Protein: ROK1
ATP-dependent RNA helicase ROK1 (EC 3.6.4.13) (Rescuer of KEM1 protein 1)

Gene: ROK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 125
UniProt ID: P45818

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678411

PWP2
Periodic tryptophan protein 2

3

12

High-throughput

0.855

High

852597

UTP15
U3 small nucleolar RNA-associated protein 15

2

10

High-throughput

0.789

High

852606

SGD1
Suppressor of glycerol defect protein 1

2

7

Small-scale

0.768

High

852596

DHR1
Probable ATP-dependent RNA helicase DHR1

2

11

High-throughput

0.754

High

852613

UTP4
U3 small nucleolar RNA-associated protein 4

2

10

Small-scale

0.754

High

798249

ENP1
Essential nuclear protein 1

6

4

Small-scale

0.719

High

852581

UTP22
U3 small nucleolar RNA-associated protein 22

5

0

High-throughput

0.692

High

852599

RRP5
rRNA biogenesis protein RRP5

4

8

Small-scale

0.689

High

677458

KRR1
KRR1 small subunit processome component

3

3

High-throughput

0.640

High

844507

UTP10
U3 small nucleolar RNA-associated protein 10

3

3

High-throughput

0.640

High

852592

UTP6
U3 small nucleolar RNA-associated protein 6

3

0

High-throughput

0.628

High

632696

DBP4
ATP-dependent RNA helicase HCA4

1

16

High-throughput

0.618

High

633173

MAK11
Protein MAK11

1

17

Small-scale

0.618

High

754298

DCA13
Protein SOF1

1

11

High-throughput

0.618

High

782077

RL1D1
Ribosome biogenesis protein UTP30

1

1

High-throughput

0.618

High

817587

UTP7
U3 small nucleolar RNA-associated protein 7

1

8

High-throughput

0.618

High

852572

MTR4
ATP-dependent RNA helicase DOB1

1

14

High-throughput

0.618

High

852576

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.618

High

852593

UTP17
NET1-associated nuclear protein 1

1

8

High-throughput

0.618

High

852601

HRQ1
ATP-dependent helicase HRQ1

1

17

Small-scale

0.618

High

852603

UTP13
U3 small nucleolar RNA-associated protein 13

1

18

High-throughput

0.618

High

852610

RRP9
Ribosomal RNA-processing protein 9

1

17

High-throughput

0.618

High

852629

DBP10
ATP-dependent RNA helicase DBP10

1

18

High-throughput

0.618

High

852624

FAL1
ATP-dependent RNA helicase FAL1

1

18

Small-scale

0.590

High

852625

SAS10
Something about silencing protein 10

2

0

High-throughput

0.588

High

823349

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.586

High

852586

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.586

High

672907

RRP43
Exosome complex component RRP43

2

2

High-throughput

0.584

High

852598

UTP14
U3 small nucleolar RNA-associated protein 14

2

1

High-throughput

0.584

High

852604

UTP21
U3 small nucleolar RNA-associated protein 21

2

8

Small-scale

0.584

High

852611

NOC4
Nucleolar complex protein 4

2

5

High-throughput

0.584

High

852632

NOP58
Nucleolar protein 58

2

6

High-throughput

0.584

High

852574

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

0

Small-scale

0.559

High

792111

GBLP
Small ribosomal subunit protein RACK1

1

14

High-throughput

0.553

High

545329

SSB1
Ribosome-associated molecular chaperone SSB1

2

11

High-throughput

0.552

High

531789

RL4A
Large ribosomal subunit protein uL4A

1

3

High-throughput

0.536

High

655478

RS3A2
Small ribosomal subunit protein eS1B

1

5

High-throughput

0.536

High

709413

HRR25
Casein kinase I homolog HRR25

1

3

Small-scale

0.536

High

852605

MRD1
Multiple RNA-binding domain-containing protein 1

1

6

Small-scale

0.536

High

503111

RS22A
Small ribosomal subunit protein uS8A

2

4

High-throughput

0.533

High

852628

UTP23
rRNA-processing protein UTP23

1

3

Small-scale

0.501

High

677937

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.493

High

511816

RS24A
Small ribosomal subunit protein eS24A

1

2

High-throughput

0.489

High

762978

SPT7
SAGA complex subunit SPT7

1

14

High-throughput

0.489

High

149829

RS9A
Small ribosomal subunit protein uS4A

1

5

High-throughput

0.479

High

436031

RS13
Small ribosomal subunit protein uS15

1

5

High-throughput

0.479

High

441982

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

455126

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.479

High

512507

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.479

High

513079

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

514695

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.479

High

579618

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

585303

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

High-throughput

0.479

High

670861

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

674693

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.479

High

735040

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

747024

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

