Protein: TRIM5
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)

Gene: TRIM5
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q9C035

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000932 - P-body
GO:0002218 - activation of innate immune response
GO:0003713 - transcription coactivator activity
GO:0004842 - ubiquitin-protein transferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1318711

TRIM5
Tripartite motif-containing protein 5

15

16

Small-scale

0.985

High

896370

UBE2K
Ubiquitin-conjugating enzyme E2 K

4

20

High-throughput

0.892

High

896538

UBE2N
Ubiquitin-conjugating enzyme E2 N

3

20

Small-scale

0.878

High

1317000

TRI34
E3 ubiquitin-protein ligase TRIM34

3

16

Small-scale

0.865

High

919853

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.864

High

895905

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

Small-scale

0.857

High

1318709

TRIM6
Tripartite motif-containing protein 6

2

17

Small-scale

0.767

High

1318716

UBQL2
Ubiquilin-2

2

11

High-throughput

0.754

High

1023330

TRI32
E3 ubiquitin-protein ligase TRIM32

1

18

High-throughput

0.733

High

849439

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

High-throughput

0.698

High

909086

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

1023555

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

2

High-throughput

0.698

High

1033141

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

1079017

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.698

High

1138920

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1318719

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

70489

B2RNG4
TRIM6-TRIM34 readthrough

1

17

High-throughput

0.691

High

476330

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

Small-scale

0.647

High

585058

RO52
E3 ubiquitin-protein ligase TRIM21

1

16

Small-scale

0.647

High

1284884

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

Small-scale

0.647

High

1318718

TRI35
E3 ubiquitin-protein ligase TRIM35

1

16

Small-scale

0.647

High

529691

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.633

High

475177

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

12

Small-scale

0.621

High

1171602

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1308862

DDX50
ATP-dependent RNA helicase DDX50

1

5

High-throughput

0.618

High

213639

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

6

High-throughput

0.606

High

433465

YES
Tyrosine-protein kinase Yes

2

8

High-throughput

0.606

High

883386

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

9

High-throughput

0.606

High

1132889

MPP7
MAGUK p55 subfamily member 7

2

3

High-throughput

0.606

High

1232312

MTURN
Maturin

2

2

High-throughput

0.606

High

1293263

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

2

High-throughput

0.606

High

870688

SYYC
Tyrosine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.602

High

730349

PRS7
26S proteasome regulatory subunit 7

1

6

Small-scale

0.573

High

572448

LEG3
Galectin-3

1

13

Small-scale

0.561

High

1110205

T10IP
Testis-specific protein 10-interacting protein

2

2

High-throughput

0.553

High

851282

MAT1
CDK-activating kinase assembly factor MAT1

1

7

High-throughput

0.541

High

967414

EWS
RNA-binding protein EWS

1

7

High-throughput

0.541

High

1078906

ITSN1
Intersectin-1

1

2

High-throughput

0.541

High

471649

TFPT
TCF3 fusion partner

1

1

High-throughput

0.536

High

556963

CREB1
Cyclic AMP-responsive element-binding protein 1

1

3

High-throughput

0.536

High

1190752

DCXR
L-xylulose reductase

1

2

High-throughput

0.536

High

1285063

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.536

High

72161

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

900068

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.518

High

308017

ZWINT
ZW10 interactor

1

3

High-throughput

0.515

High

995585

ECHP
Peroxisomal bifunctional enzyme

1

4

High-throughput

0.515

High

1318720

SHLB1
Endophilin-B1

1

4

High-throughput

0.515

High

121211

LEG8
Galectin-8

1

13

Small-scale

0.501

High

278162

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

Small-scale

0.501

High

397179

KPCG
Protein kinase C gamma type

1

9

Small-scale

0.501

High

928187

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.501

High

1235454

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

4

High-throughput

0.494

High

1224834

FAM9C
Protein FAM9C

1

2

High-throughput

0.489

High

271189

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

20

High-throughput

0.481

High

599727

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

High-throughput

0.481

High

800627

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

20

High-throughput

0.481

High

1121195

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

20

High-throughput

0.481

High

1318713

TBA8
Tubulin alpha-8 chain

1

9

High-throughput

0.481

High

1318717

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

14

High-throughput

0.481

High

1318721

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

17

High-throughput

0.481

High

964424

RUNX1
Runt-related transcription factor 1

1

0

Small-scale

0.480

High

163239

XPO1
Exportin-1

1

1

High-throughput

0.479

High

181892

SOCS1
Suppressor of cytokine signaling 1

1

11

Small-scale

0.479

High

201427

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

8

Small-scale

0.479

High

255198

ATG13
Autophagy-related protein 13

1

2

Small-scale

0.479

High

309041

KI20A
Kinesin-like protein KIF20A

1

17

High-throughput

0.479

High

326772

SNAI1
Zinc finger protein SNAI1

1

20

Small-scale

0.479

High

798752

PRS6B
26S proteasome regulatory subunit 6B

1

6

Small-scale

0.479

High

849266

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

2

Small-scale

0.479

High

907150

PRS8
26S proteasome regulatory subunit 8

1

8

Small-scale

0.479

High

1028428

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

6

Small-scale

0.479

High

1036876

SQSTM
Sequestosome-1

1

7

Small-scale

0.479

High

1042482

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1045315

NCOA4
Nuclear receptor coactivator 4

1

1

Small-scale

0.479

High

1066647

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

1083520

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

2

Small-scale

0.479

High

1234340

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

9

Small-scale

0.479

High

1255682

RBCC1
RB1-inducible coiled-coil protein 1

1

13

Small-scale

0.479

High

1305243

PHB2
Prohibitin-2

1

5

Small-scale

0.479

High

1318714

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

10

Small-scale

0.479

High

1318715

DAXX
Death domain-associated protein 6

1

3

Small-scale

0.479

High

1318722

NEMO
NF-kappa-B essential modulator

1

13

Small-scale

0.479

High

527776

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.470

High

254415

N4BP1
NEDD4-binding protein 1

1

0

Small-scale

0.458

High

789978

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

Small-scale

0.458

High

1185439

OTU6A
OTU domain-containing protein 6A

1

3

High-throughput

0.439

High

1288093

OTUB2
Ubiquitin thioesterase OTUB2

1

4

High-throughput

0.439

High

1318712

CUED1
CUE domain-containing protein 1

2

0

High-throughput

0.328

High

259470

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

886330

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024