Protein: NSMA3
Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III)

Gene: NSMA3, SMPD4
Organism: Homo sapiens
Interactions: 175
UniProt ID: Q9NXE4

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004767 - sphingomyelin phosphodiesterase activity
GO:0005635 - nuclear envelope
GO:0005640 - nuclear outer membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

386298

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

2

High-throughput

0.640

High

1430984

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.576

High

951471

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

890408

NU153
Nuclear pore complex protein Nup153

1

1

High-throughput

0.536

High

1451975

ALK
ALK tyrosine kinase receptor

2

2

High-throughput

0.533

High

411081

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

High-throughput

0.526

High

945318

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.513

High

1126375

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1134407

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

1159246

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

1349189

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

1382219

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1399634

OPALI
Opalin

1

0

High-throughput

0.513

High

133136

FOXE1
Forkhead box protein E1

1

6

High-throughput

0.489

High

288141

FOXH1
Forkhead box protein H1

1

7

High-throughput

0.489

High

938032

FOXA3
Hepatocyte nuclear factor 3-gamma

1

7

High-throughput

0.489

High

945729

FOXL2
Forkhead box protein L2

1

6

High-throughput

0.489

High

1091257

FOXI1
Forkhead box protein I1

1

7

High-throughput

0.489

High

1091359

FOXL1
Forkhead box protein L1

1

7

High-throughput

0.489

High

1235342

STYK1
Tyrosine-protein kinase STYK1

1

1

High-throughput

0.489

High

1253580

FOXI2
Forkhead box protein I2

1

6

High-throughput

0.489

High

1407765

FOXB1
Forkhead box protein B1

1

7

High-throughput

0.489

High

48821

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

126832

RHOD
Rho-related GTP-binding protein RhoD

1

5

High-throughput

0.479

High

179643

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

2

High-throughput

0.479

High

376016

RASK
GTPase KRas

1

2

High-throughput

0.479

High

466490

RHOC
Rho-related GTP-binding protein RhoC

1

4

High-throughput

0.479

High

540710

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.479

High

581329

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.479

High

604236

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

630649

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.479

High

634667

LMNB1
Lamin-B1

1

2

High-throughput

0.479

High

902109

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

953704

RAC3
Ras-related C3 botulinum toxin substrate 3

1

4

High-throughput

0.479

High

955670

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.479

High

962555

RHOA
Transforming protein RhoA

1

5

High-throughput

0.479

High

1087314

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1152268

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.479

High

1251352

DJC14
DnaJ homolog subfamily C member 14

1

1

High-throughput

0.479

High

1360949

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.479

High

1381538

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

1395967

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.479

High

1401716

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

1412696

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1431267

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

1451972

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

124520

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

140009

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.458

High

174126

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

226228

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

243117

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

291566

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

327476

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

337976

CNEP1
CTD nuclear envelope phosphatase 1

1

0

High-throughput

0.458

High

417802

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418472

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

488877

FURIN
Furin

1

0

High-throughput

0.458

High

548377

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

611385

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

699192

CALX
Calnexin

1

0

High-throughput

0.458

High

715811

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

837872

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

847718

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

880718

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

895110

EMD
Emerin

1

0

High-throughput

0.458

High

904158

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

941981

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

975279

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

976608

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

1027210

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

1058691

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1111729

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1125698

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1229108

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1252256

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1276338

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1309904

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1312616

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1334034

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1337696

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1339205

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1383117

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1401244

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1404243

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1414478

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1421160

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1431769

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1436339

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1450110

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1451727

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1451778

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

1451967

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1451970

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1451978

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.458

High

1451980

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

189012

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

189878

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

285497

EED
Polycomb protein EED

1

1

High-throughput

0.437

High

412703

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

630995

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.437

High

631515

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.437

High

777780

VGFR3
Vascular endothelial growth factor receptor 3

1

1

High-throughput

0.437

High

901075

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.437

High

910225

RND2
Rho-related GTP-binding protein RhoN

1

6

High-throughput

0.437

High

937659

FOXG1
Forkhead box protein G1

1

7

High-throughput

0.437

High

1145134

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.437

High

1151904

RHOH
Rho-related GTP-binding protein RhoH

1

5

High-throughput

0.437

High

1286935

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1312286

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.437

High

1323016

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1448837

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

1451971

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1451973

ANC2
Anaphase-promoting complex subunit 2

1

1

High-throughput

0.437

High

1451974

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

1451977

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.437

High

380169

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

880883

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.426

High

1209726

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1242959

S39A4
Zinc transporter ZIP4

1

0

High-throughput

0.426

High

1337983

ZNT7
Zinc transporter 7

1

0

High-throughput

0.426

High

1403637

SL9A7
Sodium/hydrogen exchanger 7

1

0

High-throughput

0.426

High

1451536

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

1451979

S27A5
Long-chain fatty acid transport protein 5

1

0

High-throughput

0.426

High

182808

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

848578

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.279

Low

1113001

CUL2
Cullin-2

1

0

High-throughput

0.279

Low

1150262

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.279

Low

1325936

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1363241

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1451981

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1337424

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.269

Low

1437818

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.269

Low

1446198

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.265

Low

294425

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

302984

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.249

Low

538010

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

570615

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.249

Low

580711

AMPN
Aminopeptidase N

1

0

High-throughput

0.249

Low

696681

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

710767

EPHA8
Ephrin type-A receptor 8

1

0

High-throughput

0.249

Low

769342

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

831531

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

879536

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

905205

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

986768

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.249

Low

1004217

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.249

Low

1005167

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1163431

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1214588

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.249

Low

1226292

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.249

Low

1227572

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1238838

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

1255817

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1276871

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1288506

LBN
Limbin

1

0

High-throughput

0.249

Low

1293177

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1293680

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1367423

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1382961

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1397490

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1403811

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1405883

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.249

Low

1434055

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1448025

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.249

Low

1448156

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1451968

WSB2
WD repeat and SOCS box-containing protein 2

1

0

High-throughput

0.249

Low

1451969

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

425650

ISG15
Ubiquitin-like protein ISG15

1

0

Small-scale

0.232

Low

1157203

S15A2
Solute carrier family 15 member 2

1

0

High-throughput

0.232

Low

1249750

S49A3
Solute carrier family 49 member A3

1

0

High-throughput

0.232

Low

1271278

SV2B
Synaptic vesicle glycoprotein 2B

1

0

High-throughput

0.232

Low

1309982

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

0

High-throughput

0.232

Low

1359510

CTL1
Choline transporter-like protein 1

1

0

High-throughput

0.232

Low

1428945

SC5A7
High affinity choline transporter 1

1

0

High-throughput

0.232

Low

1451976

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025