Protein: LAS1L
Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog)

Gene: LAS1L
Organism: Homo sapiens
Interactions: 183
UniProt ID: Q9Y4W2

Gene Ontology (top 5):
GO:0000460 - maturation of 5.8S rRNA
GO:0000470 - maturation of LSU-rRNA
GO:0003723 - RNA binding
GO:0004519 - endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1211369

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

4

2

Small-scale

0.881

High

1414879

WDR18
WD repeat-containing protein 18

6

3

Small-scale

0.726

High

1316606

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

5

2

Small-scale

0.713

High

1433818

SENP3
Sentrin-specific protease 3

5

1

Small-scale

0.706

High

288832

NPM3
Nucleoplasmin-3

3

1

High-throughput

0.675

High

447624

NPM
Nucleophosmin

3

1

High-throughput

0.667

High

373608

MYC
Myc proto-oncogene protein

4

0

High-throughput

0.648

High

134194

IPO5
Importin-5

3

0

Small-scale

0.638

High

644157

FBRL
rRNA 2'-O-methyltransferase fibrillarin

3

0

High-throughput

0.616

High

1161778

IF16
Gamma-interferon-inducible protein 16

2

3

High-throughput

0.611

High

1235589

IFIX
Pyrin and HIN domain-containing protein 1

2

3

High-throughput

0.611

High

339017

CBX6
Chromobox protein homolog 6

2

0

High-throughput

0.602

High

1114750

CUL3
Cullin-3

2

0

High-throughput

0.585

High

487925

PARP1
Poly [ADP-ribose] polymerase 1

2

1

High-throughput

0.584

High

964525

SUMO2
Small ubiquitin-related modifier 2

2

0

High-throughput

0.577

High

831710

CCNF
Cyclin-F

2

0

High-throughput

0.576

High

397317

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

129595

MEN1
Menin

2

0

High-throughput

0.559

High

401761

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.559

High

979380

RS6
Small ribosomal subunit protein eS6

2

0

High-throughput

0.559

High

1452003

TEX10
Testis-expressed protein 10

2

0

Small-scale

0.559

High

166210

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

833233

MNDA
Myeloid cell nuclear differentiation antigen

1

3

High-throughput

0.536

High

922291

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

993049

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

1006825

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.536

High

1291312

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1402656

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

1413433

RBM42
RNA-binding protein 42

1

1

High-throughput

0.536

High

1462459

SRPK3
SRSF protein kinase 3

1

2

High-throughput

0.536

High

1209840

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.528

High

303670

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

417872

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

418541

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

457798

TBB5
Tubulin beta chain

1

0

High-throughput

0.513

High

479498

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

504846

H2AB1
Histone H2A-Bbd type 1

1

0

High-throughput

0.513

High

624187

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

625727

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

634711

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

694096

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

813266

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

859520

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

872936

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

884285

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

886627

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

960620

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.513

High

970197

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1120522

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1126589

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

1243078

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.513

High

1288311

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1349871

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

1360541

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1404543

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1416972

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.513

High

1417916

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1430799

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.513

High

1459785

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1462298

MAGD2
Melanoma-associated antigen D2

1

0

High-throughput

0.513

High

1490630

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

1491333

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

High-throughput

0.513

High

1491456

NGN3
Neurogenin-3

1

0

High-throughput

0.513

High

1403552

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.493

High

1460264

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

876653

NEST
Nestin

1

1

High-throughput

0.489

High

911964

JAK3
Tyrosine-protein kinase JAK3

1

1

High-throughput

0.489

High

1367683

ESR2
Estrogen receptor beta

1

2

High-throughput

0.484

High

173608

XPO1
Exportin-1

1

1

High-throughput

0.479

High

191179

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

346557

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

577516

ETS1
Protein C-ets-1

1

1

High-throughput

0.479

High

590130

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

731738

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

766053

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

832598

ETV3
ETS translocation variant 3

1

1

High-throughput

0.479

High

877583

LHX1
LIM/homeobox protein Lhx1

1

1

High-throughput

0.479

High

881634

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.479

High

1008947

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

1088640

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1089941

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.479

High

1096880

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1133072

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

1138200

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

1152505

T22D1
TSC22 domain family protein 1

1

1

High-throughput

0.479

High

1329966

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1339069

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

1381619

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

2

High-throughput

0.479

High

1387662

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

1404871

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1405925

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

1414634

DDX23
Probable ATP-dependent RNA helicase DDX23

1

1

High-throughput

0.479

High

1429830

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.479

High

1433871

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

1

High-throughput

0.479

High

1448264

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1491457

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

156100

SOCS6
Suppressor of cytokine signaling 6

1

1

High-throughput

0.470

High

1228504

FTM
Protein fantom

1

1

High-throughput

0.470

High

125680

LEG9
Galectin-9

1

0

High-throughput

0.458

High

141187

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

158031

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

194409

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

243397

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

260650

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

320183

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

370825

FOS
Protein c-Fos

1

0

High-throughput

0.458

High

508894

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

607266

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

696969

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

697311

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

714550

PML
Protein PML

1

0

High-throughput

0.458

High

769610

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

800190

COIL
Coilin

1

0

High-throughput

0.458

High

879663

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

883744

CENPA
Histone H3-like centromeric protein A

1

0

High-throughput

0.458

High

897438

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

937999

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

971353

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

980604

H4
Histone H4

1

0

High-throughput

0.458

High

981198

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

982897

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

985095

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1127283

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1129799

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.458

High

1133757

NFIX
Nuclear factor 1 X-type

1

0

High-throughput

0.458

High

1135873

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1238522

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

1277033

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1280637

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1311900

DHX40
Probable ATP-dependent RNA helicase DHX40

1

0

High-throughput

0.458

High

1313567

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1329033

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.458

High

1347007

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1352868

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1380696

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1385668

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1393872

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1397599

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1399877

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1401340

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.458

High

1406818

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.458

High

1418658

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

0

High-throughput

0.458

High

1428688

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1429417

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1435499

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1436583

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1447498

ANLN
Anillin

1

0

High-throughput

0.458

High

1449414

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

Small-scale

0.458

High

1451484

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1453067

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1454381

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1491278

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

965369

WDR5
WD repeat-containing protein 5

1

1

Small-scale

0.445

High

412879

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1414992

CP250
Centrosome-associated protein CEP250

1

1

High-throughput

0.437

High

1434334

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

294768

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

1058377

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.426

High

1130552

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1417631

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.426

High

1461387

AGO1
Protein argonaute-1

1

0

High-throughput

0.426

High

1462629

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.426

High

165838

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

0

High-throughput

0.279

Low

505214

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

549032

KPSH1
Serine/threonine-protein kinase H1

1

0

High-throughput

0.279

Low

1403485

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1417996

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.279

Low

1449473

NRBP2
Nuclear receptor-binding protein 2

1

0

High-throughput

0.279

Low

1353741

MOT10
Monocarboxylate transporter 10

1

0

High-throughput

0.269

Low

124544

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

272577

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

294584

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

902915

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.249

Low

1126226

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1135200

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1253023

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1256256

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1324121

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1450986

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

Small-scale

0.249

Low

1461732

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1313890

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.232

Low

1400207

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.232

Low

1401560

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025