Protein: MAK11
Protein MAK11 (Maintenance of killer protein 11)

Gene: MAK11
Organism: Saccharomyces cerevisiae S288C
Interactions: 92
UniProt ID: P20484

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0004860 - protein kinase inhibitor activity
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

633179

PESC
Pescadillo homolog

5

3

Small-scale

0.915

High

633185

HAS1
ATP-dependent RNA helicase HAS1

4

20

Small-scale

0.867

High

633189

ERB1
Ribosome biogenesis protein ERB1

3

18

Small-scale

0.847

High

633204

YTM1
Ribosome biogenesis protein YTM1

3

18

Small-scale

0.817

High

633132

MAK11
Protein MAK11

2

17

Small-scale

0.754

High

633145

DRS1
ATP-dependent RNA helicase DRS1

2

20

Small-scale

0.754

High

633154

MAK5
ATP-dependent RNA helicase MAK5

2

20

Small-scale

0.754

High

633193

DBP9
ATP-dependent RNA helicase DBP9

2

20

Small-scale

0.754

High

633199

RLP24
Ribosome biogenesis protein RLP24

5

5

Small-scale

0.699

High

633195

RRP15
Ribosomal RNA-processing protein 15

4

1

Small-scale

0.696

High

633170

NOP2
25S rRNA

4

4

Small-scale

0.686

High

633210

IF6
Eukaryotic translation initiation factor 6

4

1

Small-scale

0.686

High

633176

NSA1
Ribosome biogenesis protein NSA1

4

1

Small-scale

0.672

High

633156

CIC1
Proteasome-interacting protein CIC1

3

5

Small-scale

0.640

High

633169

RLP7
Ribosome biogenesis protein RLP7

3

7

Small-scale

0.640

High

633152

RPF2
Ribosome biogenesis protein RPF2

3

2

Small-scale

0.633

High

633134

SPB1
27S pre-rRNA

1

8

High-throughput

0.618

High

633137

SPB4
ATP-dependent rRNA helicase SPB4

1

20

High-throughput

0.618

High

633151

DBP7
ATP-dependent RNA helicase DBP7

1

20

Small-scale

0.618

High

633173

ROK1
ATP-dependent RNA helicase ROK1

1

17

Small-scale

0.618

High

633180

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

20

High-throughput

0.618

High

633208

DBP10
ATP-dependent RNA helicase DBP10

1

20

High-throughput

0.618

High

633159

RPF1
Ribosome production factor 1

3

0

Small-scale

0.606

High

534081

MAK16
Protein MAK16

2

2

Small-scale

0.584

High

633146

MRT4
Ribosome assembly factor MRT4

2

10

Small-scale

0.584

High

633148

RRP1
Ribosomal RNA-processing protein 1

2

6

Small-scale

0.584

High

633149

EBP2
rRNA-processing protein EBP2

2

3

Small-scale

0.584

High

633157

SSF1
Ribosome biogenesis protein SSF1

2

4

Small-scale

0.584

High

633160

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

8

Small-scale

0.584

High

633163

NOC2
Nucleolar complex protein 2

2

1

Small-scale

0.584

High

633182

NOP15
Ribosome biogenesis protein 15

2

20

Small-scale

0.584

High

633183

NOG1
Nucleolar GTP-binding protein 1

2

7

Small-scale

0.584

High

633192

FKBP4
FK506-binding protein 4

2

6

Small-scale

0.584

High

633198

NOC3
Nucleolar complex-associated protein 3

2

3

Small-scale

0.584

High

633201

BRX1
Ribosome biogenesis protein BRX1

2

10

Small-scale

0.584

High

633203

NIP7
60S ribosome subunit biogenesis protein NIP7

2

1

Small-scale

0.584

High

633187

PUF6
Pumilio homology domain family member 6

2

3

Small-scale

0.571

High

633190

RRP5
rRNA biogenesis protein RRP5

2

17

Small-scale

0.571

High

633150

RRP14
Ribosomal RNA-processing protein 14

2

0

Small-scale

0.559

High

633165

NOP16
Nucleolar protein 16

2

0

Small-scale

0.559

High

633172

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

0

Small-scale

0.559

High

633144

TOR2
Serine/threonine-protein kinase TOR2

1

11

High-throughput

0.553

High

633147

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

6

Small-scale

0.553

High

394231

EF1A
