Protein: DEGS1
Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) (Retinol isomerase) (EC 5.2.1.-)

Gene: DEGS1
Organism: Homo sapiens
Interactions: 74
UniProt ID: O15121

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006636 - unsaturated fatty acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

178648

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

5

0

High-throughput

0.687

High

178634

SCAR3
Scavenger receptor class A member 3

3

0

High-throughput

0.638

High

178646

SIR2
NAD-dependent protein deacetylase sirtuin-2

3

0

High-throughput

0.638

High

178617

LPAR6
Lysophosphatidic acid receptor 6

2

4

High-throughput

0.611

High

178625

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

2

1

High-throughput

0.611

High

142120

NPT3
Sodium-dependent phosphate transport protein 3

2

0

High-throughput

0.602

High

178602

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.602

High

178633

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

0

High-throughput

0.602

High

178660

SEM4G
Semaphorin-4G

2

0

High-throughput

0.580

High

178596

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.536

High

178597

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

1

High-throughput

0.536

High

178614

OPRM
Mu-type opioid receptor

1

2

High-throughput

0.536

High

178615

APJ
Apelin receptor

1

3

High-throughput

0.536

High

178616

OPRX
Nociceptin receptor

1

2

High-throughput

0.536

High

178618

GPR12
G-protein coupled receptor 12

1

2

High-throughput

0.536

High

178619

PTH2R
Parathyroid hormone 2 receptor

1

1

High-throughput

0.536

High

178627

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.536

High

178661

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

178604

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

178663

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

1

0

High-throughput

0.518

High

178603

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.513

High

178606

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

0

High-throughput

0.513

High

178620

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

178626

CCG1
Voltage-dependent calcium channel gamma-1 subunit

1

0

High-throughput

0.513

High

178631

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.513

High

178636

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.513

High

178639

POTEE
POTE ankyrin domain family member E

1

0

High-throughput

0.513

High

178650

CLC2B
C-type lectin domain family 2 member B

1

0

High-throughput

0.513

High

178652

BSCL2
Seipin

1

0

High-throughput

0.513

High

178658

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.513

High

178662

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

0

High-throughput

0.513

High

178591

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.493

High

178621

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.493

High

178592

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

178608

5NTD
5'-nucleotidase

1

0

High-throughput

0.458

High

178611

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

178622

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

178624

NRG1
Pro-neuregulin-1, membrane-bound isoform

1

0

High-throughput

0.458

High

178628

FLOT2
Flotillin-2

1

0

High-throughput

0.458

High

178654

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

178656

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.458

High

178657

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.458

High

178647

CTL3
Choline transporter-like protein 3

1

1

High-throughput

0.445

High

178649

CTL1
Choline transporter-like protein 1

1

1

High-throughput

0.445

High

178598

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

178629

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.426

High

178640

MFSD6
Major facilitator superfamily domain-containing protein 6

1

0

High-throughput

0.426

High

178655

S19A3
Thiamine transporter 2

1

0

High-throughput

0.426

High

178638

CPLX2
Complexin-2

2

0

High-throughput

0.328

High

178594

IF2P
Eukaryotic translation initiation factor 5B

2

0

High-throughput

0.313

High

178595

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.279

Low

178601

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.269

Low

178632

EIPR1
EARP and GARP complex-interacting protein 1

1

0

High-throughput

0.269

Low

178593

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.249

Low

178599

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.249

Low

178600

ZTRF1
Zinc finger TRAF-type-containing protein 1

1

0

High-throughput

0.249

Low

178605

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

178607

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low

178609

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.249

Low

178610

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

178612

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

178613

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.249

Low

178623

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

178630

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.249

Low

178635

H2A2A
Histone H2A type 2-A

1

0

High-throughput

0.249

Low

178637

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

178641

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

178642

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.249

Low

178643

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

178644

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.249

Low

178645

FOXP4
Forkhead box protein P4

1

0

High-throughput

0.249

Low

178651

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.249

Low

178653

RADIL
Ras-associating and dilute domain-containing protein

1

0

High-throughput

0.249

Low

178659

MOB1A
MOB kinase activator 1A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025