Protein: ESF2
Pre-rRNA-processing protein ESF2 (18S rRNA factor 2)

Gene: ESF2
Organism: Saccharomyces cerevisiae S288C
Interactions: 115
UniProt ID: P53743

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001671 - ATPase activator activity
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

923257

ESF1
Pre-rRNA-processing protein ESF1

6

1

Small-scale

0.736

High

802885

DBP8
ATP-dependent RNA helicase DBP8

4

3

Small-scale

0.707

High

677507

KRR1
KRR1 small subunit processome component

4

2

High-throughput

0.693

High

923269

UTP12
U3 small nucleolar RNA-associated protein 12

4

3

Small-scale

0.693

High

678434

PWP2
Periodic tryptophan protein 2

4

2

Small-scale

0.678

High

632711

DBP4
ATP-dependent RNA helicase HCA4

3

7

Small-scale

0.672

High

798280

ENP1
Essential nuclear protein 1

3

1

High-throughput

0.658

High

585330

FBRL
rRNA 2'-O-methyltransferase fibrillarin

3

1

Small-scale

0.650

High

871035

NOL10
Ribosome biogenesis protein ENP2

3

1

Small-scale

0.650

High

923254

UTP21
U3 small nucleolar RNA-associated protein 21

3

4

Small-scale

0.650

High

923245

HAS1
ATP-dependent RNA helicase HAS1

2

8

Small-scale

0.637

High

917442

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

1

High-throughput

0.628

High

825545

UTP25
U3 small nucleolar RNA-associated protein 25

2

1

High-throughput

0.614

High

923278

NOP14
Nucleolar complex protein 14

2

1

High-throughput

0.614

High

844562

UTP10
U3 small nucleolar RNA-associated protein 10

3

0

Small-scale

0.613

High

923238

NAT10
RNA cytidine acetyltransferase

2

1

High-throughput

0.601

High

923247

DHR1
Probable ATP-dependent RNA helicase DHR1

2

3

High-throughput

0.601

High

923253

UTP13
U3 small nucleolar RNA-associated protein 13

2

3

High-throughput

0.601

High

923266

BMS1
Ribosome biogenesis protein BMS1

2

3

High-throughput

0.601

High

923273

NOP56
Nucleolar protein 56

2

1

High-throughput

0.601

High

923275

NOP58
Nucleolar protein 58

2

1

High-throughput

0.601

High

823368

UTP18
U3 small nucleolar RNA-associated protein 18

2

0

High-throughput

0.588

High

923236

ESF2
Pre-rRNA-processing protein ESF2

2

0

Small-scale

0.588

High

923241

UTP6
U3 small nucleolar RNA-associated protein 6

2

0

High-throughput

0.588

High

923274

RRP36
rRNA biogenesis protein RRP36

2

0

High-throughput

0.588

High

393121

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.588

High

818325

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

2

1

Small-scale

0.584

High

865149

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

1

Small-scale

0.584

High

918792

UTP22
U3 small nucleolar RNA-associated protein 22

2

1

Small-scale

0.584

High

923251

RRP5
rRNA biogenesis protein RRP5

2

1

Small-scale

0.584

High

923259

NOC4
Nucleolar complex protein 4

2

3

High-throughput

0.584

High

923262

UTP4
U3 small nucleolar RNA-associated protein 4

2

2

Small-scale

0.584

High

923250

UTP14
U3 small nucleolar RNA-associated protein 14

2

0

High-throughput

0.559

High

585993

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.541

High

722139

XPO1
Exportin-1

1

1

High-throughput

0.536

High

692599

NSR1
Nuclear localization sequence-binding protein

1

0

High-throughput

0.518

High

919591

NOP19
Nucleolar protein 19

1

0

High-throughput

0.518

High

923255

SGD1
Suppressor of glycerol defect protein 1

1

0

High-throughput

0.518

High

802761

RRP3
ATP-dependent rRNA helicase RRP3

1

5

High-throughput

0.515

High

923263

TSR1
Ribosome biogenesis protein TSR1

1

3

High-throughput

0.515

High

438466

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.493

High

898934

OCA1
Putative tyrosine-protein phosphatase OCA1

1

0

High-throughput

0.493

High

435261

RS3
Small ribosomal subunit protein uS3

1

1

Small-scale

0.479

High

488981

SWI6
Regulatory protein SWI6

1

1

High-throughput

0.479

High

514041

RL18B
Large ribosomal subunit protein eL18B

1

1

Small-scale

0.479

High

570096

RL3
Large ribosomal subunit protein uL3

1

1

Small-scale

0.479

High

673210

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.479

High

674754

RS2
Small ribosomal subunit protein uS5

1

2

Small-scale

0.479

High

689583

RS7A
Small ribosomal subunit protein eS7A

1

1

Small-scale

0.479

High

754313

DCA13
Protein SOF1

1

2

High-throughput

0.479

High

782084

RL1D1
Ribosome biogenesis protein UTP30

1

1

High-throughput

0.479

