Protein: MED27
Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) (P37 TRAP/SMCC/PC2 subunit) (Transcriptional coactivator CRSP34)

Gene: MED27
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q6P2C8

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005667 - transcription regulator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1241414

MED20
Mediator of RNA polymerase II transcription subunit 20

5

1

Small-scale

0.930

High

881547

CDK8
Cyclin-dependent kinase 8

9

3

High-throughput

0.754

High

48976

MED19
Mediator of RNA polymerase II transcription subunit 19

9

1

Small-scale

0.754

High

1151259

MED1
Mediator of RNA polymerase II transcription subunit 1

6

1

Small-scale

0.733

High

1241398

MED12
Mediator of RNA polymerase II transcription subunit 12

6

2

High-throughput

0.733

High

1241411

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

1241409

MED10
Mediator of RNA polymerase II transcription subunit 10

6

1

Small-scale

0.732

High

1241412

MED28
Mediator of RNA polymerase II transcription subunit 28

6

1

Small-scale

0.732

High

666848

CCNC
Cyclin-C

6

1

High-throughput

0.729

High

219493

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.722

High

1241410

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.722

High

1149690

MED22
Mediator of RNA polymerase II transcription subunit 22

5

1

Small-scale

0.721

High

1241415

MED4
Mediator of RNA polymerase II transcription subunit 4

5

2

High-throughput

0.718

High

1241416

MED17
Mediator of RNA polymerase II transcription subunit 17

5

1

Small-scale

0.718

High

1241419

MED29
Mediator of RNA polymerase II transcription subunit 29

4

1

High-throughput

0.699

High

1241401

MED30
Mediator of RNA polymerase II transcription subunit 30

4

1

Small-scale

0.696

High

1108355

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

High-throughput

0.690

High

336004

MED26
Mediator of RNA polymerase II transcription subunit 26

4

0

High-throughput

0.670

High

282390

MED24
Mediator of RNA polymerase II transcription subunit 24

3

1

High-throughput

0.667

High

1241387

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

2

High-throughput

0.667

High

287797

MED6
Mediator of RNA polymerase II transcription subunit 6

3

1

Small-scale

0.662

High

1241422

MED13
Mediator of RNA polymerase II transcription subunit 13

3

2

High-throughput

0.662

High

1241417

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.661

High

239587

MED14
Mediator of RNA polymerase II transcription subunit 14

3

2

Small-scale

0.656

High

1241400

MED8
Mediator of RNA polymerase II transcription subunit 8

3

1

Small-scale

0.656

High

1241423

MED23
Mediator of RNA polymerase II transcription subunit 23

3

2

High-throughput

0.656

High

396338

ESR1
Estrogen receptor

3

3

Small-scale

0.641

High

621668

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

0

Small-scale

0.638

High

1241425

MED31
Mediator of RNA polymerase II transcription subunit 31

2

1

High-throughput

0.628

High

1241404

MED15
Mediator of RNA polymerase II transcription subunit 15

2

1

High-throughput

0.611

High

1241420

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.611

High

1241424

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.611

High

192826

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.602

High

621896

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

667341

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.585

High

722992

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

958971

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.585

High

260092

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.559

High

912193

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.547

High

277719

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.536

High

502020

H2AZ
Histone H2A.Z

1

3

High-throughput

0.536

High

542550

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

1039520

TOP2B
DNA topoisomerase 2-beta

1

1

High-throughput

0.536

High

1162994

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1241388

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

High-throughput

0.536

High

1241390

H2A2B
Histone H2A type 2-B

1

2

High-throughput

0.536

High

1241392

H2B3B
Histone H2B type 3-B

1

1

High-throughput

0.536

High

1241407

H2A1J
Histone H2A type 1-J

1

2

High-throughput

0.536

High

1241408

H2AJ
Histone H2A.J

1

2

High-throughput

0.536

High

1241421

H2AW
Core histone macro-H2A.2

1

4

High-throughput

0.536

High

776086

SOX5
Transcription factor SOX-5

1

0

High-throughput

0.518

High

1054726

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.518

High

1241393

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.518

High

455802

H10
Histone H1.0

1

0

High-throughput

0.513

High

927359

ATX1
Ataxin-1

1

0

High-throughput

0.513

High

1241385

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1241402

ZN512
Zinc finger protein 512

1

0

High-throughput

0.513

High

1241426

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

283492

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

341597

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

520138

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

1226885

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1241389

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

2

High-throughput

0.479

High

316294

RECQ5
ATP-dependent DNA helicase Q5

1

0

High-throughput

0.458

High

326348

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

372325

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

387531

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.458

High

401004

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

414038

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

588946

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

695733

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

768450

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

787754

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

830931

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

862227

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

912073

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

920046

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

923504

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

976103

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

983666

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1026429

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1083386

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

0

High-throughput

0.458

High

1088879

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1151341

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1211995

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

1217584

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

1241386

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1241391

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1241394

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1241395

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1241399

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1241403

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1241406

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

1241413

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

1241418

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.458

High

95747

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1207510

Q5JWT2
Mediator of RNA polymerase II transcription subunit 23

1

2

High-throughput

0.445

High

1214702

Q5T911
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.445

High

1241397

ESR2
Estrogen receptor beta

1

3

High-throughput

0.445

High

1241405

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

76426

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

886962

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

390252

FETA
Alpha-fetoprotein

1

0

High-throughput

0.282

High

1241396

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1231989

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

506015

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025