Protein: SOS1
Son of sevenless homolog 1 (SOS-1)

Gene: SOS1
Organism: Homo sapiens
Interactions: 80
UniProt ID: Q07889

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0001942 - hair follicle development
GO:0002931 - response to ischemia
GO:0003209 - cardiac atrium morphogenesis
GO:0003344 - pericardium morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

924511

GRB2
Growth factor receptor-bound protein 2

63

20

Small-scale

0.997

High

338323

EGFR
Epidermal growth factor receptor

15

20

Small-scale

0.980

High

349267

RASH
GTPase HRas

10

20

Small-scale

0.972

High

992477

ITSN1
Intersectin-1

8

19

Small-scale

0.971

High

802575

CRK
Adapter molecule crk

9

20

Small-scale

0.970

High

557668

NCK1
SH2/SH3 adapter protein NCK1

7

20

Small-scale

0.969

High

580987

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

4

7

Small-scale

0.906

High

992487

FRS2
Fibroblast growth factor receptor substrate 2

5

2

Small-scale

0.906

High

802826

CRKL
Crk-like protein

4

20

High-throughput

0.881

High

992474

EPS8
Epidermal growth factor receptor kinase substrate 8

4

20

Small-scale

0.873

High

131240

BIN1
Myc box-dependent-interacting protein 1

3

9

Small-scale

0.827

High

992496

ITSN2
Intersectin-2

2

16

High-throughput

0.791

High

883330

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

17

High-throughput

0.783

High

412150

FYN
Tyrosine-protein kinase Fyn

2

20

Small-scale

0.768

High

442816

HCK
Tyrosine-protein kinase HCK

2

20

Small-scale

0.768

High

666085

SHC1
SHC-transforming protein 1

13

20

Small-scale

0.756

High

506575

BCR
Breakpoint cluster region protein

2

14

Small-scale

0.754

High

992505

CD2AP
CD2-associated protein

2

20

Small-scale

0.754

High

992479

SPD2A
SH3 and PX domain-containing protein 2A

1

19

Small-scale

0.747

High

992483

ABI1
Abl interactor 1

1

14

Small-scale

0.747

High

596214

NEBU
Nebulin

1

18

Small-scale

0.716

High

992476

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

11

High-throughput

0.698

High

647556

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.692

High

985942

PTN11
Tyrosine-protein phosphatase non-receptor type 11

4

6

Small-scale

0.683

High

992502

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

9

Small-scale

0.665

High

992506

SNX9
Sorting nexin-9

1

3

Small-scale

0.665

High

992481

NOSTN
Nostrin

1

14

Small-scale

0.647

High

992501

TNIK
TRAF2 and NCK-interacting protein kinase

1

7

High-throughput

0.621

High

209038

NCK2
Cytoplasmic protein NCK2

1

20

Small-scale

0.618

High

337446

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.618

High

348635

RASN
GTPase NRas

1

20

Small-scale

0.618

High

350111

RASK
GTPase KRas

1

20

Small-scale

0.618

High

384711

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.618

High

426995

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

4

Small-scale

0.618

High

441491

MET
Hepatocyte growth factor receptor

1

14

Small-scale

0.618

High

522934

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.618

High

925226

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.618

High

992475

GRAP
GRB2-related adapter protein

1

20

Small-scale

0.618

High

992478

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

3

High-throughput

0.618

High

992480

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

992486

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

20

Small-scale

0.618

High

992489

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.618

High

992490

SNX18
Sorting nexin-18

1

3

Small-scale

0.618

High

992491

RIT2
GTP-binding protein Rit2

1

20

Small-scale

0.618

High

992492

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.618

High

992495

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

20

Small-scale

0.618

High

992493

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

12

High-throughput

0.590

High

992503

CSN3
COP9 signalosome complex subunit 3

1

1

Small-scale

0.586

High

554300

MUC1
Mucin-1

2

2

Small-scale

0.584

High

434180

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

18

Small-scale

0.575

High

983594

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.575

High

992485

DP13B
DCC-interacting protein 13-beta

1

1

Small-scale

0.575

High

225239

3BP5
SH3 domain-binding protein 5

2

0

High-throughput

0.565

High

941685

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

3

Small-scale

0.561

High

959369

VIGLN
Vigilin

1

2

High-throughput

0.541

High

856369

EFNA4
Ephrin-A4

1

1

High-throughput

0.536

High

411690

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.527

High

992484

TXND5
Thioredoxin domain-containing protein 5

2

4

High-throughput

0.521

High

171131

CETN3
Centrin-3

1

1

High-throughput

0.515

High

813406

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

992499

GGA1
ADP-ribosylation factor-binding protein GGA1

1

1

High-throughput

0.501

High

427534

ANXA2
Annexin A2

1

0

Small-scale

0.480

High

130862

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.479

High

208131

SPY2
Protein sprouty homolog 2

1

5

Small-scale

0.479

High

208418

SPY3
Protein sprouty homolog 3

1

5

Small-scale

0.479

High

584388

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.479

High

607645

NDKB
Nucleoside diphosphate kinase B

1

4

High-throughput

0.479

High

610371

CBL
E3 ubiquitin-protein ligase CBL

1

6

Small-scale

0.479

High

655332

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

7

High-throughput

0.479

High

665875

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

7

Small-scale

0.479

High

719460

MERL
Merlin

1

5

Small-scale

0.479

High

856315

EFNA3
Ephrin-A3

1

1

High-throughput

0.479

High

992482

SRRM1
Serine/arginine repetitive matrix protein 1

1

4

High-throughput

0.479

High

992488

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

992497

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

9

High-throughput

0.479

High

992498

CSN7A
COP9 signalosome complex subunit 7a

1

2

Small-scale

0.479

High

559079

H15
Histone H1.5

1

1

High-throughput

0.470

High

992504

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

992494

BRD8
Bromodomain-containing protein 8

1

3

High-throughput

0.437

High

992500

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024