Protein: IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]

Gene: IRE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 155
UniProt ID: P32361

Gene Ontology (top 5):
GO:0004521 - RNA endonuclease activity
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

688729

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

12

18

Small-scale

0.983

High

541645

SEC63
Protein translocation protein SEC63

2

5

Small-scale

0.737

High

560592

BIP
Endoplasmic reticulum chaperone BiP

7

16

Small-scale

0.736

High

688761

PP2C2
Protein phosphatase 2C homolog 2

1

10

Small-scale

0.709

High

688798

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

7

High-throughput

0.656

High

649868

CDC15
Cell division control protein 15

1

18

High-throughput

0.647

High

688740

PP2C1
Protein phosphatase 2C homolog 1

1

9

High-throughput

0.647

High

688742

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

18

High-throughput

0.647

High

688779

AZF1
Transcription factor AZF1

1

2

High-throughput

0.647

High

688791

FPK1
Flippase kinase 1

1

8

High-throughput

0.647

High

688843

YP150
Putative serine/threonine-protein kinase YPL150W

1

17

High-throughput

0.647

High

341088

CBPY
Carboxypeptidase Y

2

4

Small-scale

0.624

High

434743

PBS2
MAP kinase kinase PBS2

1

18

High-throughput

0.618

High

688738

PIN4
RNA-binding protein PIN4

1

1

High-throughput

0.618

High

688751

RCK2
Serine/threonine-protein kinase RCK2

1

19

High-throughput

0.618

High

688772

FKH1
Fork head protein homolog 1

1

3

High-throughput

0.618

High

688808

TDA1
Serine/threonine-protein kinase TDA1

1

20

High-throughput

0.618

High

688851

SKM1
Serine/threonine-protein kinase SKM1

1

16

High-throughput

0.618

High

688855

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.614

High

688821

RRP5
rRNA biogenesis protein RRP5

1

5

High-throughput

0.579

High

365964

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.575

High

688776

DJP1
DnaJ-like protein 1

1

10

High-throughput

0.575

High

688807

GCN5
Histone acetyltransferase GCN5

1

6

Small-scale

0.573

High

688824

DCR2
Phosphatase DCR2

1

0

Small-scale

0.572

High

510585

SSB1
Ribosome-associated molecular chaperone SSB1

2

14

High-throughput

0.571

High

688766

SSB2
Ribosome-associated molecular chaperone SSB2

2

14

High-throughput

0.571

High

688768

SECU
Securin

1

1

High-throughput

0.536

High

520235

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.518

High

426434

SYSC
Serine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

621994

SSD1
Protein SSD1

1

2

High-throughput

0.501

High

687782

MSB2
Signaling mucin MSB2

1

3

Small-scale

0.501

High

688730

PAH1
Phosphatidic acid phosphohydrolase 1

1

1

High-throughput

0.501

High

688733

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

3

High-throughput

0.501

High

688736

SGE1
Protein SGE1

1

8

High-throughput

0.501

High

688752

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

8

High-throughput

0.501

High

688759

HPH2
Protein HPH2

1

1

High-throughput

0.501

High

688769

VPS27
Vacuolar protein sorting-associated protein 27

1

3

High-throughput

0.501

High

688781

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

688786

PHO23
Transcriptional regulatory protein PHO23

1

3

High-throughput

0.501

High

688787

SKP1
Suppressor of kinetochore protein 1

1

4

High-throughput

0.501

High

688801

ADA2
Transcriptional adapter 2

1

1

Small-scale

0.501

High

688802

TBF1
Protein TBF1

1

1

High-throughput

0.501

High

688822

HEL2
E3 ubiquitin-protein ligase HEL2

1

1

High-throughput

0.501

High

688833

NVJ2
Nucleus-vacuole junction protein 2

1

1

High-throughput

0.501

High

688836

BDF2
Bromodomain-containing factor 2

1

4

High-throughput

0.501

High

688842

SAS10
Something about silencing protein 10

1

1

High-throughput

0.501

High

688841

HOSM
Homocitrate synthase, mitochondrial

1

0

High-throughput

0.493

High

549037

TRM1
tRNA

1

0

High-throughput

0.480

High

606576

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.480

High

688746

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.480

High

688748

YB47
Uncharacterized protein YBR197C

1

0

High-throughput

0.480

High

688762

ARB1
ABC transporter ATP-binding protein ARB1

1

0

High-throughput

0.480

High

688780

PRM10
Pheromone-regulated membrane protein 10

1

0

High-throughput

0.480

High

688785

SPT20
Transcription factor SPT20

1

0

Small-scale

0.480

High

688792

SQS1
Protein SQS1

1

0

High-throughput

0.480

High

688793

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.480

High

688803

RNT1
Ribonuclease 3

1

0

High-throughput

0.480

High

688813

YAP6
AP-1-like transcription factor YAP6

1

0

High-throughput

0.480

High

688839

HFI1
Transcriptional coactivator HFI1/ADA1

1

0

High-throughput

0.480

High

688844

YRR1
Zinc finger transcription factor YRR1

1

0

High-throughput

0.480

High

520060

BAR1
Barrierpepsin

1

1

High-throughput

0.479

High

616104

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

1

5

High-throughput

0.479

High

638675

SPB4
ATP-dependent rRNA helicase SPB4

1

6

High-throughput

0.479

High

688735

SC61A
Protein transport protein SEC61

1

3

High-throughput

0.479

High

688745

RDH54
DNA repair and recombination protein RDH54

1

2

High-throughput

0.479

High

688764

DOT6
Transcriptional regulatory protein DOT6

1

1

High-throughput

0.479

High

688770

NDC80
Kinetochore protein NDC80

1

15

High-throughput

0.479

High

688777

CBF3B
Centromere DNA-binding protein complex CBF3 subunit B

1

1

High-throughput

0.479

High

688778

NOP2
25S rRNA

1

2

High-throughput

0.479

High

688790

PAP2
Poly(A) RNA polymerase protein 2

1

1

High-throughput

0.479

High

688812

ARX1
Probable metalloprotease ARX1

1

1

High-throughput

0.479

High

688825

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

17

High-throughput

0.479

High

688826

DUS3
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]

1

2

High-throughput

0.479

High

688845

RLM1
Transcription factor RLM1

1

1

High-throughput

0.479

High

688846

RIB2
Bifunctional protein RIB2 [Includes: tRNA pseudouridine(32) synthase, cytoplasmic

