Protein: DIM1
Dimethyladenosine transferase (EC 2.1.1.183) (18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (18S rRNA dimethylase) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase)

Gene: DIM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 108
UniProt ID: P41819

Gene Ontology (top 5):
GO:0000154 - rRNA modification
GO:0000179 - rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

820371

RIO2
Serine/threonine-protein kinase RIO2

13

2

Small-scale

0.757

High

798243

ENP1
Essential nuclear protein 1

11

2

Small-scale

0.754

High

836205

TSR1
Ribosome biogenesis protein TSR1

8

1

Small-scale

0.747

High

149818

RS9A
Small ribosomal subunit protein uS4A

2

0

High-throughput

0.699

High

836201

DHR1
Probable ATP-dependent RNA helicase DHR1

4

1

Small-scale

0.676

High

836221

RRP12
Ribosomal RNA-processing protein 12

5

0

Small-scale

0.676

High

836209

NOB1
20S-pre-rRNA D-site endonuclease NOB1

5

0

Small-scale

0.673

High

836204

NOC4
Nucleolar complex protein 4

5

0

Small-scale

0.672

High

756683

LTV1
Protein LTV1

5

0

Small-scale

0.666

High

836223

PNO1
Pre-rRNA-processing protein PNO1

4

0

Small-scale

0.644

High

836202

UTP14
U3 small nucleolar RNA-associated protein 14

3

1

Small-scale

0.640

High

709407

HRR25
Casein kinase I homolog HRR25

3

0

Small-scale

0.638

High

836189

UTP22
U3 small nucleolar RNA-associated protein 22

3

0

High-throughput

0.634

High

678408

PWP2
Periodic tryptophan protein 2

3

0

High-throughput

0.628

High

836203

RRP9
Ribosomal RNA-processing protein 9

2

4

High-throughput

0.611

High

836188

SLX9
Ribosome biogenesis protein SLX9

3

0

Small-scale

0.606

High

836213

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

2

0

Small-scale

0.592

High

435161

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.586

High

806532

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

High-throughput

0.585

High

677450

KRR1
KRR1 small subunit processome component

2

1

High-throughput

0.584

High

512496

RS6A
Small ribosomal subunit protein eS6A

2

1

High-throughput

0.571

High

513066

RS8A
Small ribosomal subunit protein eS8A

2

1

High-throughput

0.571

High

674681

RS2
Small ribosomal subunit protein uS5

2

1

High-throughput

0.571

High

836192

CSL4
Exosome complex component CSL4

2

0

High-throughput

0.559

High

836207

RCL1
rRNA processing protein RCL1

2

0

Small-scale

0.559

High

436021

RS13
Small ribosomal subunit protein uS15

2

0

High-throughput

0.547

High

441969

RS14A
Small ribosomal subunit protein uS11A

2

0

High-throughput

0.547

High

689516

RS7A
Small ribosomal subunit protein eS7A

2

0

High-throughput

0.547

High

753429

RS3A1
Small ribosomal subunit protein eS1A

2

0

High-throughput

0.547

High

778381

RS27A
Small ribosomal subunit protein eS27A

2

0

High-throughput

0.547

High

678241

BUD23
18S rRNA

1

0

High-throughput

0.546

High

722021

XPO1
Exportin-1

1

3

High-throughput

0.536

High

503101

RS22A
Small ribosomal subunit protein uS8A

2

1

High-throughput

0.521

High

796088

IMB2
Importin subunit beta-2

1

0

High-throughput

0.513

High

704614

SBA1
Co-chaperone protein SBA1

1

0

Small-scale

0.504

High

602515

PHO85
Cyclin-dependent protein kinase PHO85

1

1

High-throughput

0.501

High

364592

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

410189

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

433698

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

455115

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

792100

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

802228

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

836181

RRP41
Exosome complex component SKI6

1

1

High-throughput

0.479

High

836186

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

836190

RRP46
Exosome complex component RRP46

1

2

High-throughput

0.479

High

836199

UTP17
NET1-associated nuclear protein 1

1

2

High-throughput

0.479

High

836200

UTP5
U3 small nucleolar RNA-associated protein 5

1

1

High-throughput

0.479

High

836211

BMS1
Ribosome biogenesis protein BMS1

1

1

Small-scale

0.479

High

836218

RRP42
Exosome complex component RRP42

1

1

High-throughput

0.479

High

836219

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

836220

NOP58
Nucleolar protein 58

1

1

High-throughput

0.479

High

751860

SLA2
Protein SLA2

1

3

High-throughput

0.464

High

436445

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

514684

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

558768

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

670834

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

672901

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

673191

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

735024

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

747426

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

804720

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.458

High

804933

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

815147

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

818312

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

823344

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

825529

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

836180

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

836182

MTR4
ATP-dependent RNA helicase DOB1

1

0

High-throughput

0.458

High

836183

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

836184

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

0

Small-scale

0.458

High

836185

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

836191

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.458

High

836193

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

836194

NOP15
Ribosome biogenesis protein 15

1

0

High-throughput

0.458

High

836195

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

836196

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

Small-scale

0.458

High

836198

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

836206

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

836208

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

836210

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

836212

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

836214

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

836215

SAS10
Something about silencing protein 10

1

0

Small-scale

0.458

High

836216

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

836222

NOP14
Nucleolar complex protein 14

1

0

Small-scale

0.458

High

513877

RS11B
Small ribosomal subunit protein uS17B

1

1

High-throughput

0.445

High

545241

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

592317

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

819019

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

504266

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

694567

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.437

High

365081

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

394654

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

453650

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

511674

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.426

High

511812

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.426

High

512097

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.426

High

597488

EF3A
Elongation factor 3A

1

0

High-throughput

0.279

Low

383753

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

561487

TBP
TATA-box-binding protein

1

0

High-throughput

0.249

Low

707378

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

795048

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

812398

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

826580

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

836187

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

836197

H3
Histone H3

1

0

High-throughput

0.249

Low

836217

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.249

Low

511940

RS30A
Small ribosomal subunit protein eS30A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025