Protein: MED11
Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11)

Gene: MED11
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q9P086

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1431402

MED28
Mediator of RNA polymerase II transcription subunit 28

6

1

Small-scale

0.943

High

1391343

MED8
Mediator of RNA polymerase II transcription subunit 8

5

2

High-throughput

0.919

High

1149718

MED22
Mediator of RNA polymerase II transcription subunit 22

4

2

Small-scale

0.911

High

1414150

MED18
Mediator of RNA polymerase II transcription subunit 18

4

1

High-throughput

0.909

High

1450384

MED17
Mediator of RNA polymerase II transcription subunit 17

4

1

High-throughput

0.900

High

1393385

MED30
Mediator of RNA polymerase II transcription subunit 30

2

2

High-throughput

0.811

High

49027

MED19
Mediator of RNA polymerase II transcription subunit 19

9

1

Small-scale

0.757

High

1413638

MED10
Mediator of RNA polymerase II transcription subunit 10

8

1

Small-scale

0.754

High

1451888

MED29
Mediator of RNA polymerase II transcription subunit 29

7

1

Small-scale

0.750

High

881617

CDK8
Cyclin-dependent kinase 8

6

2

High-throughput

0.734

High

219524

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.722

High

1151302

MED1
Mediator of RNA polymerase II transcription subunit 1

5

1

Small-scale

0.718

High

1372207

MED12
Mediator of RNA polymerase II transcription subunit 12

5

2

High-throughput

0.718

High

1446531

MED4
Mediator of RNA polymerase II transcription subunit 4

4

1

High-throughput

0.702

High

1416408

CDK19
Cyclin-dependent kinase 19

4

2

High-throughput

0.699

High

1436783

MED20
Mediator of RNA polymerase II transcription subunit 20

4

1

High-throughput

0.699

High

666923

CCNC
Cyclin-C

4

1

High-throughput

0.694

High

1108410

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

High-throughput

0.690

High

336036

MED26
Mediator of RNA polymerase II transcription subunit 26

4

0

High-throughput

0.670

High

1451135

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.670

High

282427

MED24
Mediator of RNA polymerase II transcription subunit 24

3

1

High-throughput

0.667

High

1453731

MED13
Mediator of RNA polymerase II transcription subunit 13

3

2

High-throughput

0.662

High

1453732

MED23
Mediator of RNA polymerase II transcription subunit 23

2

1

High-throughput

0.628

High

1453734

MED31
Mediator of RNA polymerase II transcription subunit 31

2

1

High-throughput

0.628

High

239626

MED14
Mediator of RNA polymerase II transcription subunit 14

2

2

High-throughput

0.611

High

287826

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.611

High

1241420

MED27
Mediator of RNA polymerase II transcription subunit 27

2

1

High-throughput

0.611

High

1259075

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

2

2

High-throughput

0.611

High

1295681

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

2

High-throughput

0.611

High

1401573

MED15
Mediator of RNA polymerase II transcription subunit 15

2

1

High-throughput

0.611

High

1453733

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.611

High

621776

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.585

High

621997

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.585

High

667488

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.585

High

723125

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

260555

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

1244768

SYCE2
Synaptonemal complex central element protein 2

2

0

High-throughput

0.580

High

1389699

SGF29
SAGA-associated factor 29

2

0

High-throughput

0.580

High

1452508

ABI2
Abl interactor 2

2

0

High-throughput

0.580

High

1453736

NDK7
Nucleoside diphosphate kinase homolog 7

2

0

High-throughput

0.580

High

1380214

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

1259290

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

High-throughput

0.536

High

564473

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

192875

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

1025153

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.513

High

1057278

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.513

High

1239682

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.513

High

1243785

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1453735

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

1141338

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1407428

EPAS1
Endothelial PAS domain-containing protein 1

1

1

Small-scale

0.479

High

787805

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

912144

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

976168

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

1151396

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1257835

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1397503

CI072
Guanine nucleotide exchange factor C9orf72

1

0

Small-scale

0.426

High

1401892

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

95763

E5RFK5
Cyclin-C

1

1

High-throughput

0.407

High

51373

SRCRL
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

2

0

High-throughput

0.316

High

658555

GCSH
Glycine cleavage system H protein, mitochondrial

2

0

High-throughput

0.316

High

1330103

USBP1
Harmonin-binding protein USHBP1

2

0

High-throughput

0.316

High

1393004

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

1428204

NDEL1
Nuclear distribution protein nudE-like 1

2

0

High-throughput

0.316

High

1322803

CNTRB
Centrobin

1

0

High-throughput

0.279

Low

423350

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

387571

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025