Protein: CSL4
Exosome complex component CSL4 (CEP1 synthetic lethal protein 4)

Gene: CSL4
Organism: Saccharomyces cerevisiae S288C
Interactions: 108
UniProt ID: P53859

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 - nuclear-transcribed mRNA catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

918880

RRP46
Exosome complex component RRP46

15

11

Small-scale

0.983

High

863121

RRP41
Exosome complex component SKI6

12

15

Small-scale

0.979

High

923984

RRP45
Exosome complex component RRP45

12

12

Small-scale

0.978

High

804734

RRP4
Exosome complex component RRP4

9

6

Small-scale

0.970

High

923994

RRP40
Exosome complex component RRP40

7

2

Small-scale

0.956

High

871112

MTR3
Exosome complex component MTR3

11

0

Small-scale

0.926

High

672927

RRP43
Exosome complex component RRP43

10

0

Small-scale

0.923

High

923979

DHR1
Probable ATP-dependent RNA helicase DHR1

3

0

High-throughput

0.784

High

923993

RRP44
Exosome complex exonuclease DIS3

13

4

Small-scale

0.760

High

924000

RRP6
Exosome complex exonuclease RRP6

14

2

Small-scale

0.760

High

923995

SKI7
Superkiller protein 7

10

1

Small-scale

0.756

High

864490

MTR4
ATP-dependent RNA helicase DOB1

2

3

High-throughput

0.754

High

924003

RRP42
Exosome complex component RRP42

10

12

Small-scale

0.754

High

804945

LRP1
Exosome complex protein LRP1

6

0

Small-scale

0.691

High

922945

MPP6
M-phase phosphoprotein 6 homolog

5

0

Small-scale

0.685

High

798281

ENP1
Essential nuclear protein 1

4

0

High-throughput

0.648

High

678435

PWP2
Periodic tryptophan protein 2

3

3

Small-scale

0.640

High

923978

UTP5
U3 small nucleolar RNA-associated protein 5

3

2

Small-scale

0.640

High

923985

UTP13
U3 small nucleolar RNA-associated protein 13

3

4

Small-scale

0.640

High

923991

UTP4
U3 small nucleolar RNA-associated protein 4

3

2

Small-scale

0.640

High

763846

SKI2
Antiviral helicase SKI2

1

3

High-throughput

0.618

High

844563

UTP10
U3 small nucleolar RNA-associated protein 10

3

0

High-throughput

0.613

High

923981

UTP14
U3 small nucleolar RNA-associated protein 14

3

0

High-throughput

0.613

High

923989

NOC4
Nucleolar complex protein 4

3

0

High-throughput

0.613

High

827055

YIV5
Uncharacterized oxidoreductase YIR035C

2

0

High-throughput

0.595

High

852586

ROK1
ATP-dependent RNA helicase ROK1

1

0

High-throughput

0.586

High

923970

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.586

High

754314

DCA13
Protein SOF1

2

2

High-throughput

0.584

High

817606

UTP7
U3 small nucleolar RNA-associated protein 7

2

1

High-throughput

0.584

High

923976

UTP17
NET1-associated nuclear protein 1

2

4

High-throughput

0.584

High

923980

UTP15
U3 small nucleolar RNA-associated protein 15

2

2

High-throughput

0.584

High

923986

UTP21
U3 small nucleolar RNA-associated protein 21

2

4

High-throughput

0.584

High

923988

RRP9
Ribosomal RNA-processing protein 9

2

3

High-throughput

0.584

High

924002

UTP12
U3 small nucleolar RNA-associated protein 12

2

4

High-throughput

0.584

High

924004

NOP56
Nucleolar protein 56

2

1

High-throughput

0.584

High

924005

NOP58
Nucleolar protein 58

2

1

High-throughput

0.584

High

923975

IMA1
Importin subunit alpha

2

0

High-throughput

0.563

High

673211

RRP7
Ribosomal RNA-processing protein 7

2

0

High-throughput

0.559

High

677509

KRR1
KRR1 small subunit processome component

2

0

High-throughput

0.559

High

689585

RS7A
Small ribosomal subunit protein eS7A

2

0

Small-scale

0.559

High

758396

UTP11
U3 small nucleolar RNA-associated protein 11

2

0

High-throughput

0.559

High

763604

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

High-throughput

0.559

High

806553

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

High-throughput

0.559

High

823369

UTP18
U3 small nucleolar RNA-associated protein 18

2

0

High-throughput

0.559

High

836192

DIM1
Dimethyladenosine transferase

2

0

High-throughput

0.559

High

865150

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

0

High-throughput

0.559

High

918793

UTP22
U3 small nucleolar RNA-associated protein 22

2

0

High-throughput

0.559

High

919152

UTP8
U3 small nucleolar RNA-associated protein 8

2

0

High-throughput

