265

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

752456

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

410216

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

503128

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

513096

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

558791

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

579669

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

747456

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

748456

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

753458

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

778412

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

800663

KPR2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.249

Low

802260

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

807824

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

812453

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

815417

RS26B
Small ribosomal subunit protein eS26B

1

0

High-throughput

0.249

Low

826348

INP51
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51

1

0

High-throughput

0.249

Low

865400

ART5
Arrestin-related trafficking adapter 5

1

0

High-throughput

0.249

Low

865408

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

865409

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

865428

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

453671

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

863631

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

865424

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025