Protein: FDFT
Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase 1)

Gene: FDFT, FDFT1
Organism: Homo sapiens
Interactions: 136
UniProt ID: P37268

Gene Ontology (top 5):
GO:0004310 - farnesyl-diphosphate farnesyltransferase activity
GO:0004311 - farnesyltranstransferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006694 - steroid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740964

UN93B
Protein unc-93 homolog B1

3

0

High-throughput

0.646

High

740931

ST32C
Serine/threonine-protein kinase 32C

3

0

High-throughput

0.638

High

740897

AGRE5
Adhesion G protein-coupled receptor E5

2

1

High-throughput

0.628

High

740930

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

2

High-throughput

0.611

High

740959

P2RX4
P2X purinoceptor 4

2

1

High-throughput

0.611

High

740963

ELOV4
Very long chain fatty acid elongase 4

2

1

High-throughput

0.606

High

740980

POMT2
Protein O-mannosyl-transferase 2

2

0

High-throughput

0.602

High

740985

SRPRB
Signal recognition particle receptor subunit beta

2

0

High-throughput

0.585

High

267226

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

2

0

High-throughput

0.580

High

380252

HG2A
HLA class II histocompatibility antigen gamma chain

2

0

High-throughput

0.580

High

740925

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.580

High

740937

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

740954

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.580

High

740956

PANX1
Pannexin-1

2

0

High-throughput

0.580

High

740983

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

740900

P2RX1
P2X purinoceptor 1

2

1

High-throughput

0.574

High

740904

RHOA
Transforming protein RhoA

2

1

High-throughput

0.571

High

740906

RAC1
Ras-related C3 botulinum toxin substrate 1

2

1

High-throughput

0.571

High

740903

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

740910

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

740942

GP152
Probable G-protein coupled receptor 152

2

4

High-throughput

0.553

High

740893

GLP1R
Glucagon-like peptide 1 receptor

1

2

Small-scale

0.552

High

216682

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.549

High

740914

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

1

High-throughput

0.541

High

740981

RUVB2
RuvB-like 2

1

1

High-throughput

0.541

High

171948

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

714637

CNR2
Cannabinoid receptor 2

1

2

Small-scale

0.536

High

740950

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.536

High

444851

ANXA5
Annexin A5

1

0

High-throughput

0.518

High

574505

ITB5
Integrin beta-5

1

0

High-throughput

0.518

High

740915

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.518

High

740960

TMM43
Transmembrane protein 43

1

0

High-throughput

0.518

High

740982

RUVB1
RuvB-like 1

1

1

High-throughput

0.515

High

349165

RASH
GTPase HRas

1

0

High-throughput

0.513

High

570829

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

0

High-throughput

0.513

High

740894

GRK6
G protein-coupled receptor kinase 6

1

0

High-throughput

0.513

High

740935

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

740941

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.513

High

740944

TS1R2
Taste receptor type 1 member 2

1

0

High-throughput

0.513

High

740952

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

740962

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

740966

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

207774

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

High-throughput

0.493

High

740901

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.493

High

740948

NU205
Nuclear pore complex protein Nup205

1

0

High-throughput

0.493

High

156801

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.489

High

600744

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

1

High-throughput

0.489

High

686270

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

2

High-throughput

0.489

High

723276

APJ
Apelin receptor

1

1

High-throughput

0.489

High

740909

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

740969

LPAR2
Lysophosphatidic acid receptor 2

1

2

High-throughput

0.489

High

740986

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

377150

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

740911

CUL3
Cullin-3

1

1

High-throughput

0.479

High

740932

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

740938

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

740965

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.479

High

155293

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

163763

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

226709

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

243319

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.458

High

319743

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

338049

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

390095

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

390745

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

503573

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

509531

UBL4A
Ubiquitin-like protein 4A

1

0

High-throughput

0.458

High

518598

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.458

High

650532

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

668476

PML
Protein PML

1

0

High-throughput

0.458

High

740895

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

740899

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

740916

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

740927

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

740933

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.458

High

740936

PNKD
Probable hydrolase PNKD

1

0

High-throughput

0.458

High

740943

RBCC1
RB1-inducible coiled-coil protein 1

1

0

High-throughput

0.458

High

740958

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

740961

DERL1
Derlin-1

1

0

High-throughput

0.458

High

740968

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

740971

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

740978

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

740979

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

740912

CUL4A
Cullin-4A

1

1

High-throughput

0.437

High

740947

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

Small-scale

0.437

High

740949

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

740984

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

High-throughput

0.437

High

740902

CD81
CD81 antigen

1

0

High-throughput

0.426

High

740926

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.407

High

740939

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

2

0

High-throughput

0.328

High

740973

CNNM1
Metal transporter CNNM1

2

0

High-throughput

0.328

High

515997

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

740896

CXA8
Gap junction alpha-8 protein

2

0

High-throughput

0.316

High

740913

NTCP
Hepatic sodium/bile acid cotransporter

2

0

High-throughput

0.316

High

740921

AR13B
ADP-ribosylation factor-like protein 13B

2

0

High-throughput

0.316

High

740922

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

740970

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.316

High

264182

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.279

Low

319521

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

362892

FINC
Fibronectin

1

0

High-throughput

0.279

Low

439104

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

656355

DMB
HLA class II histocompatibility antigen, DM beta chain

1

0

High-throughput

0.279

Low

740908

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.279

Low

740917

PDK3
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low

740920

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.279

Low

740929

BOP
Protein Bop

1

0

High-throughput

0.279

Low

740951

HDA10
Polyamine deacetylase HDAC10

1

0

High-throughput

0.279

Low

740955

OPALI
Opalin

1

0

High-throughput

0.279

Low

278915

SPF30
Survival of motor neuron-related-splicing factor 30

1

0

High-throughput

0.269

Low

740945

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

0

High-throughput

0.269

Low

359718

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.251

Low

205120

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

302978

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

552101

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

669249

KAIN
Kallistatin

1

0

High-throughput

0.249

Low

719840

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

740892

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

740898

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

740905

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

740907

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

740919

DUS6
Dual specificity protein phosphatase 6

1

0

High-throughput

0.249

Low

740923

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

740924

FYB2
FYN-binding protein 2

1

0

High-throughput

0.249

Low

740928

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

740934

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

740940

DNJB8
DnaJ homolog subfamily B member 8

1

0

High-throughput

0.249

Low

740946

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low

740953

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

740957

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

740967

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

740972

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

740974

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

740975

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

740976

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.249

Low

740977

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

740918

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024