Protein: DNLI1
DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1)

Gene: DNLI1, LIG1
Organism: Homo sapiens
Interactions: 55
UniProt ID: P18858

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003909 - DNA ligase activity
GO:0003910 - DNA ligase (ATP) activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

579484

UHRF1
E3 ubiquitin-protein ligase UHRF1

5

7

Small-scale

0.713

High

579483

EHMT2
Histone-lysine N-methyltransferase EHMT2

3

5

Small-scale

0.655

High

517041

PCNA
Proliferating cell nuclear antigen

3

5

Small-scale

0.646

High

579479

RN166
E3 ubiquitin-protein ligase RNF166

2

3

High-throughput

0.611

High

579461

DCAF7
DDB1- and CUL4-associated factor 7

1

4

Small-scale

0.578

High

579462

CBX3
Chromobox protein homolog 3

2

8

Small-scale

0.563

High

388217

HSPB1
Heat shock protein beta-1

1

5

High-throughput

0.541

High

579475

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.536

High

559541

H12
Histone H1.2

1

8

High-throughput

0.515

High

160373

AURKA
Aurora kinase A

1

0

High-throughput

0.513

High

416566

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

579456

RGS2
Regulator of G-protein signaling 2

1

2

High-throughput

0.508

High

579489

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

5

Small-scale

0.501

High

579460

MRE11
Double-strand break repair protein MRE11

1

1

Small-scale

0.481

High

408550

KPCB
Protein kinase C beta type

1

0

Small-scale

0.480

High

179539

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

8

High-throughput

0.479

High

226479

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

345886

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.479

High

384236

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

575256

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

579453

CDK2
Cyclin-dependent kinase 2

1

3

Small-scale

0.479

High

579454

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

579455

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.479

High

579457

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

579463

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

579464

CUL4A
Cullin-4A

1

9

Small-scale

0.479

High

579465

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.479

High

579466

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

579467

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.479

High

579471

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

579487

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.479

High

579490

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

579472

UBE3B
Ubiquitin-protein ligase E3B

1

2

High-throughput

0.470

High

238251

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.458

High

245875

HUS1
Checkpoint protein HUS1

1

0

Small-scale

0.458

High

579473

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

579480

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

579481

THOC1
THO complex subunit 1

1

0

High-throughput

0.458

High

579485

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.458

High

381117

TBB4A
Tubulin beta-4A chain

1

2

High-throughput

0.457

High

579458

INPP
Inositol polyphosphate 1-phosphatase

1

0

High-throughput

0.438

High

579470

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

579478

NUDC2
NudC domain-containing protein 2

1

3

High-throughput

0.437

High

579488

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

579459

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

579476

CDYL2
Chromodomain Y-like protein 2

1

2

Small-scale

0.408

High

579486

PHF20
PHD finger protein 20

1

4

Small-scale

0.408

High

579491

CDYL
Chromodomain Y-like protein

1

3

Small-scale

0.408

High

579492

CDY1
Testis-specific chromodomain protein Y 1

1

2

Small-scale

0.408

High

579474

MIER1
Mesoderm induction early response protein 1

1

0

Small-scale

0.391

High

579482

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

0

Small-scale

0.391

High

323577

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

579468

SPXN5
Sperm protein associated with the nucleus on the X chromosome N5

1

0

High-throughput

0.279

Low

579469

SYT6
Synaptotagmin-6

1

0

High-throughput

0.279

Low

579477

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024