Elongation factor 1-alpha

2

5

High-throughput

0.533

High

633161

MET30
F-box protein MET30

1

18

High-throughput

0.528

High

633141

XPO1
Exportin-1

1

11

High-throughput

0.489

High

633175

HUL5
E3 ubiquitin-protein ligase HUL5

1

13

High-throughput

0.489

High

569903

RL3
Large ribosomal subunit protein uL3

1

8

High-throughput

0.479

High

585204

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

5

Small-scale

0.479

High

633138

RL16A
Large ribosomal subunit protein uL13A

1

8

High-throughput

0.479

High

633153

NOP4
Nucleolar protein 4

1

15

High-throughput

0.479

High

633155

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.479

High

633164

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

6

Small-scale

0.479

High

633166

NUG1
Nuclear GTP-binding protein NUG1

1

10

High-throughput

0.479

High

633171

UTP10
U3 small nucleolar RNA-associated protein 10

1

5

High-throughput

0.479

High

633178

UTP22
U3 small nucleolar RNA-associated protein 22

1

2

Small-scale

0.479

High

633181

NOP13
Nucleolar protein 13

1

20

High-throughput

0.479

High

633184

TOM1
E3 ubiquitin-protein ligase TOM1

1

11

High-throughput

0.479

High

633188

UTP14
U3 small nucleolar RNA-associated protein 14

1

10

High-throughput

0.479

High

633196

NOC4
Nucleolar complex protein 4

1

7

High-throughput

0.479

High

633200

NOP12
Nucleolar protein 12

1

19

Small-scale

0.479

High

633202

RRS1
Regulator of ribosome biosynthesis

1

3

High-throughput

0.479

High

633205

SSF2
Ribosome biogenesis protein SSF2

1

4

High-throughput

0.479

High

633206

MAK21
Ribosome biogenesis protein MAK21

1

7

High-throughput

0.479

High

633209

NOP56
Nucleolar protein 56

1

8

Small-scale

0.479

High

633135

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

633133

XRN1
5'-3' exoribonuclease 1

1

3

High-throughput

0.457

High

409687

RL24A
Large ribosomal subunit protein eL24A

1

5

Small-scale

0.437

High

513326

RL23B
Large ribosomal subunit protein uL14B

1

2

High-throughput

0.437

High

514454

RS18A
Small ribosomal subunit protein uS13A

1

4

High-throughput

0.437

High

578830

HSC82
ATP-dependent molecular chaperone HSC82

1

16

High-throughput

0.437

High

624714

PMA2
Plasma membrane ATPase 2

1

5

High-throughput

0.437

High

633136

CDC48
Cell division control protein 48

1

14

High-throughput

0.437

High

633139

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

633140

BMH1
Protein BMH1

1

8

High-throughput

0.437

High

633142

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.437

High

633143

SPT16
FACT complex subunit SPT16

1

8

High-throughput

0.437

High

633162

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

633168

ULP2
Ubiquitin-like-specific protease 2

1

7

High-throughput

0.437

High

633177

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.437

High

633186

VMS1
tRNA endonuclease VMS1

1

2

High-throughput

0.437

High

633191

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

513456

RL1A
Large ribosomal subunit protein uL1A

1

9

Small-scale

0.407

High

523033

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.407

High

633167

SSB2
Ribosome-associated molecular chaperone SSB2

1

17

High-throughput

0.407

High

633174

RL4B
Large ribosomal subunit protein uL4B

1

6

High-throughput

0.407

High

633207

HSP42
Heat shock protein 42

1

4

High-throughput

0.407

High

558578

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

633158

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.249

Low

633194

BCP1
Protein BCP1

1

0

High-throughput

0.249

Low

633197

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025