Protein: PYC
Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)

Gene: PYC, PC
Organism: Homo sapiens
Interactions: 163
UniProt ID: P11498

Gene Ontology (top 5):
GO:0004736 - pyruvate carboxylase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

513525

PYC
Pyruvate carboxylase, mitochondrial

2

16

Small-scale

0.812

High

513624

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

1

High-throughput

0.667

High

513532

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

2

2

High-throughput

0.628

High

513650

STRAP
Serine-threonine kinase receptor-associated protein

2

13

High-throughput

0.628

High

398219

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

15

High-throughput

0.618

High

398320

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

18

High-throughput

0.618

High

513571

ACACA
Acetyl-CoA carboxylase 1

1

17

High-throughput

0.618

High

513621

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

16

High-throughput

0.618

High

513632

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

18

High-throughput

0.618

High

513631

ANTR1
Anthrax toxin receptor 1

2

1

High-throughput

0.611

High

326297

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

343940

ASSY
Argininosuccinate synthase

2

0

High-throughput

0.602

High

226370

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.584

High

385989

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

513542

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

513546

MAOX
NADP-dependent malic enzyme

1

2

Small-scale

0.565

High

513527

TSHR
Thyrotropin receptor

2

2

High-throughput

0.558

High

207006

XRCC3
DNA repair protein XRCC3

1

3

High-throughput

0.536

High

383563

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

5

High-throughput

0.536

High

456252

IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

1

4

High-throughput

0.536

High

513533

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

513552

RAB7A
Ras-related protein Rab-7a

1

2

High-throughput

0.536

High

513554

YBEY
Endoribonuclease YbeY

1

2

High-throughput

0.536

High

513565

SHC2
SHC-transforming protein 2

1

6

High-throughput

0.536

High

513581

EPHA7
Ephrin type-A receptor 7

1

1

High-throughput

0.536

High

513589

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

1

High-throughput

0.536

High

513602

PAF1
RNA polymerase II-associated factor 1 homolog

1

4

High-throughput

0.536

High

513619

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

2

High-throughput

0.536

High

513625

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

High-throughput

0.536

High

513648

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

271910

FCN3
Ficolin-3

1

0

High-throughput

0.513

High

513544

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

0

High-throughput

0.513

High

513561

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.513

High

513569

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

513570

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

0

High-throughput

0.513

High

513585

LYRM7
Complex III assembly factor LYRM7

1

0

High-throughput

0.513

High

513606

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

513636

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

513643

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

513528

AATC
Aspartate aminotransferase, cytoplasmic

1

1

Small-scale

0.501

High

513541

MDHM
Malate dehydrogenase, mitochondrial

1

1

Small-scale

0.501

High

513613

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

High-throughput

0.501

High

513575

SLAF1
Signaling lymphocytic activation molecule

1

2

High-throughput

0.489

High

513596

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.489

High

513618

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

513629

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

1

High-throughput

0.489

High

513540

MDHC
Malate dehydrogenase, cytoplasmic

1

2

Small-scale

0.484

High

513566

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.484

High

119121

LEG9
Galectin-9

1

6

High-throughput

0.479

High

125119

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

10

Small-scale

0.479

High

150835

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

2

High-throughput

0.479

High

294305

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

296860

LTN1
E3 ubiquitin-protein ligase listerin

1

3

High-throughput

0.479

High

304008

UBR5
E3 ubiquitin-protein ligase UBR5

1

10

Small-scale

0.479

High

337843

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

345794

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

373601

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

384172

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

388186

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

417889

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

475285

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

Small-scale

0.479

High

503328

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

513529

ARF4
ADP-ribosylation factor 4

1

11

High-throughput

0.479

High

513534

1433T
14-3-3 protein theta

1

5

High-throughput

0.479

High

513535

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

513536

PML
Protein PML

1

8

High-throughput

0.479

High

513537

HSP74
Heat shock 70 kDa protein 4

1

12

Small-scale

0.479

High

513539

TRI23
E3 ubiquitin-protein ligase TRIM23

1

16

High-throughput

0.479

High

513543

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

513545

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

513548

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

513549

ARL4D
ADP-ribosylation factor-like protein 4D

1

18

High-throughput

0.479

High

513551

CDK7
Cyclin-dependent kinase 7

1

7

High-throughput

0.479

High

513553

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

513555

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.479

High

513557

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

Small-scale

0.479

High

