Protein: MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)

Gene: MD12L, MED12L
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q86YW9

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0008013 - beta-catenin binding
GO:0016592 - mediator complex
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1295672

MED10
Mediator of RNA polymerase II transcription subunit 10

2

2

High-throughput

0.789

High

1295682

MED13
Mediator of RNA polymerase II transcription subunit 13

2

5

High-throughput

0.776

High

881558

CDK8
Cyclin-dependent kinase 8

6

16

High-throughput

0.730

High

48985

MED19
Mediator of RNA polymerase II transcription subunit 19

5

2

High-throughput

0.718

High

219497

MED7
Mediator of RNA polymerase II transcription subunit 7

4

2

High-throughput

0.699

High

1108365

MED21
Mediator of RNA polymerase II transcription subunit 21

4

1

High-throughput

0.697

High

666863

CCNC
Cyclin-C

4

12

High-throughput

0.686

High

1151268

MED1
Mediator of RNA polymerase II transcription subunit 1

3

20

High-throughput

0.667

High

1295673

MED18
Mediator of RNA polymerase II transcription subunit 18

3

2

High-throughput

0.667

High

1295675

MED28
Mediator of RNA polymerase II transcription subunit 28

3

1

High-throughput

0.667

High

1295677

MED4
Mediator of RNA polymerase II transcription subunit 4

3

4

High-throughput

0.667

High

1295680

MED29
Mediator of RNA polymerase II transcription subunit 29

3

2

High-throughput

0.667

High

1295674

CDK19
Cyclin-dependent kinase 19

5

14

High-throughput

0.652

High

1295685

MED31
Mediator of RNA polymerase II transcription subunit 31

2

2

High-throughput

0.628

High

1259048

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

5

High-throughput

0.618

High

1295667

MED12
Mediator of RNA polymerase II transcription subunit 12

1

18

High-throughput

0.618

High

239595

MED14
Mediator of RNA polymerase II transcription subunit 14

2

20

High-throughput

0.611

High

282398

MED24
Mediator of RNA polymerase II transcription subunit 24

2

2

High-throughput

0.611

High

1149694

MED22
Mediator of RNA polymerase II transcription subunit 22

2

2

High-throughput

0.611

High

1295676

MED20
Mediator of RNA polymerase II transcription subunit 20

2

1

High-throughput

0.611

High

1295678

MED17
Mediator of RNA polymerase II transcription subunit 17

2

2

High-throughput

0.611

High

1295679

MED9
Mediator of RNA polymerase II transcription subunit 9

2

1

High-throughput

0.611

High

1295681

MED11
Mediator of RNA polymerase II transcription subunit 11

2

2

High-throughput

0.611

High

1295683

MED23
Mediator of RNA polymerase II transcription subunit 23

2

5

High-throughput

0.611

High

853814

MK09
Mitogen-activated protein kinase 9

2

9

High-throughput

0.553

High

1061761

TLE5
TLE family member 5

2

2

High-throughput

0.553

High

1295671

CDC5L
Cell division cycle 5-like protein

1

8

High-throughput

0.536

High

219197

LTOR5
Ragulator complex protein LAMTOR5

1

2

High-throughput

0.494

High

520184

ANDR
Androgen receptor

1

20

Small-scale

0.481

High

287802

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.479

High

336009

MED26
Mediator of RNA polymerase II transcription subunit 26

1

1

High-throughput

0.479

High

1241389

MED27
Mediator of RNA polymerase II transcription subunit 27

1

2

High-throughput

0.479

High

1295668

MED8
Mediator of RNA polymerase II transcription subunit 8

1

2

High-throughput

0.479

High

1295669

MED30
Mediator of RNA polymerase II transcription subunit 30

1

2

High-throughput

0.479

High

1295684

MED16
Mediator of RNA polymerase II transcription subunit 16

1

2

High-throughput

0.479

High

372487

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.445

High

912084

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.437

High

942728

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

17

High-throughput

0.437

High

1216670

CROCC
Rootletin

1

14

High-throughput

0.437

High

1257784

ACD11
Acyl-CoA dehydrogenase family member 11

1

2

High-throughput

0.437

High

1295670

MED15
Mediator of RNA polymerase II transcription subunit 15

1

19

High-throughput

0.437

High

76428

B4DUB1
cyclin-dependent kinase

1

15

High-throughput

0.407

High

95749

E5RFK5
Cyclin-C

1

12

High-throughput

0.407

High

956675

CKS1
Cyclin-dependent kinases regulatory subunit 1

2

0

High-throughput

0.316

High

1220014

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1295666

MSRB3
Methionine-R-sulfoxide reductase B3

2

0

High-throughput

0.316

High

532735

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.269

Low

1119192

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025