5

High-throughput

0.479

High

747437

RSSA1
Small ribosomal subunit protein uS2A

1

7

High-throughput

0.479

High

752418

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.479

High

753440

RS3A1
Small ribosomal subunit protein eS1A

1

5

High-throughput

0.479

High

808283

RRP8
25S rRNA

1

1

High-throughput

0.479

High

814337

NOC2
Nucleolar complex protein 2

1

1

High-throughput

0.479

High

852573

NOP9
Nucleolar protein 9

1

1

Small-scale

0.479

High

852578

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.479

High

852582

RRP46
Exosome complex component RRP46

1

1

High-throughput

0.479

High

852583

PESC
Pescadillo homolog

1

4

High-throughput

0.479

High

852587

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.479

High

852589

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.479

High

852591

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

852594

TOM1
E3 ubiquitin-protein ligase TOM1

1

13

High-throughput

0.479

High

852595

UTP5
U3 small nucleolar RNA-associated protein 5

1

10

High-throughput

0.479

High

852600

FCF1
rRNA-processing protein FCF1

1

3

High-throughput

0.479

High

852616

RCL1
rRNA processing protein RCL1

1

1

High-throughput

0.479

High

852617

RRP44
Exosome complex exonuclease DIS3

1

5

High-throughput

0.479

High

852621

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

852622

BMS1
Ribosome biogenesis protein BMS1

1

3

High-throughput

0.479

High

852626

RIO1
Serine/threonine-protein kinase RIO1

1

9

High-throughput

0.479

High

852627

UTP12
U3 small nucleolar RNA-associated protein 12

1

11

High-throughput

0.479

High

852630

NOP56
Nucleolar protein 56

1

6

High-throughput

0.479

High

673195

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

758382

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

763581

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

806534

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

818314

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

825057

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

825532

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

826190

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

852575

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

852580

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

852584

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

852585

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.458

High

852602

RRP45
Exosome complex component RRP45

1

0

High-throughput

0.458

High

852608

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

852609

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

852612

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

852615

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

852620

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

852623

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

852631

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

852633

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

852634

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.458

High

852635

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

524341

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

804249

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

819089

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

383765

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.437

High

511222

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

558777

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

694576

SPT5
Transcription elongation factor SPT5

1

4

High-throughput

0.437

High

707450

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

745789

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.437

High

812425

LAA1
AP-1 accessory protein LAA1

1

4

High-throughput

0.437

High

826021

ULP2
Ubiquitin-like-specific protease 2

1

4

High-throughput

0.437

High

826606

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.437

High

852588

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.437

High

852590

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.437

High

852607

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

852614

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.437

High

852619

SGO1
Shugoshin

1

3

High-throughput

0.437

High

852618

RBX1
RING-box protein HRT1

1

4

High-throughput

0.417

High

852579

ARI1
NADPH-dependent aldehyde reductase ARI1

1

0

High-throughput

0.269

Low

802794

OSH3
Oxysterol-binding protein homolog 3

1

0

Small-scale

0.264

Low

748448

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

792361

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.249

Low

852577

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025