Protein: SETD7
Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9)

Gene: SETD7
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q8WTS6

Gene Ontology (top 5):
GO:0002039 - p53 binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998583

H31
Histone H3.1

6

4

Small-scale

0.953

High

980038

H4
Histone H4

2

1

Small-scale

0.778

High

1161959

H31T
Histone H3.1t

2

4

Small-scale

0.778

High

414286

P53
Cellular tumor antigen p53

8

3

Small-scale

0.755

High

1355984

SETD7
Histone-lysine N-methyltransferase SETD7

2

9

Small-scale

0.755

High

1355988

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

2

Small-scale

0.747

High

1162846

H2A2C
Histone H2A type 2-C

1

2

High-throughput

0.691

High

623460

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.687

High

1045564

TF65
Transcription factor p65

4

0

Small-scale

0.682

High

685035

DNMT1
DNA

2

2

Small-scale

0.666

High

1017051

H33
Histone H3.3

1

4

Small-scale

0.647

High

1029118

E2F1
Transcription factor E2F1

3

0

Small-scale

0.627

High

1227140

A16L1
Autophagy-related protein 16-1

1

0

Small-scale

0.625

High

1091636

TAF10
Transcription initiation factor TFIID subunit 10

2

0

Small-scale

0.622

High

396586

ESR1
Estrogen receptor

2

5

Small-scale

0.602

High

1355989

RIOK1
Serine/threonine-protein kinase RIO1

1

1

Small-scale

0.578

High

1355985

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.578

High

1149855

TAF7
Transcription initiation factor TFIID subunit 7

2

0

Small-scale

0.569

High

1355987

NR1H4
Bile acid receptor

1

5

Small-scale

0.562

High

581698

MYOD1
Myoblast determination protein 1

1

1

Small-scale

0.561

High

872570

SOX2
Transcription factor SOX-2

1

4

Small-scale

0.561

High

1355986

OTUB1
Ubiquitin thioesterase OTUB1

1

1

Small-scale

0.561

High

827860

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.554

High

1355993

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.549

High

1355994

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

Small-scale

0.537

High

528310

THIO
Thioredoxin

1

1

High-throughput

0.536

High

607620

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

2

High-throughput

0.536

High

1085594

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.536

High

1355995

ARI1
E3 ubiquitin-protein ligase ARIH1

1

2

High-throughput

0.536

High

290962

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.513

High

423682

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

456805

ANXA2
Annexin A2

1

0

High-throughput

0.513

High

596260

H12
Histone H1.2

1

0

High-throughput

0.513

High

729592

CASPE
Caspase-14

1

0

High-throughput

0.513

High

1118229

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

171287

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

3

Small-scale

0.501

High

177698

SMAD7
Mothers against decapentaplegic homolog 7

1

2

Small-scale

0.501

High

185879

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

216965

KLF4
Krueppel-like factor 4

1

3

Small-scale

0.501

High

508331

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

169122

ML12B
Myosin regulatory light chain 12B

1

9

High-throughput

0.489

High

952610

MYL6
Myosin light polypeptide 6

1

6

High-throughput

0.489

High

665120

COT2
COUP transcription factor 2

1

2

High-throughput

0.481

High

1028303

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.480

High

242391

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

520222

ANDR
Androgen receptor

1

4

Small-scale

0.479

High

1252757

RN111
E3 ubiquitin-protein ligase Arkadia

1

3

Small-scale

0.479

High

1331457

ZFP41
Zinc finger protein 41 homolog

1

10

High-throughput

0.479

High

1355990

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

5

Small-scale

0.479

High

1355991

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

5

Small-scale

0.479

High

1355992

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

320734

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

551175

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

628816

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

892053

TAF6
Transcription initiation factor TFIID subunit 6

1

0

Small-scale

0.458

High

903429

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

0

Small-scale

0.458

High

1161332

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

407010

A1BG
Alpha-1B-glycoprotein

1

1

High-throughput

0.439

High

375765

RASK
GTPase KRas

1

6

High-throughput

0.437

High

720684

AGTR1
Type-1 angiotensin II receptor

1

3

High-throughput

0.437

High

733402

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.437

High

1065742

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

6

High-throughput

0.437

High

1210924

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.437

High

369191

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

442769

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.426

High

894433

MMP14
Matrix metalloproteinase-14

1

0

High-throughput

0.426

High

1150339

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

1

0

High-throughput

0.426

High

1211867

CHCH9
Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial

1

0

High-throughput

0.426

High

868563

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.279

Low

1010679

DCD
Dermcidin

1

0

High-throughput

0.279

Low

1062272

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.279

Low

531114

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

0

High-throughput

0.251

Low

1225900

STEA3
Metalloreductase STEAP3

1

0

High-throughput

0.251

Low

106344

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1010503

EREP3
Protein ENTREP3

1

0

High-throughput

0.249

Low

250942

TPST1
Protein-tyrosine sulfotransferase 1

1

0

High-throughput

0.232

Low

404854

PRIO
Major prion protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025