Protein: L2GL1
Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)

Gene: L2GL1, LLGL1
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q15334

Gene Ontology (top 5):
GO:0000137 - Golgi cis cisterna
GO:0000139 - Golgi membrane
GO:0005096 - GTPase activator activity
GO:0005198 - structural molecule activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1051239

KPCZ
Protein kinase C zeta type

8

9

High-throughput

0.749

High

835676

KPCI
Protein kinase C iota type

7

9

Small-scale

0.744

High

1146340

PAR6B
Partitioning defective 6 homolog beta

6

8

High-throughput

0.735

High

1146320

KBTB7
Kelch repeat and BTB domain-containing protein 7

5

2

High-throughput

0.714

High

258890

DNJA2
DnaJ homolog subfamily A member 2

4

5

High-throughput

0.678

High

375541

RASK
GTPase KRas

4

7

High-throughput

0.676

High

1107737

SQSTM
Sequestosome-1

3

1

High-throughput

0.650

High

1146350

PAR6A
Partitioning defective 6 homolog alpha

2

8

High-throughput

0.628

High

1146319

PARD3
Partitioning defective 3 homolog

2

1

High-throughput

0.611

High

529841

TAU
Microtubule-associated protein tau

2

1

Small-scale

0.601

High

1146308

L2GL2
LLGL scribble cell polarity complex component 2

2

3

High-throughput

0.601

High

1146339

PAR6G
Partitioning defective 6 homolog gamma

2

8

High-throughput

0.601

High

1113163

CUL3
Cullin-3

2

0

High-throughput

0.585

High

241747

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

373937

RASN
GTPase NRas

2

7

High-throughput

0.584

High

411973

NTRK1
High affinity nerve growth factor receptor

2

5

High-throughput

0.584

High

540463

LAMP1
Lysosome-associated membrane glycoprotein 1

2

2

High-throughput

0.584

High

978023

RHOB
Rho-related GTP-binding protein RhoB

2

13

High-throughput

0.584

High

1146337

RANB9
Ran-binding protein 9

1

0

Small-scale

0.549

High

1146366

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

2

1

High-throughput

0.549

High

613355

VINC
Vinculin

1

1

High-throughput

0.536

High

1100663

STX3
Syntaxin-3

1

16

High-throughput

0.536

High

1146318

ARRD2
Arrestin domain-containing protein 2

1

4

High-throughput

0.536

High

1146323

ARL11
ADP-ribosylation factor-like protein 11

1

3

High-throughput

0.536

High

1146327

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1146328

ARRD3
Arrestin domain-containing protein 3

1

4

High-throughput

0.536

High

1146336

TRIB1
Tribbles homolog 1

1

3

High-throughput

0.536

High

1146342

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.536

High

720668

AGTR1
Type-1 angiotensin II receptor

1

0

High-throughput

0.518

High

347038

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

843578

HD
Huntingtin

1

0

High-throughput

0.513

High

921676

COPB
Coatomer subunit beta

1

0

High-throughput

0.513

High

1146315

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1146332

SPB12
Serpin B12

1

0

High-throughput

0.513

High

1146341

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

508010

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

1143997

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.489

High

139709

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

0

High-throughput

0.486

High

126610

RHOD
Rho-related GTP-binding protein RhoD

1

15

High-throughput

0.479

High

189576

STX7
Syntaxin-7

1

12

High-throughput

0.479

High

226037

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

341059

DIRA3
GTP-binding protein Di-Ras3

1

1

High-throughput

0.479

High

363319

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

374612

RASH
GTPase HRas

1

5

High-throughput

0.479

High

440084

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.479

High

463528

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

463970

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

4

High-throughput

0.479

High

465528

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.479

High

466266

RHOC
Rho-related GTP-binding protein RhoC

1

11

High-throughput

0.479

High

562063

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

581064

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

601300

RHOQ
Rho-related GTP-binding protein RhoQ

1

13

High-throughput

0.479

High

603989

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

605687

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.479

High

631236

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.479

High

710253

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

720233

UFO
Tyrosine-protein kinase receptor UFO

1

4

Small-scale

0.479

High

773190

MYH10
Myosin-10

1

1

Small-scale

0.479

High

830780

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

845647

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

900828

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.479

High

901827

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.479

High

910063

RND2
Rho-related GTP-binding protein RhoN

1

16

High-throughput

0.479

High

936332

AFAD
Afadin

1

2

High-throughput

0.479

High

953463

RAC3
Ras-related C3 botulinum toxin substrate 3

1

12

High-throughput

0.479

High

955193

CDC42
Cell division control protein 42 homolog

1

13

High-throughput

0.479

High

956299

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.479

High

962072

RHOA
Transforming protein RhoA

1

12

High-throughput

0.479

High

962747

RND3
Rho-related GTP-binding protein RhoE

1

16

High-throughput

0.479

High

975046

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

988384

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.479

High

1015453

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

1087118

STX4
Syntaxin-4

1

16

High-throughput

0.479

High

1144912

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.479

High

1146302

RHOH
Rho-related GTP-binding protein RhoH

1

13

High-throughput

0.479

High

1146303

NTRK3
NT-3 growth factor receptor

