Protein: PUR4
Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase)

Gene: PUR4, PFAS
Organism: Homo sapiens
Interactions: 110
UniProt ID: O15067

Gene Ontology (top 5):
GO:0004642 - phosphoribosylformylglycinamidine synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006164 - purine nucleotide biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

176704

DNJC7
DnaJ homolog subfamily C member 7

2

0

High-throughput

0.585

High

176679

A16L1
Autophagy-related protein 16-1

2

1

High-throughput

0.571

High

176627

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

176642

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.559

High

176700

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

176672

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.513

High

176723

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

0

High-throughput

0.513

High

176721

DUX4
Double homeobox protein 4

1

0

High-throughput

0.494

High

176643

EPB41
Protein 4.1

1

0

High-throughput

0.493

High

176645

TFE3
Transcription factor E3

1

0

High-throughput

0.493

High

176648

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.493

High

176651

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

176731

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.493

High

176641

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

176626

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

176630

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

1

High-throughput

0.479

High

176653

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.479

High

176654

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

176691

SSH3
Protein phosphatase Slingshot homolog 3

1

1

High-throughput

0.479

High

176696

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

176707

DUS26
Dual specificity protein phosphatase 26

1

1

High-throughput

0.479

High

176712

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.479

High

176720

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.470

High

122888

SGK1
Serine/threonine-protein kinase Sgk1

1

0

High-throughput

0.458

High

176629

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

High-throughput

0.458

High

176632

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

176634

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

176635

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

176637

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

176638

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

176639

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

176647

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.458

High

176652

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

176656

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

176658

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.458

High

176660

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

176661

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

176662

CCNA1
Cyclin-A1

1

0

High-throughput

0.458

High

176664

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

176666

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

176669

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

176670

MTM1
Myotubularin

1

0

High-throughput

0.458

High

176671

CUL3
Cullin-3

1

0

High-throughput

0.458

High

176673

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

176674

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

176675

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

176676

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

176677

CCDC6
Coiled-coil domain-containing protein 6

1

0

High-throughput

0.458

High

176678

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

176680

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

176681

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

176684

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

176685

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

176689

WDTC1
WD and tetratricopeptide repeats protein 1

1

0

High-throughput

0.458

High

176693

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

176694

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

176697

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

176698

OPTN
Optineurin

1

0

High-throughput

0.458

High

176702

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

176705

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

176706

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

176709

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

176711

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

High-throughput

0.458

High

176713

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

176714

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

176716

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

176719

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

176722

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

176724

FBW1B
F-box/WD repeat-containing protein 11

1

0

High-throughput

0.458

High

176727

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

176657

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

176665

TLE2
Transducin-like enhancer protein 2

1

1

High-throughput

0.437

High

176667

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

176718

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

176726

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.437

High

142237

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.426

High

176633

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

176636

PRIO
Major prion protein

1

0

High-throughput

0.426

High

176646

CAP7
Azurocidin

1

0

High-throughput

0.426

High

176655

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

176659

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

0

High-throughput

0.426

High

176686

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

176695

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

176708

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

176715

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

176717

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

176728

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

176649

CD27
CD27 antigen

1

1

High-throughput

0.407

High

176701

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.407

High

104855

APRIO
Alternative prion protein

3

0

High-throughput

0.334

High

176628

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.279

Low

176699

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

176703

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.279

Low

176725

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.279

Low

176640

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.249

Low

176644

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

176650

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

176682

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

176683

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

176687

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

176688

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

176692

DCA11
DDB1- and CUL4-associated factor 11

1

0

High-throughput

0.249

Low

176730

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

176631

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

176663

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.232

Low

176668

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

176690

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.232

Low

176710

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low

176729

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.232

Low

176732

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025