1

2

High-throughput

0.479

High

529999

STE12
Protein STE12

1

0

High-throughput

0.458

High

688737

MKS1
Negative regulator of RAS-cAMP pathway

1

0

High-throughput

0.458

High

688765

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

688774

VID28
Vacuolar import and degradation protein 28

1

0

High-throughput

0.458

High

688788

SGF73
SAGA-associated factor 73

1

0

High-throughput

0.458

High

688789

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

688796

DAK1
Dihydroxyacetone kinase 1

1

0

High-throughput

0.458

High

688799

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.458

High

688828

LCB5
Sphingoid long chain base kinase 5

1

0

High-throughput

0.458

High

688829

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

688835

SYO1
Synchronized import protein 1

1

0

High-throughput

0.458

High

688840

AEP3
ATPase expression protein 3

1

0

High-throughput

0.458

High

472639

YL21A
Transposon Ty2-LR1 Gag polyprotein

1

10

High-throughput

0.457

High

482558

YA11A
Transposon Ty1-A Gag polyprotein

1

9

High-throughput

0.457

High

482618

YE11A
Transposon Ty1-ER1 Gag polyprotein

1

8

High-throughput

0.457

High

563936

SEC2
Rab guanine nucleotide exchange factor SEC2

1

1

High-throughput

0.457

High

621161

FPS1
Glycerol uptake/efflux facilitator protein

1

11

High-throughput

0.457

High

685404

MLF3
Protein MLF3

1

2

High-throughput

0.457

High

688739

PRX1
Peroxiredoxin PRX1, mitochondrial

1

7

High-throughput

0.457

High

688741

ATG19
Autophagy-related protein 19

1

1

High-throughput

0.457

High

688744

VBA5
Vacuolar basic amino acid transporter 5

1

7

High-throughput

0.457

High

688747

AIM3
Altered inheritance of mitochondria protein 3

1

5

High-throughput

0.457

High

688754

ARN2
Siderophore iron transporter ARN2

1

6

High-throughput

0.457

High

688760

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.457

High

688771

VHS2
Protein VHS2

1

2

High-throughput

0.457

High

688795

AQR1
Probable transporter AQR1

1

6

High-throughput

0.457

High

688809

YM8V
Uncharacterized protein YMR295C

1

1

High-throughput

0.457

High

688814

YM13A
Transposon Ty1-MR1 Gag polyprotein

1

10

High-throughput

0.457

High

688817

HSP31
Glutathione-independent glyoxalase HSP31

1

1

High-throughput

0.457

High

688820

YM11A
Transposon Ty1-ML1 Gag polyprotein

1

7

High-throughput

0.457

High

688827

YL257
Uncharacterized protein YLR257W

1

1

High-throughput

0.457

High

688830

CORO
Coronin-like protein

1

3

High-throughput

0.457

High

688831

TPO3
Polyamine transporter 3

1

6

High-throughput

0.457

High

688837

HSP33
Probable glutathione-independent glyoxalase HSP33

1

1

High-throughput

0.457

High

688847

YN11A
Transposon Ty1-NL1 Gag polyprotein

1

7

High-throughput

0.457

High

688848

YD21A
Transposon Ty2-DR1 Gag polyprotein

1

11

High-throughput

0.457

High

688849

ISA2
Iron-sulfur assembly protein 2

1

1

High-throughput

0.457

High

688850

LAS17
Proline-rich protein LAS17

1

3

High-throughput

0.457

High

688852

YN12A
Transposon Ty1-NL2 Gag polyprotein

1

8

High-throughput

0.457

High

