Protein: MRD1
Multiple RNA-binding domain-containing protein 1

Gene: MRD1
Organism: Saccharomyces cerevisiae S288C
Interactions: 120
UniProt ID: Q06106

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

435370

RS3
Small ribosomal subunit protein uS3

2

3

High-throughput

0.789

High

1053613

NOP12
Nucleolar protein 12

1

15

Small-scale

0.691

High

864963

NOP9
Nucleolar protein 9

4

2

Small-scale

0.683

High

677568

KRR1
KRR1 small subunit processome component

3

4

Small-scale

0.656

High

798313

ENP1
Essential nuclear protein 1

3

2

High-throughput

0.656

High

844616

UTP10
U3 small nucleolar RNA-associated protein 10

3

2

Small-scale

0.656

High

655517

RS3A2
Small ribosomal subunit protein eS1B

2

5

Small-scale

0.628

High

806575

UTP9
U3 small nucleolar RNA-associated protein 9

2

1

Small-scale

0.628

High

918826

UTP22
U3 small nucleolar RNA-associated protein 22

2

1

Small-scale

0.628

High

817633

UTP7
U3 small nucleolar RNA-associated protein 7

2

3

High-throughput

0.621

High

644992

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

3

High-throughput

0.618

High

692626

NSR1
Nuclear localization sequence-binding protein

1

18

High-throughput

0.618

High

1053616

NCBP2
Nuclear cap-binding protein subunit 2

1

15

High-throughput

0.618

High

512661

RS6A
Small ribosomal subunit protein eS6A

2

4

Small-scale

0.611

High

678462

PWP2
Periodic tryptophan protein 2

2

5

Small-scale

0.611

High

747584

RSSA1
Small ribosomal subunit protein uS2A

2

3

High-throughput

0.611

High

1053512

UTP21
U3 small nucleolar RNA-associated protein 21

2

6

Small-scale

0.611

High

1053617

BMS1
Ribosome biogenesis protein BMS1

2

3

Small-scale

0.611

High

1053624

NOP56
Nucleolar protein 56

2

5

Small-scale

0.611

High

393354

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.608

High

531895

RL4A
Large ribosomal subunit protein uL4A

2

3

Small-scale

0.601

High

546331

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.601

High

1036411

UTP6
U3 small nucleolar RNA-associated protein 6

2

0

Small-scale

0.585

High

432705

RL7A
Large ribosomal subunit protein uL30A

1

6

High-throughput

0.575

High

1053610

UTP4
U3 small nucleolar RNA-associated protein 4

2

5

Small-scale

0.571

High

410344

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.553

High

438165

NOT2
General negative regulator of transcription subunit 2

1

3

High-throughput

0.536

High

512155

RS4A
Small ribosomal subunit protein eS4A

1

1

Small-scale

0.536

High

570147

RL3
Large ribosomal subunit protein uL3

1

2

Small-scale

0.536

High

585379

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

Small-scale

0.536

High

754335

DCA13
Protein SOF1

1

2

Small-scale

0.536

High

779161

DHR2
Probable ATP-dependent RNA helicase DHR2

1

4

Small-scale

0.536

High

852605

ROK1
ATP-dependent RNA helicase ROK1

1

6

Small-scale

0.536

High

865174

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

1

Small-scale

0.536

High

917482

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

Small-scale

0.536

High

1039853

UTP17
NET1-associated nuclear protein 1

1

4

Small-scale

0.536

High

1043283

HAS1
ATP-dependent RNA helicase HAS1

1

10

Small-scale

0.536

High

1046252

UTP15
U3 small nucleolar RNA-associated protein 15

1

3

Small-scale

0.536

High

1050164

RRP5
rRNA biogenesis protein RRP5

1

6

Small-scale

0.536

High

1053109

UTP13
U3 small nucleolar RNA-associated protein 13

1

11

Small-scale

0.536

High

1053620

MAK21
Ribosome biogenesis protein MAK21

1

6

Small-scale

0.536

High

1053621

UTP12
U3 small nucleolar RNA-associated protein 12

1

8

Small-scale

0.536

High

919173

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

Small-scale

0.513

High

1053608

PIN3
[PSI+] inducibility protein 3

1

4

High-throughput

0.508

High

792955

ANM1
Protein arginine N-methyltransferase 1

1

7

Small-scale

0.501

High

861048

RS10B
Small ribosomal subunit protein eS10B

1

4

High-throughput

0.489

High

149961

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

436178

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.479

High

436521

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.479

High

442117

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

513225

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

514841

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

515327

RL35A
Large ribosomal subunit protein uL29A

1

3

High-throughput

0.479

High

558869

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

580090

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

594574

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

671138

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

674842

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

689140

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.479

High

689668

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

708223

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

735165

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

738261

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

4

High-throughput

0.479

High

753592

RS3A1
Small ribosomal subunit protein eS1A

1

5

High-throughput

0.479

High

778537

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

792254

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.479

High

802392

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

824794

MLP2
Protein MLP2

1

8

High-throughput

0.479

High

826845

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

874535

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

924190

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.479

High

925061

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

925198

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

1033572

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

1038753

XRN2
5'-3' exoribonuclease 2

1

5

High-throughput

0.479

High

1046792

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.479

High

1051610

HRQ1
ATP-dependent helicase HRQ1

1

10

Small-scale

0.479

High

1053607

ESF1
Pre-rRNA-processing protein ESF1

1

2

High-throughput

0.479

High

1053609

NOC4
Nucleolar complex protein 4

1

6

High-throughput

0.479

High

1053614

SGO1
Shugoshin

1

2

High-throughput

0.479

High

1053618

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

1053619

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

1053625

NOP58
Nucleolar protein 58

1

5

High-throughput

0.479

High

1053626

EFG1P
rRNA-processing protein EFG1

1

1

High-throughput

0.479

High

1053627

NOP14
Nucleolar complex protein 14

1

1

Small-scale

0.479

High

672950

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

673231

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

824948

TM108
Protein TMA108

1

0

High-throughput

0.458

High

919778

YG5X
Putative methyltransferase YGR283C

1

0

High-throughput

0.458

High

1046474

BUD22
Bud site selection protein 22

1

0

High-throughput

0.458

High

1053611

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

1053612

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

1053622

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.458

High

394917

EF1A
Elongation factor 1-alpha

1

9

High-throughput

0.445

High

427450

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.445

High

525192

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

527711

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

684848

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.445

High

727318

HS104
Heat shock protein 104

1

4

High-throughput

0.445

High

742428

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

804467

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.445

High

924737

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.445

High

1053623

UTP23
rRNA-processing protein UTP23

1

1

High-throughput

0.445

High

383899

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

433855

RL26A
Large ribosomal subunit protein uL24A

1

5

High-throughput

0.437

High

455269

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.437

High

503249

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504420

RL31A
Large ribosomal subunit protein eL31A

1

4

High-throughput

0.437

High

514192

RS16B
Small ribosomal subunit protein uS9B

1

4

High-throughput

0.437

High

812671

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

1025042

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.437

High

1053615

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

453797

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

486318

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

836901

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

712673

RL8B
Large ribosomal subunit protein eL8B

1

4

High-throughput

0.407

High

755176

GCN1
eIF-2-alpha kinase activator GCN1

1

7

High-throughput

0.407

High

797664

GDT1
Divalent cation/proton antiporter GDT1

1

0

High-throughput

0.269

Low

511297

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

811041

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025