Protein: MCFD2
Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein)

Gene: MCFD2
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q8NI22

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
GO:0012507 - ER to Golgi transport vesicle membrane
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

880618

LMAN1
Protein ERGIC-53

8

0

Small-scale

0.922

High

144456

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

928870

LIPR1
Inactive pancreatic lipase-related protein 1

2

0

High-throughput

0.580

High

1007404

S35A1
CMP-sialic acid transporter

2

0

High-throughput

0.580

High

535316

BIP
Endoplasmic reticulum chaperone BiP

2

0

High-throughput

0.576

High

1340951

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.575

High

1340962

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.575

High

1009861

NUCB2
Nucleobindin-2

1

0

High-throughput

0.546

High

1145628

RCN1
Reticulocalbin-1

1

0

High-throughput

0.546

High

1340954

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.546

High

921965

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

1340974

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.536

High

158267

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

331164

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.513

High

938247

SEC13
Protein SEC13 homolog

1

0

High-throughput

0.513

High

964038

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.513

High

1340947

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

1340972

KLHL9
Kelch-like protein 9

1

1

High-throughput

0.489

High

1340973

KLH13
Kelch-like protein 13

1

1

High-throughput

0.489

High

319004

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.481

High

567037

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.481

High

876940

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.481

High

1340969

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.481

High

422662

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

218509

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

48710

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.445

High

275540

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

328959

RTN3
Reticulon-3

1

2

High-throughput

0.445

High

333109

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.445

High

697964

CALR
Calreticulin

1

1

High-throughput

0.445

High

698919

CALX
Calnexin

1

1

High-throughput

0.445

High

773576

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.445

High

888930

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.445

High

1146586

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

1199220

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.445

High

1316262

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

1340077

ATLA2
Atlastin-2

1

2

High-throughput

0.445

High

1340946

ATLA1
Atlastin-1

1

2

High-throughput

0.445

High

1340955

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.445

High

1340964

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

1340971

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.445

High

1340977

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.445

High

1340978

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

1340980

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

50629

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.426

High

60381

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

211826

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

215610

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.426

High

283315

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

360047

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

873275

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

904018

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.426

High

921726

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

987127

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

1015069

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.426

High

1131328

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

1136284

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

1139229

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

1139352

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

1147802

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

1152825

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

1248634

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

1327900

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

1330319

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.426

High

1337603

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.426

High

1340945

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.426

High

1340948

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.426

High

1340949

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

1340956

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

1340959

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.426

High

1340961

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

1340965

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

1340970

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

104355

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.407

High

1333909

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.407

High

1340975

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.407

High

1031671

ILRL1
Interleukin-1 receptor-like 1

2

0

High-throughput

0.316

High

1142104

P2RY6
P2Y purinoceptor 6

2

0

High-throughput

0.316

High

1324332

SYS1
Protein SYS1 homolog

2

0

High-throughput

0.316

High

1340950

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

0

High-throughput

0.316

High

1180372

HKDC1
Hexokinase HKDC1

1

0

High-throughput

0.279

Low

441557

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

562249

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

1340976

SHLB1
Endophilin-B1

1

0

High-throughput

0.268

Low

1135558

CLCA4
Calcium-activated chloride channel regulator 4

1

0

High-throughput

0.251

Low

704544

RXRB
Retinoic acid receptor RXR-beta

1

0

High-throughput

0.249

Low

1340958

UBXN6
UBX domain-containing protein 6

1

0

Small-scale

0.249

Low

142373

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.232

Low

213631

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.232

Low

296532

STAM2
Signal transducing adapter molecule 2

1

0

High-throughput

0.232

Low

462526

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.232

Low

883121

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.232

Low

903743

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.232

Low

1027098

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.232

Low

1097011

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.232

Low

1104020

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1258783

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.232

Low

1338198

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.232

Low

1340952

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

1340953

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.232

Low

1340957

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.232

Low

1340960

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.232

Low

1340963

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

1340966

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.232

Low

1340967

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.232

Low

1340968

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low

1340979

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025