Protein: NPL4
Nuclear protein localization protein 4 homolog (Protein NPL4)

Gene: NPL4, NPLOC4
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q8TAT6

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

875135

TERA
Transitional endoplasmic reticulum ATPase

27

6

Small-scale

0.991

High

476084

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

10

3

Small-scale

0.973

High

1251695

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

15

7

Small-scale

0.759

High

228121

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.754

High

1251730

FAF1
FAS-associated factor 1

6

9

Small-scale

0.726

High

509689

UBL4A
Ubiquitin-like protein 4A

1

4

High-throughput

0.665

High

924360

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.656

High

1251710

ASPC1
Tether containing UBX domain for GLUT4

3

1

High-throughput

0.650

High

1251732

NSF1C
NSFL1 cofactor p47

3

2

Small-scale

0.640

High

513751

CP19A
Aromatase

2

1

High-throughput

0.628

High

398039

ISG15
Ubiquitin-like protein ISG15

1

4

Small-scale

0.618

High

1251727

UBQL2
Ubiquilin-2

1

2

High-throughput

0.618

High

299424

UBXN7
UBX domain-containing protein 7

2

7

High-throughput

0.611

High

1251699

FAF2
FAS-associated factor 2

2

8

High-throughput

0.611

High

1251707

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.606

High

242872

TRI13
E3 ubiquitin-protein ligase TRIM13

2

0

High-throughput

0.602

High

622695

ERD21
ER lumen protein-retaining receptor 1

2

0

High-throughput

0.602

High

1126592

AG10B
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

2

0

High-throughput

0.602

High

1251703

UBX10
UBX domain-containing protein 10

2

0

High-throughput

0.585

High

1251722

EKI2
Ethanolamine kinase 2

2

0

High-throughput

0.585

High

1251729

AMFR
E3 ubiquitin-protein ligase AMFR

2

1

Small-scale

0.584

High

1116273

VP26B
Vacuolar protein sorting-associated protein 26B

2

0

High-throughput

0.580

High

1080141

EZH2
Histone-lysine N-methyltransferase EZH2

2

0

High-throughput

0.576

High

1251701

VCIP1
Deubiquitinating protein VCPIP1

2

0

High-throughput

0.576

High

740018

TGFR2
TGF-beta receptor type-2

2

0

High-throughput

0.575

High

134666

NPT3
Sodium-dependent phosphate transport protein 3

2

1

High-throughput

0.574

High

977418

KCNC4
Potassium voltage-gated channel subfamily C member 4

2

1

High-throughput

0.574

High

374573

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

Small-scale

0.561

High

890280

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

116696

UBXN8
UBX domain-containing protein 8

1

5

High-throughput

0.536

High

979329

UBXN1
UBX domain-containing protein 1

1

6

High-throughput

0.536

High

1108432

PTHD3
Patched domain-containing protein 3

1

2

High-throughput

0.536

High

1092652

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

1

High-throughput

0.515

High

259099

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.513

High

403290

LA
Lupus La protein

1

0

High-throughput

0.513

High

834991

PSN2
Presenilin-2

1

0

High-throughput

0.513

High

1184839

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.513

High

1251734

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

0

High-throughput

0.513

High

1251696

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

High-throughput

0.493

High

234134

FADS1
Acyl-CoA

1

1

High-throughput

0.489

High

505517

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

1

High-throughput

0.489

High

558758

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

1

High-throughput

0.489

High

674770

AA1R
Adenosine receptor A1

1

1

High-throughput

0.489

High

1067543

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

1115479

SV2C
Synaptic vesicle glycoprotein 2C

1

1

High-throughput

0.489

High

1147580

SE1L3
Protein sel-1 homolog 3

1

1

High-throughput

0.489

High

1245419

OR6M1
Olfactory receptor 6M1

1

1

High-throughput

0.489

High

1245422

OR6T1
Olfactory receptor 6T1

1

1

High-throughput

0.489

High

1251724

SC5A4
Probable glucose sensor protein SLC5A4

1

1

High-throughput

0.489

High

1251731

CP8B1
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

1

1

High-throughput

0.489

High

1251735

O10H1
Olfactory receptor 10H1

1

1

High-throughput

0.489

High

1251737

FADS3
Fatty acid desaturase 3

1

1

High-throughput

0.489

High

894233

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

976482

ERCC6
DNA excision repair protein ERCC-6

1

0

High-throughput

0.480

High

1028400

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

0

Small-scale

0.480

High

1138841

OTU1
Ubiquitin thioesterase OTU1

1

1

Small-scale

0.479

High

1251693

ZFN2B
AN1-type zinc finger protein 2B

1

1

Small-scale

0.479

High

1251700

RN185
E3 ubiquitin-protein ligase RNF185

1

1

High-throughput

0.479

High

1251702

IFT74
Intraflagellar transport protein 74 homolog

1

1

High-throughput

0.479

High

1251711

UBXN6
UBX domain-containing protein 6

1

1

