Protein: SETD2
Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)

Gene: SETD2
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q9BYW2

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001763 - morphogenesis of a branching structure
GO:0001843 - neural tube closure
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1317591

WDR37
WD repeat-containing protein 37

2

11

High-throughput

0.789

High

935204

H31
Histone H3.1

2

20

Small-scale

0.738

High

160759

AURKA
Aurora kinase A

4

5

High-throughput

0.694

High

833967

CLK2
Dual specificity protein kinase CLK2

3

6

High-throughput

0.675

High

1086306

H31T
Histone H3.1t

1

20

Small-scale

0.647

High

1317575

SETD2
Histone-lysine N-methyltransferase SETD2

1

17

Small-scale

0.647

High

791948

HD
Huntingtin

3

2

Small-scale

0.644

High

341291

FA9
Coagulation factor IX

2

2

High-throughput

0.628

High

1261888

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

6

High-throughput

0.628

High

1317578

NXF2
Nuclear RNA export factor 2

2

1

High-throughput

0.628

High

1317589

HSPB8
Heat shock protein beta-8

2

3

High-throughput

0.628

High

625023

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

10

Small-scale

0.624

High

1238115

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

6

High-throughput

0.618

High

808896

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.618

High

917878

H4
Histone H4

1

8

High-throughput

0.618

High

980866

TLE3
Transducin-like enhancer protein 3

1

11

High-throughput

0.618

High

1244474

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1260899

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.618

High

1288291

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.618

High

1317577

WWTR1
WW domain-containing transcription regulator protein 1

1

9

High-throughput

0.618

High

1317584

NLE1
Notchless protein homolog 1

1

4

High-throughput

0.618

High

1139173

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.602

High

164149

ARHGA
Rho guanine nucleotide exchange factor 10

3

3

High-throughput

0.599

High

214365

SPOP
Speckle-type POZ protein

2

3

Small-scale

0.586

High

1134075

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.586

High

387451

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

1302414

IWS1
Protein IWS1 homolog

2

8

Small-scale

0.584

High

950272

SMAD3
Mothers against decapentaplegic homolog 3

1

11

High-throughput

0.573

High

370370

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1300555

ARX
Homeobox protein ARX

1

6

High-throughput

0.541

High

127861

SAP18
Histone deacetylase complex subunit SAP18

1

2

High-throughput

0.536

High

312963

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.536

High

446781

SNRPA
U1 small nuclear ribonucleoprotein A

1

7

High-throughput

0.536

High

488797

ARAF
Serine/threonine-protein kinase A-Raf

1

2

High-throughput

0.536

High

508696

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

509984

VDR
Vitamin D3 receptor

1

20

High-throughput

0.536

High

528025

RINI
Ribonuclease inhibitor

1

2

High-throughput

0.536

High

539140

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

541135

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

8

High-throughput

0.536

High

817743

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.536

High

818438

SOX2
Transcription factor SOX-2

1

16

High-throughput

0.536

High

899671

FGF12
Fibroblast growth factor 12

1

1

High-throughput

0.536

High

931843

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.536

High

942926

SRPK2
SRSF protein kinase 2

1

8

High-throughput

0.536

High

996877

SSRP1
FACT complex subunit SSRP1

1

18

High-throughput

0.536

High

1029077

SRSF6
Serine/arginine-rich splicing factor 6

1

16

High-throughput

0.536

High

1050049

SCRIB
Protein scribble homolog

1

1

High-throughput

0.536

High

1054567

RBM39
RNA-binding protein 39

1

8

High-throughput

0.536

High

1070616

RNPS1
RNA-binding protein with serine-rich domain 1

1

7

High-throughput

0.536

High

1074227

SF3A1
Splicing factor 3A subunit 1

1

5

High-throughput

0.536

High

1084605

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

12

High-throughput

0.536

High

1157372

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

3

High-throughput

0.536

High

1222390

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

7

High-throughput

0.536

High

1241834

ZBT44
Zinc finger and BTB domain-containing protein 44

1

17

High-throughput

0.536

High

1246590

CTCFL
Transcriptional repressor CTCFL

1

1

High-throughput

0.536

High

1272809

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.536

High

1317582

CBX8
Chromobox protein homolog 8

1

20

High-throughput

0.536

High

1317588

CPNE7
Copine-7

1

2

High-throughput

0.536

High

418627

NPM
Nucleophosmin

1

5

High-throughput

0.515

High

828622

CENPF