513560

RBX1
E3 ubiquitin-protein ligase RBX1

1

6

High-throughput

0.479

High

513562

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.479

High

513563

SSBP2
Single-stranded DNA-binding protein 2

1

2

Small-scale

0.479

High

513567

VIGLN
Vigilin

1

2

High-throughput

0.479

High

513573

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

High-throughput

0.479

High

513576

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

513577

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.479

High

513578

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

513579

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

513582

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

513583

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

513584

DCAF6
DDB1- and CUL4-associated factor 6

1

16

High-throughput

0.479

High

513587

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.479

High

513588

ZN746
Zinc finger protein 746

1

4

High-throughput

0.479

High

513590

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

513591

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

513594

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

513595

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

513597

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.479

High

513599

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

513600

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

513601

WDTC1
WD and tetratricopeptide repeats protein 1

1

18

High-throughput

0.479

High

513604

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.479

High

513610

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

513612

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

513614

FBXW7
F-box/WD repeat-containing protein 7

1

13

High-throughput

0.479

High

513615

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

513616

FBXW5
F-box/WD repeat-containing protein 5

1

2

High-throughput

0.479

High

513617

PF21A
PHD finger protein 21A

1

6

High-throughput

0.479

High

513622

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

513623

NECD
Necdin

1

3

High-throughput

0.479

High

513628

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

513630

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

513633

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.479

High

513634

ANLN
Anillin

1

2

High-throughput

0.479

High

513639

HECW2
E3 ubiquitin-protein ligase HECW2

1

10

High-throughput

0.479

High

513641

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

513642

TES
Testin

1

1

High-throughput

0.479

High

513644

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.479

High

513645

RCOR1
REST corepressor 1

1

4

High-throughput

0.479

High

513647

FBW1A
F-box/WD repeat-containing protein 1A

1

16

High-throughput

0.479

High

513652

SAR1B
Small COPII coat GTPase SAR1B

1

20

High-throughput

0.479

High

513580

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

513605

DTWD2
tRNA-uridine aminocarboxypropyltransferase 2

1

0

High-throughput

0.458

High

513608

CEMIP
Cell migration-inducing and hyaluronan-binding protein

1

0

Small-scale

0.458

High

513649

KLK5
Kallikrein-5

1

0

High-throughput

0.458

High

496175

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

513530

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

High-throughput

0.445

High

513572

IFT88
Intraflagellar transport protein 88 homolog

1

3

High-throughput

0.445

High

513586

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.445

High

513646

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

513653

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

15

High-throughput

0.445

High

225493

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

231980

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.437

High

329289

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

353373

PIGR
Polymeric immunoglobulin receptor

1

4

Small-scale

0.437

High

509849

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

1

High-throughput

0.437

High

513526

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

513538

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

513547

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

513550

TSP3
Thrombospondin-3

1

1

High-throughput

0.437

High

513558

ARF3
ADP-ribosylation factor 3

1

11

High-throughput

0.437

High

513559

H4
Histone H4

1

5

High-throughput

0.437

High

513564

ARF5
ADP-ribosylation factor 5

1

11

High-throughput

0.437

High

513574

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.437

High

513592

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

8

Small-scale

0.437

High

513593

DET1
DET1 homolog

1

4

High-throughput

0.437

High

513603

ARL10
ADP-ribosylation factor-like protein 10

1

18

High-throughput

0.437

High

513609

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

513626

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

513635

SAR1A
Small COPII coat GTPase SAR1A

1

20

High-throughput

0.437

High

513637

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

513651

ARL5A
ADP-ribosylation factor-like protein 5A

1

20

High-throughput

0.437

High

513640

UXT
Protein UXT

1

0

Small-scale

0.426

High

513627

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

513568

DEF5
Defensin alpha 5

2

0

High-throughput

0.328

High

513620

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

70500

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

0

High-throughput

0.279

Low

513531

TRYB2
Tryptase beta-2

1

0

High-throughput

0.279

Low

513556

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.279

Low

513598

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

513607

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

513638

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

129667

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low

428895

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

513611

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024