0.559

High

923973

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

2

0

High-throughput

0.559

High

923974

UTP6
U3 small nucleolar RNA-associated protein 6

2

0

High-throughput

0.559

High

923982

RRP5
rRNA biogenesis protein RRP5

2

0

High-throughput

0.559

High

923983

FCF1
rRNA-processing protein FCF1

2

0

High-throughput

0.559

High

923987

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

2

0

High-throughput

0.559

High

923992

RCL1
rRNA processing protein RCL1

2

0

High-throughput

0.559

High

923996

UTP16
U3 small nucleolar RNA-associated protein 16

2

0

High-throughput

0.559

High

923997

BMS1
Ribosome biogenesis protein BMS1

2

0

High-throughput

0.559

High

923998

FCF2
rRNA-processing protein FCF2

2

0

High-throughput

0.559

High

923999

SAS10
Something about silencing protein 10

2

0

High-throughput

0.559

High

924009

NOP14
Nucleolar complex protein 14

2

0

High-throughput

0.559

High

819426

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

527346

HSP72
Heat shock protein SSA2

2

0

High-throughput

0.528

High

921600

NRD1
Protein NRD1

1

0

Small-scale

0.513

High

448990

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.493

High

649515

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.493

High

665840

KPC1
Protein kinase C-like 1

1

0

High-throughput

0.493

High

779009

MYO3
Myosin-3

1

0

High-throughput

0.493

High

149887

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

512130

RS4A
Small ribosomal subunit protein eS4A

1

1

High-throughput

0.479

High

514171

RS16B
Small ribosomal subunit protein uS9B

1

1

High-throughput

0.479

High

747033

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

1

High-throughput

0.479

High

436091

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

442041

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

455191

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

512573

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

514762

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

585332

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

609077

SKI3
Superkiller protein 3

1

0

High-throughput

0.458

High

688934

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

707823

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

778463

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

782085

RL1D1
Ribosome biogenesis protein UTP30

1

0

High-throughput

0.458

High

803203

RIM4
Meiotic activator RIM4

1

0

Small-scale

0.458

High

816530

SNU13
13 kDa ribonucleoprotein-associated protein

1

0

High-throughput

0.458

High

825068

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

826199

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

826716

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

871036

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

923971

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

923990

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

924001

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

924006

NOT5
General negative regulator of transcription subunit 5

1

0

Small-scale

0.458

High

924007

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

924010

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

545800

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

923972

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

503169

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

510704

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.426

High

784177

RM24
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.269

Low

923977

PKH3
Serine/threonine-protein kinase PKH3

1

0

High-throughput

0.261

Low

511687

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.249

Low

511835

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.249

Low

513141

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

513897

RS11B
Small ribosomal subunit protein uS17B

1

0

High-throughput

0.249

Low

753507

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

924008

RS28A
Small ribosomal subunit protein eS28A

1

0

High-throughput

0.249

Low

631978

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.232

Low

823283

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025