688853

YP14A
Transposon Ty1-PR3 Gag polyprotein

1

8

High-throughput

0.457

High

688854

YO11A
Transposon Ty1-OL Gag polyprotein

1

8

High-throughput

0.457

High

688800

UBC7
Ubiquitin-conjugating enzyme E2 7

1

8

High-throughput

0.457

High

449955

HSP73
Heat shock protein SSA3

1

13

High-throughput

0.445

High

612212

HSP12
12 kDa heat shock protein

1

1

High-throughput

0.445

High

688731

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.445

High

688732

HSP79
Heat shock protein homolog SSE2

1

19

High-throughput

0.445

High

688756

SSZ1
Ribosome-associated complex subunit SSZ1

1

11

High-throughput

0.445

High

688794

PFD4
Prefoldin subunit 4

1

2

High-throughput

0.445

High

688818

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.445

High

688832

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

9

High-throughput

0.445

High

402907

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

High-throughput

0.437

High

688734

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

1

High-throughput

0.437

High

688758

YH02
Uncharacterized protein YHR202W

1

1

High-throughput

0.437

High

688775

AIM21
Altered inheritance of mitochondria protein 21

1

4

High-throughput

0.437

High

688810

CEF1
Pre-mRNA-splicing factor CEF1

1

8

High-throughput

0.437

High

688823

ENT2
Epsin-2

1

1

High-throughput

0.437

High

688783

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

688816

KRE28
Spindle pole body component KRE28

1

0

High-throughput

0.265

Low

434700

CHS1
Chitin synthase 1

1

0

High-throughput

0.261

Low

688750

YB8A
Putative uncharacterized protein YBR285W

1

0

High-throughput

0.261

Low

688757

BZZ1
Protein BZZ1

1

0

High-throughput

0.261

Low

688767

SIP5
Protein SIP5

1

0

High-throughput

0.261

Low

688782

IRC8
Uncharacterized protein IRC8

1

0

High-throughput

0.261

Low

688784

YD186
Uncharacterized protein YDL186W

1

0

High-throughput

0.261

Low

688797

AIM11
Altered inheritance of mitochondria protein 11

1

0

High-throughput

0.261

Low

688806

ADD37
Alpha1-proteinase inhibitor-degradation deficient protein 37

1

0

High-throughput

0.261

Low

688811

YMD7
Uncharacterized protein YML037C

1

0

High-throughput

0.261

Low

688834

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.261

Low

688838

SRO7
Lethal(2) giant larvae protein homolog SRO7

1

0

High-throughput

0.261

Low

688743

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

688749

YB9F
Uncharacterized protein YBR259W

1

0

High-throughput

0.249

Low

688753

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.249

Low

688755

OCA5
Oxidant-induced cell-cycle arrest protein 5

1

0

High-throughput

0.249

Low

688763

MRX1
MIOREX complex component 1

1

0

High-throughput

0.249

Low

688773

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.249

Low

688804

MUK1
Protein MUK1

1

0

High-throughput

0.249

Low

688805

ATP25
ATPase synthesis protein 25, mitochondrial

1

0

High-throughput

0.249

Low

688815

SEG1
Eisosome protein SEG1

1

0

High-throughput

0.249

Low

688819

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024