Centromere protein F

1

12

High-throughput

0.515

High

63943

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.513

High

245208

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.513

High

448808

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

599072

ZNF10
Zinc finger protein 10

1

0

High-throughput

0.513

High

1079146

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.513

High

1317587

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

868722

ATX1
Ataxin-1

1

1

High-throughput

0.508

High

1300928

CIC
Protein capicua homolog

1

16

High-throughput

0.508

High

1316273

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

9

High-throughput

0.494

High

945643

CXCL6
C-X-C motif chemokine 6

1

3

High-throughput

0.489

High

1201403

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

1

High-throughput

0.489

High

1217246

CCD71
Coiled-coil domain-containing protein 71

1

3

High-throughput

0.489

High

1298008

RN145
RING finger protein 145

1

2

High-throughput

0.489

High

199142

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

2

High-throughput

0.481

High

163234

XPO1
Exportin-1

1

4

High-throughput

0.479

High

164474

TRI66
Tripartite motif-containing protein 66

1

19

High-throughput

0.479

High

228600

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

244896

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

246611

MCE1
mRNA-capping enzyme

1

7

High-throughput

0.479

High

379832

MYCN
N-myc proto-oncogene protein

1

8

Small-scale

0.479

High

582478

NUCL
Nucleolin

1

6

High-throughput

0.479

High

652166

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

652981

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

High-throughput

0.479

High

800516

CBX5
Chromobox protein homolog 5

1

20

High-throughput

0.479

High

802494

ATRX
Transcriptional regulator ATRX

1

20

Small-scale

0.479

High

1026531

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

1027242

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1042470

CUL3
Cullin-3

1

10

High-throughput

0.479

High

1055472

DHX8
ATP-dependent RNA helicase DHX8

1

5

High-throughput

0.479

High

1056971

MDC1
Mediator of DNA damage checkpoint protein 1

1

10

High-throughput

0.479

High

1061602

CUL7
Cullin-7

1

3

High-throughput

0.479

High

1188821

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1193174

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

1221712

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

1236480

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.479

High

1269543

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1270910

KAT6A
Histone acetyltransferase KAT6A

1

16

High-throughput

0.479

High

1292201

AURKB
Aurora kinase B

1

5

High-throughput

0.479

High

1311536

PCGF1
Polycomb group RING finger protein 1

1

10

Small-scale

0.479

High

1313153

DDX23
Probable ATP-dependent RNA helicase DDX23

1

5

High-throughput

0.479

High

1315219

CECR2
Chromatin remodeling regulator CECR2

1

20

High-throughput

0.479

High

1317576

TRI31
E3 ubiquitin-protein ligase TRIM31

1

5

High-throughput

0.479

High

1317579

GAN
Gigaxonin

1

2

High-throughput

0.479

High

1317581

SP110
Sp110 nuclear body protein

1

19

High-throughput

0.479

High

1317585

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1317590

BRPF3
Bromodomain and PHD finger-containing protein 3

1

20

High-throughput

0.479

High

1317592

TRRAP
Transformation/transcription domain-associated protein

1

5

High-throughput

0.479

High

1200637

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1044124

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.445

High

1317580

LN28A
Protein lin-28 homolog A

1

9

High-throughput

0.445

High

1220272

DHX40
Probable ATP-dependent RNA helicase DHX40

1

6

High-throughput

0.437

High

1317583

LUC7L
Putative RNA-binding protein Luc7-like 1

1

1

High-throughput

0.437

High

92354

E9PB39
Rho guanine nucleotide exchange factor 10

1

4

High-throughput

0.407

High

1149857

SCAR3
Scavenger receptor class A member 3

3

0

High-throughput

0.347

High

991116

PIGF
Phosphatidylinositol-glycan biosynthesis class F protein

1

0

High-throughput

0.279

Low

1101758

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1101869

S35G1
Solute carrier family 35 member G1

1

0

High-throughput

0.279

Low

1172626

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.279

Low

1245842

RASF8
Ras association domain-containing protein 8

1

0

High-throughput

0.279

Low

1256537

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.279

Low

1309730

PSD2
PH and SEC7 domain-containing protein 2

1

0

High-throughput

0.279

Low

1317586

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

1317593

O10H1
Olfactory receptor 10H1

1

0

High-throughput

0.279

Low

1241607

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024