High

817605

UTP7
U3 small nucleolar RNA-associated protein 7

1

1

High-throughput

0.479

High

827569

RLP7
Ribosome biogenesis protein RLP7

1

1

Small-scale

0.479

High

923239

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

923242

UTP17
NET1-associated nuclear protein 1

1

3

High-throughput

0.479

High

923246

UTP5
U3 small nucleolar RNA-associated protein 5

1

3

High-throughput

0.479

High

923248

UTP15
U3 small nucleolar RNA-associated protein 15

1

1

High-throughput

0.479

High

923258

RRP9
Ribosomal RNA-processing protein 9

1

1

High-throughput

0.479

High

923260

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

923267

FCF2
rRNA-processing protein FCF2

1

1

High-throughput

0.479

High

923268

SAS10
Something about silencing protein 10

1

1

High-throughput

0.479

High

923276

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.479

High

923277

RRP12
Ribosomal RNA-processing protein 12

1

1

High-throughput

0.479

High

436477

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

668285

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

709904

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

735091

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

747032

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

0

High-throughput

0.458

High

758394

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

763602

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

806552

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

825067

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

826198

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

852585

ROK1
ATP-dependent RNA helicase ROK1

1

0

High-throughput

0.458

High

919151

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

923252

FCF1
rRNA-processing protein FCF1

1

0

High-throughput

0.458

High

923256

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

923264

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

923265

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

923279

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

923272

NSI1
RNA polymerase I termination factor

1

1

High-throughput

0.457

High

481708

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

524729

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

527325

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

545772

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

579831

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.445

High

727223

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

742102

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

752574

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

804345

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

819405

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

863981

JJJ2
J protein JJJ2

1

1

High-throughput

0.445

High

923237

JJJ1
J protein JJJ1

1

2

High-throughput

0.445

High

518354

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.438

High

678842

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.438

High

817552

YEQ9
Uncharacterized protein YER079W

1

0

High-throughput

0.438

High

923240

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.438

High

923271

AHC1
Protein AHC1

1

0

High-throughput

0.438

High

597231

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

676221

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

865025

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.426

High

923270

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

511833

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.269

Low

737755

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

0

High-throughput

0.269

Low

511249

RL20B
Large ribosomal subunit protein eL20B

1

0

Small-scale

0.249

Low

677149

LRE1
Laminarase-resistance protein LRE1

1

0

High-throughput

0.249

Low

707802

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

812535

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

923243

SLD5
DNA replication complex GINS protein SLD5

1

0

High-throughput

0.238

Low

923244

NAA30
N-alpha-acetyltransferase 30

1

0

High-throughput

0.238

Low

923249

ZWINT
Outer kinetochore KNL1 complex subunit KRE28

1

0

High-throughput

0.238

Low

811129

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low

823281

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

923261

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025