Small-scale

0.479

High

1251713

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

1

Small-scale

0.479

High

1251718

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

Small-scale

0.479

High

1251725

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.479

High

1251728

HERC5
E3 ISG15--protein ligase HERC5

1

2

Small-scale

0.479

High

244685

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

285167

DXO
Decapping and exoribonuclease protein

1

0

Small-scale

0.458

High

295044

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

360190

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

387154

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

429089

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

543044

GLNA
Glutamine synthetase

1

0

Small-scale

0.458

High

639779

IKBA
NF-kappa-B inhibitor alpha

1

0

Small-scale

0.458

High

654578

CALX
Calnexin

1

0

High-throughput

0.458

High

673418

MPIP1
M-phase inducer phosphatase 1

1

0

Small-scale

0.458

High

720968

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

779777

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

832592

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

847567

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

877214

ADK
Adenosine kinase

1

0

High-throughput

0.458

High

1019034

TP53B
TP53-binding protein 1

1

0

Small-scale

0.458

High

1049091

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

1051375

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

1064509

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1075805

CIP4
Cdc42-interacting protein 4

1

0

High-throughput

0.458

High

1132530

UBX11
UBX domain-containing protein 11

1

0

High-throughput

0.458

High

1200508

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1240024

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.458

High

1245498

SVIP
Small VCP/p97-interacting protein

1

0

Small-scale

0.458

High

1251692

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.458

High

1251694

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

1251697

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1251705

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.458

High

1251706

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

1251708

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1251709

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1251712

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.458

High

1251716

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1251717

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1251719

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1251726

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1251733

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.458

High

1251736

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

0

Small-scale

0.458

High

965765

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1170914

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1251714

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

135273

E2F3
Transcription factor E2F3

1

0

Small-scale

0.426

High

575796

VINC
Vinculin

1

0

High-throughput

0.426

High

1130352

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

92793

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

1241535

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

1251704

KCNKG
Potassium channel subfamily K member 16

3

0

High-throughput

0.347

High

1188313

ATG9A
Autophagy-related protein 9A

2

0

High-throughput

0.328

High

1002123

TMM62
Transmembrane protein 62

2

0

High-throughput

0.318

High

49477

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

299189

CSCL1
CSC1-like protein 1

1

0

High-throughput

0.279

Low

946413

EREP3
Protein ENTREP3

1

0

High-throughput

0.279

Low

1127816

LRC73
Leucine-rich repeat-containing protein 73

1

0

High-throughput

0.279

Low

1128823

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

1239930

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1251715

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.279

Low

1251721

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.279

Low

836355

GRAK
Granzyme K

1

0

Small-scale

0.261

Low

47949

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.249

Low

100984

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

385203

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

514707

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.249

Low

1172684

CE128
Centrosomal protein of 128 kDa

1

0

High-throughput

0.249

Low

1224598

S38A6
Solute carrier family 38 member 6

1

0

High-throughput

0.249

Low

1230289

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1231280

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1251698

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

High-throughput

0.249

Low

1251720

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1251723

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024