Protein: TPSN
Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein)

Gene: TPSN, TAPBP
Organism: Homo sapiens
Interactions: 79
UniProt ID: O15533

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002398 - MHC class Ib protein complex assembly
GO:0002502 - peptide antigen assembly with MHC class I protein complex
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

193700

HFE
Hereditary hemochromatosis protein

2

15

High-throughput

0.776

High

193695

TAP1
Antigen peptide transporter 1

6

6

Small-scale

0.732

High

193662

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

20

High-throughput

0.691

High

193663

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

20

High-throughput

0.691

High

193667

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

20

High-throughput

0.691

High

193670

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

13

High-throughput

0.691

High

193679

DMB
HLA class II histocompatibility antigen, DM beta chain

1

19

High-throughput

0.691

High

193730

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.691

High

193678

CALR
Calreticulin

3

6

Small-scale

0.650

High

193696

TAP2
Antigen peptide transporter 2

2

6

Small-scale

0.624

High

193674

PRG2
Bone marrow proteoglycan

1

2

High-throughput

0.618

High

193685

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

3

High-throughput

0.618

High

193688

GLR
Glucagon receptor

1

3

High-throughput

0.618

High

193720

KLK15
Kallikrein-15

1

5

High-throughput

0.618

High

193727

BTNL2
Butyrophilin-like protein 2

1

10

High-throughput

0.618

High

193666

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

13

Small-scale

0.618

High

193692

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

20

Small-scale

0.618

High

193682

PDIA3
Protein disulfide-isomerase A3

2

1

Small-scale

0.611

High

193707

LYZL2
Lysozyme-like protein 2

1

0

High-throughput

0.578

High

193661

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

13

High-throughput

0.575

High

193680

5HT2C
5-hydroxytryptamine receptor 2C

2

1

High-throughput

0.574

High

193706

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.553

High

193673

CFTR
Cystic fibrosis transmembrane conductance regulator

2

3

High-throughput

0.552

High

193676

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.546

High

193672

PSPC
Surfactant protein C

1

1

High-throughput

0.536

High

193719

CHST8
Carbohydrate sulfotransferase 8

1

2

High-throughput

0.536

High

193723

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.536

High

193728

FBX2
F-box only protein 2

1

4

High-throughput

0.536

High

193664

ESR1
Estrogen receptor

2

3

High-throughput

0.521

High

193689

S6A12
Sodium- and chloride-dependent betaine transporter

1

3

High-throughput

0.514

High

193690

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

3

High-throughput

0.514

High

193724

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

3

High-throughput

0.514

High

193677

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.513

High

193729

PILRB
Paired immunoglobulin-like type 2 receptor beta

1

0

High-throughput

0.513

High

64333

CDHR4
Cadherin-related family member 4

1

3

High-throughput

0.489

High

193659

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.489

High

193675

IDS
Iduronate 2-sulfatase

1

3

High-throughput

0.489

High

193694

IL5RA
Interleukin-5 receptor subunit alpha

1

8

High-throughput

0.489

High

193701

GXLT1
Glucoside xylosyltransferase 1

1

1

High-throughput

0.489

High

193704

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.489

High

193713

LPAR1
Lysophosphatidic acid receptor 1

1

2

High-throughput

0.489

High

193716

T106A
Transmembrane protein 106A

1

5

High-throughput

0.489

High

193717

ASIC4
Acid-sensing ion channel 4

1

2

High-throughput

0.489

High

193721

LPAR2
Lysophosphatidic acid receptor 2

1

3

High-throughput

0.489

High

193669

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

193705

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

193709

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

High-throughput

0.479

High

193656

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

193691

COPB
Coatomer subunit beta

1

0

Small-scale

0.458

High

193731

COPG1
Coatomer subunit gamma-1

1

0

Small-scale

0.458

High

170563

CLGN
Calmegin

1

6

High-throughput

0.445

High

193665

VTNC
Vitronectin

1

1

High-throughput

0.445

High

193655

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

193658

PRDM1
PR domain zinc finger protein 1

1

1

Small-scale

0.437

High

193668

ISG15
Ubiquitin-like protein ISG15

1

1

High-throughput

0.437

High

193671

IRF1
Interferon regulatory factor 1

1

3

Small-scale

0.437

High

193697

TF65
Transcription factor p65

1

1

Small-scale

0.437

High

193699

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.437

High

193702

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.437

High

193711

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

193714

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

193725

T106B
Transmembrane protein 106B

1

5

High-throughput

0.437

High

193660

MOT3
Monocarboxylate transporter 3

1

2

High-throughput

0.407

High

193681

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

193683

CTR1
High affinity cationic amino acid transporter 1

1

4

High-throughput

0.407

High

193686

S19A1
Reduced folate transporter

1

2

High-throughput

0.407

High

193698

MFS10
Major facilitator superfamily domain-containing protein 10

1

7

High-throughput

0.407

High

193710

AGRG5
Adhesion G-protein coupled receptor G5

1

5

High-throughput

0.407

High

193712

MFSD8
Major facilitator superfamily domain-containing protein 8

1

5

High-throughput

0.407

High

193718

S1PR3
Sphingosine 1-phosphate receptor 3

1

2

High-throughput

0.407

High

193684

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

0

High-throughput

0.279

Low

193715

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

193726

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

193693

H4
Histone H4

1

0

High-throughput

0.249

Low

193708

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.249

Low

193657

ADCY9
Adenylate cyclase type 9

1

0

High-throughput

0.232

Low

193687

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low

193703

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

193722

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025