Protein: MAK16
Protein MAK16 (Maintenance of killer protein 16)

Gene: MAK16
Organism: Saccharomyces cerevisiae S288C
Interactions: 103
UniProt ID: P10962

Gene Ontology (top 5):
GO:0000460 - maturation of 5.8S rRNA
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 - maturation of LSU-rRNA
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534107

RPF1
Ribosome production factor 1

4

2

High-throughput

0.881

High

534100

RPF2
Ribosome biogenesis protein RPF2

3

2

Small-scale

0.817

High

534096

RRP1
Ribosomal RNA-processing protein 1

2

3

Small-scale

0.754

High

534106

SSF1
Ribosome biogenesis protein SSF1

2

3

Small-scale

0.754

High

534126

PESC
Pescadillo homolog

5

1

Small-scale

0.709

High

534111

NOC2
Nucleolar complex protein 2

4

1

Small-scale

0.680

High

534117

RLP7
Ribosome biogenesis protein RLP7

4

2

Small-scale

0.680

High

534125

NSA1
Ribosome biogenesis protein NSA1

4

2

Small-scale

0.676

High

534146

DBP9
ATP-dependent RNA helicase DBP9

3

1

High-throughput

0.670

High

534151

NOC3
Nucleolar complex-associated protein 3

3

3

High-throughput

0.646

High

534165

DBP10
ATP-dependent RNA helicase DBP10

3

3

High-throughput

0.640

High

534154

BRX1
Ribosome biogenesis protein BRX1

1

12

High-throughput

0.618

High

534163

SSF2
Ribosome biogenesis protein SSF2

1

3

High-throughput

0.618

High

534095

URB1
Nucleolar pre-ribosomal-associated protein 1

2

0

High-throughput

0.607

High

534081

MAK11
Protein MAK11

2

2

Small-scale

0.584

High

534085

SPB4
ATP-dependent rRNA helicase SPB4

2

3

High-throughput

0.584

High

534105

CIC1
Proteasome-interacting protein CIC1

2

2

High-throughput

0.584

High

534118

NOP2
25S rRNA

2

2

Small-scale

0.584

High

534130

NOP15
Ribosome biogenesis protein 15

2

2

High-throughput

0.584

High

534135

HAS1
ATP-dependent RNA helicase HAS1

2

5

High-throughput

0.584

High

534152

RLP24
Ribosome biogenesis protein RLP24

2

2

Small-scale

0.584

High

534164

MAK21
Ribosome biogenesis protein MAK21

2

5

High-throughput

0.584

High

534139

PUF6
Pumilio homology domain family member 6

2

1

Small-scale

0.571

High

534104

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

433394

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

512206

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

534079

MAK16
Protein MAK16

1

1

High-throughput

0.479

High

534083

SPB1
27S pre-rRNA

1

2

High-throughput

0.479

High

534084

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

534090

DRS1
ATP-dependent RNA helicase DRS1

1

4

High-throughput

0.479

High

534093

MRT4
Ribosome assembly factor MRT4

1

1

High-throughput

0.479

High

534098

EBP2
rRNA-processing protein EBP2

1

2

High-throughput

0.479

High

534101

NOP4
Nucleolar protein 4

1

1

High-throughput

0.479

High

534102

MAK5
ATP-dependent RNA helicase MAK5

1

5

High-throughput

0.479

High

534108

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.479

High

534113

NUG1
Nuclear GTP-binding protein NUG1

1

2

High-throughput

0.479

High

534114

NSA2
Ribosome biogenesis protein NSA2

1

1

High-throughput

0.479

High

534121

MTR4
ATP-dependent RNA helicase DOB1

1

1

Small-scale

0.479

High

534128

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.479

High

534129

NOP13
Nucleolar protein 13

1

1

High-throughput

0.479

High

534134

NOG1
Nucleolar GTP-binding protein 1

1

2

High-throughput

0.479

High

534141

ERB1
Ribosome biogenesis protein ERB1

1

2

High-throughput

0.479

High

534142

RRP5
rRNA biogenesis protein RRP5

1

1

High-throughput

0.479

High

534144

FKBP4
FK506-binding protein 4

1

1

High-throughput

0.479

High

534145

JIP5
WD repeat-containing protein JIP5

1

2

High-throughput

0.479

High

534149

NOC4
Nucleolar complex protein 4

1

5

High-throughput

0.479

High

534153

NOP12
Nucleolar protein 12

1

2

High-throughput

0.479

High

534159

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.479

High

534160

NIP7
60S ribosome subunit biogenesis protein NIP7

1

1

High-throughput

0.479

High

534161

YTM1
Ribosome biogenesis protein YTM1

1

3

High-throughput

0.479

High

534167

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

149537

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

409886

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

435719

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

441653

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

534082

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

534086

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

534099

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

534103

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

534112

NOP16
Nucleolar protein 16

1

0

High-throughput

0.458

High

534119

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

534120

LOC1
60S ribosomal subunit assembly/export protein LOC1

1

0

High-throughput

0.458

High

534122

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.458

High

534136

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

534137

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

534140

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

534148

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

534162

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

534166

NOP58
Nucleolar protein 58

1

0

High-throughput

0.458

High

436298

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.437

High

503991

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

534091

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

534094

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

534132

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.437

High

534133

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

534116

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

534088

XPO1
Exportin-1

1

0

High-throughput

0.279

Low

534127

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.279

Low

534155

DNLI4
DNA ligase 4

1

0

High-throughput

0.279

Low

534157

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.279

Low

380930

H2B1
Histone H2B.1

1

0

High-throughput

0.249

Low

434748

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

502793

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

512766

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514403

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

534080

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

534087

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

534089

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

534092

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

534097

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

534109

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low

534110

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

534115

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.249

Low

534124

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

534131

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.249

Low

534138

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

534143

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

534147

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

534150

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

534156

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

534158

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

534123

VPS55
Vacuolar protein sorting-associated protein 55

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025