1

5

High-throughput

0.479

High

1146304

NTRK2
BDNF/NT-3 growth factors receptor

1

7

High-throughput

0.479

High

1146306

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1146310

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1146311

RHOU
Rho-related GTP-binding protein RhoU

1

15

High-throughput

0.479

High

1146313

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

1

High-throughput

0.479

High

1146316

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.479

High

1146321

RND1
Rho-related GTP-binding protein Rho6

1

16

High-throughput

0.479

High

1146330

RHOV
Rho-related GTP-binding protein RhoV

1

13

High-throughput

0.479

High

1146333

FMNL2
Formin-like protein 2

1

1

High-throughput

0.479

High

1146343

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

1146345

RHOJ
Rho-related GTP-binding protein RhoJ

1

13

High-throughput

0.479

High

1146348

RHOF
Rho-related GTP-binding protein RhoF

1

14

High-throughput

0.479

High

1146349

E41LA
Band 4.1-like protein 4A

1

1

High-throughput

0.479

High

1146351

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

1146353

RN146
E3 ubiquitin-protein ligase RNF146

1

1

Small-scale

0.479

High

1146356

DNJ5B
DnaJ homolog subfamily C member 5B

1

3

High-throughput

0.479

High

1146357

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1146360

ALK
ALK tyrosine kinase receptor

1

5

High-throughput

0.479

High

1146362

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

48633

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.458

High

158213

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

218209

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

293721

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

299204

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

372089

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

447048

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

556096

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

614689

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.458

High

642884

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

715594

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

880556

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

976282

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

986441

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1004061

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1041076

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1105933

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.458

High

1146301

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.458

High

1146305

OCLN
Occludin

1

0

High-throughput

0.458

High

1146309

RHDF2
Inactive rhomboid protein 2

1

0

High-throughput

0.458

High

1146324

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

1146334

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1146338

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.458

High

1146346

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1146347

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1146355

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

328020

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.445

High

679166

DNJB1
DnaJ homolog subfamily B member 1

1

5

High-throughput

0.445

High

727816

DNJA1
DnaJ homolog subfamily A member 1

1

5

High-throughput

0.445

High

952180

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.445

High

1146352

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.445

High

1146359

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.445

High

1146361

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

High-throughput

0.445

High

1146363

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.445

High

621646

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

970542

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1137703

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.437

High

1146322

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

248878

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

409390

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.426

High

934645

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

995050

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.426

High

1146344

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

3

High-throughput

0.407

High

1146364

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.407

High

588757

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.305

High

907439

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

Small-scale

0.292

High

722711

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

High-throughput

0.279

Low

1146331

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

1146354

SMAL1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

1

0

High-throughput

0.279

Low

1146365

DMXL1
DmX-like protein 1

1

0

High-throughput

0.279

Low

1146367

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.279

Low

327268

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

695522

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768254

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

904746

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

1146312

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1146314

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1146325

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1146335

CIC
Protein capicua homolog

1

0

High-throughput

0.249

Low

1146358

FBW1B
F-box/WD repeat-containing protein 11

1

0

High-throughput

0.249

Low

1146326

ACD
Adrenocortical dysplasia protein homolog

1

0

High-throughput

0.238

Low

1146307

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.232

Low

1146317

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.232

Low

1146329

F167A
Protein FAM167A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025