Protein: FCF1
rRNA-processing protein FCF1 (FAF1-copurifying factor 1)

Gene: FCF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 83
UniProt ID: Q05498

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0004521 - RNA endonuclease activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

798307

ENP1
Essential nuclear protein 1

4

1

Small-scale

0.676

High

1051178

UTP23
rRNA-processing protein UTP23

1

2

Small-scale

0.647

High

1046029

DHR1
Probable ATP-dependent RNA helicase DHR1

3

2

High-throughput

0.640

High

747047

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

1

High-throughput

0.618

High

918820

UTP22
U3 small nucleolar RNA-associated protein 22

2

1

High-throughput

0.614

High

865169

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

1

Small-scale

0.601

High

826210

FAF1
Protein FAF1

2

0

Small-scale

0.585

High

677562

KRR1
KRR1 small subunit processome component

2

2

High-throughput

0.584

High

678458

PWP2
Periodic tryptophan protein 2

2

1

Small-scale

0.584

High

844611

UTP10
U3 small nucleolar RNA-associated protein 10

2

1

High-throughput

0.584

High

1046787

UTP14
U3 small nucleolar RNA-associated protein 14

2

2

High-throughput

0.584

High

1051165

NOC4
Nucleolar complex protein 4

2

2

High-throughput

0.584

High

1051181

NOP58
Nucleolar protein 58

2

3

High-throughput

0.584

High

782448

RPF2
Ribosome biogenesis protein RPF2

2

0

High-throughput

0.576

High

923983

CSL4
Exosome complex component CSL4

2

0

High-throughput

0.559

High

851017

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.518

High

632740

DBP4
ATP-dependent RNA helicase HCA4

1

5

High-throughput

0.479

High

672946

RRP43
Exosome complex component RRP43

1

1

High-throughput

0.479

High

673226

RRP7
Ribosomal RNA-processing protein 7

1

2

High-throughput

0.479

High

682383

SPB4
ATP-dependent rRNA helicase SPB4

1

5

High-throughput

0.479

High

782103

RL1D1
Ribosome biogenesis protein UTP30

1

1

High-throughput

0.479

High

808306

RRP8
25S rRNA

1

1

High-throughput

0.479

High

852600

ROK1
ATP-dependent RNA helicase ROK1

1

3

High-throughput

0.479

High

863135

RRP41
Exosome complex component SKI6

1

2

High-throughput

0.479

High

864517

MTR4
ATP-dependent RNA helicase DOB1

1

2

High-throughput

0.479

High

918891

RRP46
Exosome complex component RRP46

1

2

High-throughput

0.479

High

925194

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.479

High

1039849

UTP17
NET1-associated nuclear protein 1

1

3

High-throughput

0.479

High

1042231

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

1045103

UTP5
U3 small nucleolar RNA-associated protein 5

1

2

High-throughput

0.479

High

1050159

RRP5
rRNA biogenesis protein RRP5

1

1

High-throughput

0.479

High

1051158

RRP45
Exosome complex component RRP45

1

2

High-throughput

0.479

High

1051159

UTP13
U3 small nucleolar RNA-associated protein 13

1

3

High-throughput

0.479

High

1051160

UTP21
U3 small nucleolar RNA-associated protein 21

1

2

High-throughput

0.479

High

1051164

RRP9
Ribosomal RNA-processing protein 9

1

1

High-throughput

0.479

High

1051167

UTP4
U3 small nucleolar RNA-associated protein 4

1

2

High-throughput

0.479

High

1051169

RRP44
Exosome complex exonuclease DIS3

1

2

High-throughput

0.479

High

1051173

FCF2
rRNA-processing protein FCF2

1

1

High-throughput

0.479

High

1051176

UTP12
U3 small nucleolar RNA-associated protein 12

1

2

High-throughput

0.479

High

1051177

RRP42
Exosome complex component RRP42

1

2

High-throughput

0.479

High

1051179

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

1051184

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

754331

DCA13
Protein SOF1

1

0

High-throughput

0.458

High

758406

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

763625

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

804748

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.458

High

804957

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

806570

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.458

High

817629

UTP7
U3 small nucleolar RNA-associated protein 7

1

0

High-throughput

0.458

High

818340

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

823383

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

825080

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

825559

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

871053

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

871123

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

919168

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

923252

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.458

High

924629

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

1036407

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.458

High

1046248

UTP15
U3 small nucleolar RNA-associated protein 15

1

0

High-throughput

0.458

High

1051161

SGD1
Suppressor of glycerol defect protein 1

1

0

High-throughput

0.458

High

1051162

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

1051163

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.458

High

1051166

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

1051168

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

1051170

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

1051171

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

1051172

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.458

High

1051174

SAS10
Something about silencing protein 10

1

0

High-throughput

0.458

High

1051175

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

1051180

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

1051182

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

1051185

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

676348

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.457

High

503243

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

826403

MPH1
ATP-dependent DNA helicase MPH1

1

1

High-throughput

0.437

High

1051183

RS22B
Small ribosomal subunit protein uS8B

1

2

High-throughput

0.437

High

453205

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.279

Low

807745

ATC2
Calcium-transporting ATPase 2

1

0

High-throughput

0.279

Low

531403

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.261

Low

590724

HSP26
Heat shock protein 26

1

0

High-throughput

0.261

Low

922953

MPP6
M-phase phosphoprotein 6 homolog

1

0

High-throughput

0.249

Low

510820

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025